Sequential Rosettes Drive C. elegans Ventral Nerve Cord Assembly

Soto, Martha C.

doi:10.1016/j.devcel.2017.04.007

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…Once the ventral cleft is enclosed, the neuroblasts rearrange by forming two temporally sequential rosettes in an anterior-posterior direction. The rosettes are resolved through a convergent-extension mechanism enabling the formation of a single neuroblast row along the ventral midline ( Figure 2D) [42,43]. Multiple studies have begun to uncover the interlinked relationship between the morphogenesis of neuronal and epidermal tissues.…”

Section: Epidermal-neuroblasts Axismentioning

confidence: 99%

Game of Tissues: How the Epidermis Thrones C. elegans Shape

Carvalho¹,

Broday²

2020

JDB

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The versatility of epithelial cell structure is universally exploited by organisms in multiple contexts. Epithelial cells can establish diverse polarized axes within their tridimensional structure which enables them to flexibly communicate with their neighbors in a 360° range. Hence, these cells are central to multicellularity, and participate in diverse biological processes such as organismal development, growth or immune response and their misfunction ultimately impacts disease. During the development of an organism, the first task epidermal cells must complete is the formation of a continuous sheet, which initiates its own morphogenic process. In this review, we will focus on the C. elegans embryonic epithelial morphogenesis. We will describe how its formation, maturation, and spatial arrangements set the final shape of the nematode C. elegans. Special importance will be given to the tissue-tissue interactions, regulatory tissue-tissue feedback mechanisms and the players orchestrating the process.

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Section: Epidermal-neuroblasts Axismentioning

confidence: 99%

Game of Tissues: How the Epidermis Thrones C. elegans Shape

Carvalho¹,

Broday²

2020

JDB

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“…During the elongation of C. elegans ventral nerve cord, SAX-3/Robo acts in parallel to VANG-1/Van Gogh (Shah et al, 2017a). A common feature is that these pathways regulate non-muscle myosin localization (Soto, 2017).…”

Section: Introductionmentioning

confidence: 99%

A compound PCP scheme underlies sequential rosettes-based cell intercalation

Cheng

Chen

et al. 2022

Preprint

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Sequential rosettes are a type of collective cell behavior recently discovered in the C. elegans embryo to mediate directional cell migration through sequential formation and resolution of multicellular rosettes involving the migrating cell and its neighboring cells along the way. Here we show that a Planar Cell Polarity (PCP)-related polarity scheme regulates sequential rosettes, which is distinct from the known mode of how PCP regulates multicellular rosettes in the process of convergent extension. Specifically, non-muscle myosin (NMY) localization and edge contraction are perpendicular to that of Van Gogh as opposed to colocalizing with Van Gogh. Further analyses suggest a two-component polarity scheme: one being the canonical PCP pathway with MIG-1/Frizzled and VANG-1/Van Gogh localized to the vertical edges, the other being MIG-1/Frizzled and NMY-2 localized to the midline/contracting edges. Both MIG-1/Frizzled and VANG-1/Van Gogh are required for NMY-2 localization and contraction of the midline edges, but in redundancy with LAT-1/Latrophilin, an adhesion GPCR which has not been shown to regulate multicellular rosettes. Our results establish a distinct mode of PCP-mediated cell intercalation and shed light on the versatile nature of PCP pathway.

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A compound PCP scheme underlies sequential rosettes-based cell intercalation

Cheng

Chen

et al. 2023

Development

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Sequential rosettes are a type of collective cell behavior recently discovered in the C. elegans embryo that mediates directional cell migration through sequential formation and resolution of multicellular rosettes involving the migrating cell and its neighboring cells along the way. Here we show that a Planar Cell Polarity (PCP)-based polarity scheme regulates sequential rosettes, which is distinct from the known mode of PCP regulation in multicellular rosettes during the process of convergent extension. Specifically, non-muscle myosin (NMY) localization and edge contraction are perpendicular to that of Van Gogh as opposed to colocalizing with Van Gogh. Further analyses suggest a two-component polarity scheme: one being the canonical PCP pathway with MIG-1/Frizzled and VANG-1/Van Gogh localized to the vertical edges, the other being MIG-1/Frizzled and NMY-2 localized to the midline/contracting edges. The NMY-2 localization and contraction of the midline edges are also required LAT-1/Latrophilin, an adhesion G protein-coupled receptor which has not been shown to regulate multicellular rosettes. Our results establish a distinct mode of PCP-mediated cell intercalation and shed light on the versatile nature of PCP pathway.

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Sequential Rosettes Drive C. elegans Ventral Nerve Cord Assembly

Cited by 3 publications

References 10 publications

Game of Tissues: How the Epidermis Thrones C. elegans Shape

Game of Tissues: How the Epidermis Thrones C. elegans Shape

A compound PCP scheme underlies sequential rosettes-based cell intercalation

A compound PCP scheme underlies sequential rosettes-based cell intercalation

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