Sequential protocol biopsies from renal transplant recipients show an increasing expression of active TGF β

Jain, Sunjay; Mohamed, Mostafa; Sandford, Rebecca; Furness, Peter; Nicholson, Michael L.; Talbot, David

doi:10.1007/s00147-002-0472-3

Cited by 7 publications

(2 citation statements)

References 25 publications

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“…Therefore, angiogenesis may result from the local production of distinct factors, or via cytokine- and cell-mediated responses that increase local concentrations of VEGF. This interplay between cell-mediated immune reactions and the local delivery of TGF-β and VEGF by monocyte/macrophages have resulted in the development of paradigms to explain how angiogenesis and fibrosis are characteristic of chronic inflammatory disease states (Cotran, 1994; Brown et al, 1995; Freeman et al, 1995; Sharma et al, 1996; Inoue et al, 1998; Majno, 1998; Pilmore et al, 1999; Jain et al, 2000, 2002; Ezaki et al, 2001; Kanazawa et al, 2001; Mannon, 2006; Booth and Bishop, 2010). …”

Section: Leukocyte-induced Angiogenesis: a Pathological Response Thatmentioning

confidence: 99%

“…The process of EndMT occurs in association with pericyte loss, when EC are denuded from their basement membrane. Denuded EC and pericytes migrate into the surrounding tissue, where they are exposed to TGFβ that may be produced locally by multiple cell types and/or delivered into the graft by monocyte/macrophages (Jain et al, 2002; Booth and Bishop, 2010), thus leading to their differentiation into fibroblasts (illustrated in Figure 2). …”

Section: Endothelial Cell To Mesenchymal Transition: Possible Final Ementioning

confidence: 99%

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Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

Bruneau¹,

Woda²,

Daly³

et al. 2012

Front. Immun.

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In this review, we discuss how changes in the intragraft microenvironment serve to promote or sustain the development of chronic allograft rejection. We propose two key elements within the microenvironment that contribute to the rejection process. The first is endothelial cell proliferation and angiogenesis that serve to create abnormal microvascular blood flow patterns as well as local tissue hypoxia, and precedes endothelial-to-mesenchymal transition. The second is the overexpression of local cytokines and growth factors that serve to sustain inflammation and, in turn, function to promote a leukocyte-induced angiogenesis reaction. Central to both events is overexpression of vascular endothelial growth factor (VEGF), which is both pro-inflammatory and pro-angiogenic, and thus drives progression of the chronic rejection microenvironment. In our discussion, we focus on how inflammation results in angiogenesis and how leukocyte-induced angiogenesis is pathological. We also discuss how VEGF is a master control factor that fosters the development of the chronic rejection microenvironment. Overall, this review provides insight into the intragraft microenvironment as an important paradigm for future direction in the field.

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Section: Leukocyte-induced Angiogenesis: a Pathological Response Thatmentioning

confidence: 99%

Section: Endothelial Cell To Mesenchymal Transition: Possible Final Ementioning

confidence: 99%

Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

Bruneau¹,

Woda²,

Daly³

et al. 2012

Front. Immun.

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Correlative insights into the immunoexpression of transforming growth factor β-1 in acutely rejected renal allografts

Danilewicz

Wągrowska-Danilewicz

2006

Pathology - Research and Practice

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Plasma TGF‐β1 as a risk factor for gingival overgrowth

Ellis

Morgan

Kirby

et al. 2004

J Clinic Periodontology

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Furthermore, concomitant treatment with calcium channel blockers did not influence the levels of plasma TGF-beta1 in the patients group. The relationship between gingival overgrowth, independent periodontal variables and TGF-beta1 plasma concentrations was examined using univariate and multivariate regression analyses; low TGF-beta1 plasma concentrations were found to be a risk factor for gingival overgrowth in immunosuppressed patients concomitantly receiving a calcium channel blocker.

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Sequential protocol biopsies from renal transplant recipients show an increasing expression of active TGF β

Cited by 7 publications

References 25 publications

Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

Key Features of the Intragraft Microenvironment that Determine Long-Term Survival Following Transplantation

Correlative insights into the immunoexpression of transforming growth factor β-1 in acutely rejected renal allografts

Plasma TGF‐β1 as a risk factor for gingival overgrowth

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