Sequential one-pot synthesis and antioxidant evaluation of 5-amino-4-(arylselanyl)-1H-pyrazoles

Recent Advances in the Synthesis and Antioxidant Activity of Low Molecular Mass Organoselenium Molecules

“…The antioxidant activity of 47 was evaluated, with concentrations of 10-50 µM shown to inhibit sodium azide-induced formation of reactive species in the hippocampus and cortex of mice. 47 was also effective in scavenging DPPH at different concentrations (1-50 µM), and ABTS Jacob et al [79] have reported a sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles 49 catalyzed by CuI/bpy under mild conditions. The reaction of easily available benzoylacetonitriles 48, substituted hydrazines 44, and diaryl diselenides 4 in DMSO at 100 °C for 24 h, afforded a range of 5-amino-4-(arylselanyl)-1H-pyrazoles 49 in 49-90% yield (Scheme 21).…”

“…Whether these relative high drug concentrations can be achieved in vivo remains to be established. Jacob et al [79] have reported a sequential one-pot synthesis of 5-amino-4-(arylselanyl)-1H-pyrazoles 49 catalyzed by CuI/bpy under mild conditions. The reaction of easily available benzoylacetonitriles 48, substituted hydrazines 44, and diaryl diselenides 4 in DMSO at 100 °C for 24 h, afforded a range of 5-amino-4-(arylselanyl)-1H-pyrazoles 49 in 49-90% yield (Scheme 21).…”

Electrochemical Synthesis of Selenosulfonates from Diselenides and Sulfonyl Hydrazides

“…Sulfonyl and selenyl groups, serving as pivotal structural motifs, are prevalent within various biologically active compounds and pharmaceutical molecules . Selenosulfonates can be employed for the construction of sulfonyl or/and selenyl compounds, making them highly valuable synthetic blocks .…”