“…Various methods have been used to estimate the total gas mass, including those employing virial mass [7,8], dust emission or extinction [9][10][11], γ-ray emission [12-14], 13 CO [6,15], and [C II] [16][17][18]. Most studies of the X CO factor consider an average value over a cloud and discuss the effects of cloud temperature, density, metallicity, and velocity dispersion on the X CO factor [19][20][21][22][23][24]. Pineda et al and Luo et al [19,25] found that the X CO factor in low-density regions without CO emission detections is six times higher than the average value in the Milky Way.…”