Sequential optimization of a pelletization process in a fluid bed rotor granulator

Korakianiti, E. S.; Rekkas, Dimitrios M.; Dallas, Paraskevas; Choulis, N.H.

doi:10.1016/s1773-2247(04)50102-8

Cited by 5 publications

(2 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The coating devices can be distinguished according to their method of introducing kinetic energy into a particle bed, between a purely mechanical input (e.g., mixer, disc and drum granulators) and a fluidization induced by the energy of the process gas flow (e.g., fluidized bed or spouted bed systems). Particularly in the pharmaceutical industry, fluidized bed rotor granulators (FBRG) are widely used to produce round coated pellets for oral drug delivery with a narrow size distribution, high strength, smooth surface and high sphericity [ 3 , 4 , 5 , 6 , 7 ]. This is achieved by the special design of a FBRG.…”

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of the Coating Liquid

2023

View full text Add to dashboard Cite

In the pharmaceutical industry, the coating of particles is a widely used technique to obtain desired surface modifications of the final product, e.g., controlled release of the active agents. The production of round, coated particles is particularly important, which is why fluidized bed rotor granulators (FBRG) are often used for this process. In this work, Computational Fluid Dynamics (CFD) coupled with the Discrete Element Method (DEM) is used to investigate the wet particle dynamics, depending on the properties of the coating liquid in a FBRG. The DEM contact model was extended by liquid bridge model to account for capillary and viscous forces during wet contact of particles. The influence of the relative contact velocity on the maximum length of the liquid bridge is also considered in the model. Five different cases were compared, in which the particles were initially wetted, and the liquid loading as well as the surface tension and viscosity of the liquid were changed. The results show that increasing viscosity leads to a denser particle bed and a significant decrease in particle rotational velocities and particle motion in the poloidal plane of the FBRG. Reducing the liquid loading and surface tension results in increased particle movement.

show abstract

Section: Introductionmentioning

confidence: 99%

Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of the Coating Liquid

2023

View full text Add to dashboard Cite

show abstract

“…The coating liquid is sprayed onto the pellets from a horizontal injection nozzle. Due to its specific fluid dynamics and mechanical conditions in the process chamber, pellets with high strength, smooth surface, and high sphericity could be obtained [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator

et al. 2020

View full text Add to dashboard Cite

Coating of particles is a widely used technique in order to obtain the desired surface modification of the final product, e.g., specific color or taste. Especially in the pharmaceutical industry, rotor granulators are used to produce round, coated pellets. In this work, the coating process in a rotor granulator is investigated numerically using computational fluid dynamics (CFD) coupled with the discrete element method (DEM). The droplets are generated as a second particulate phase in DEM. A liquid bridge model is implemented in the DEM model to take the capillary and viscous forces during the wet contact of the particles into account. A coating model is developed, where the drying of the liquid layer on the particles, as well as the particle growth, is considered. The simulation results of the dry process compared to the simulations with liquid injection show an important influence of the liquid on the particle dynamics. The formation of liquid bridges and the viscous forces in the liquid layer lead to an increase of the average particle velocity and contact time. Changing the injection rate of water has an influence on the contact duration but no significant effect on the particle dynamics. In contrast, the aqueous binder solution has an important influence on the particle movement.

show abstract

In-line particle size measurement and process influences on rotary fluidized bed agglomeration

et al. 2020

View full text Add to dashboard Cite

Sequential optimization of a pelletization process in a fluid bed rotor granulator

Cited by 5 publications

References 18 publications

Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of the Coating Liquid

Numerical Investigation of the Particle Dynamics in a Rotorgranulator Depending on the Properties of the Coating Liquid

CFD-DEM Simulation of a Coating Process in a Fluidized Bed Rotor Granulator

In-line particle size measurement and process influences on rotary fluidized bed agglomeration

Contact Info

Product

Resources

About