2018
DOI: 10.1002/jccs.201800140
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Sequential one‐pot multicomponent synthesis of bis‐aminothiazols and evaluation of their antibacterial and antioxidant activities

Abstract: A series of novel bis-thiazoles were synthesized through a one-pot semi-fivecomponent reaction of the prepared α-bisbromo ketones, aldehydes, and thiosemicarbazide in the presence of p-TsOH under reflux condition. Products were obtained in reasonable yields via an efficient, convenient, and simple setup. The inhibitory activity on bacterial growth of the products was studied against Gramnegative (Escherichia coli and Pseudomonas aeruginosa) and Gram-positive bacterial strains (Micrococcus luteus, Staphylococcu… Show more

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Cited by 6 publications
(9 citation statements)
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“…The remaining protons were observed at their expected aromatic region. The peak at δ 166.79 ppm in 13 Figure 2). The physical data of all synthesized compounds is given in (Table 1).…”
Section: Chemistrymentioning
confidence: 99%
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“…The remaining protons were observed at their expected aromatic region. The peak at δ 166.79 ppm in 13 Figure 2). The physical data of all synthesized compounds is given in (Table 1).…”
Section: Chemistrymentioning
confidence: 99%
“…The structures of synthesized (E)-N 0 -benzylidene-4-methyl-2-(2-propylpyridin-4-yl)thiazole-5-carbohydrazides (6a-l) were established on the basis of their 1 H and 13 C NMR spectral data and satisfactory high resolution mass spectrometry (HRMS) analysis. The 1 H NMR, 13 C NMR and HRMS spectrums (Figures S 1 -S 24 ) is given in supplementary file. The characteristic peak of amido N-H of compound 6c was observed at δ 12.23 ppm.…”
Section: Chemistrymentioning
confidence: 99%
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