Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis

Yu, Wanqi; He, Xueqin; Yang, Zhipeng; Yang, Xiaotong; Xiao, Wei; Li, Rui; Xie, Rou; Qi, Lin; Gao, Huile

doi:10.1016/j.biomaterials.2019.119309

Cited by 162 publications

(130 citation statements)

References 62 publications

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“…[ 7,8 ] To improve the targeting potential of the anticancer drugs, nanoparticles have been heavily studied in drug loading and targeted delivery on cancer metastasis. [ 9–13 ] Generally, drug‐loaded nanoparticles need to be optimized for the size control and surface modification to enhance their retention time and targeting efficiency. [ 14–18 ] However, the feasibility of these nanoparticles in vivo is limited by several restrictions, such as high production costs, technical challenges, and poor metabolism in the body.…”

Section: Figurementioning

confidence: 99%

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong

Zhang

Xie

et al. 2020

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High delivery efficiency, prolonged drug release, and low systemic toxicity are effective weapons for drug delivery systems to win the battle against metastatic breast cancer. Herein, it is shown that Spirulina platensis (S. platensis) can be used as natural carriers to construct a drug‐loaded system for targeted delivery and fluorescence imaging‐guided chemotherapy on lung metastasis of breast cancer. The chemotherapeutic doxorubicin (DOX) is loaded into S. platensis (SP) via only one facile step to fabricate the DOX‐loaded SP (SP@DOX), which exhibits ultrahigh drug loading efficiency and PH‐responsive drug sustained release. The rich chlorophyll endows SP@DOX excellent fluorescence imaging capability for noninvasive tracking and real‐time monitoring in vivo. Moreover, the micrometer‐sized and spiral‐shaped SP carriers enable the as‐prepared SP@DOX to passively target the lungs and result in a significantly enhanced therapeutic efficacy on lung metastasis of 4T1 breast cancer. Finally, the undelivered carriers can be biodegraded through renal clearance without notable toxicity. The SP@DOX described here presents a novel biohybrid strategy for targeted drug delivery and effective treatment on cancer metastasis.

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Section: Figurementioning

confidence: 99%

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

Zhong

Zhang

Xie

et al. 2020

Small

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“…Doix et al indicated that the use of PDT-based DC vaccination before radiotherapy fails to prevent and control tumor growth, whereas PDT-based DC vaccination protocol in the peri-radiotherapy period could exhibit tumor growth inhibition, highlighting the significance of the coincidence of T cell activation and adjustments of the tumor microenvironment [288]. In another study, it was documented that a combination of photosensitizer pheophorbide A (PheoA), ROS-responsive paclitaxel dimer prodrug (PXTK), and anti-PD-L1 peptide dPPA exhibited significant antitumor and antimetastasis effect, emphasizing the value of the combination of chemotherapy, PDT, and immunotherapy in cancer management [289].…”

Section: Therapies Combining Photodynamic Therapy-induced Icdmentioning

confidence: 99%

Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

Asadzadeh

Safarzadeh

Safaei

et al. 2020

Cancers

117

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Cell death resistance is a key feature of tumor cells. One of the main anticancer therapies is increasing the susceptibility of cells to death. Cancer cells have developed a capability of tumor immune escape. Hence, restoring the immunogenicity of cancer cells can be suggested as an effective approach against cancer. Accumulating evidence proposes that several anticancer agents provoke the release of danger-associated molecular patterns (DAMPs) that are determinants of immunogenicity and stimulate immunogenic cell death (ICD). It has been suggested that ICD inducers are two different types according to their various activities. Here, we review the well-characterized DAMPs and focus on the different types of ICD inducers and recent combination therapies that can augment the immunogenicity of cancer cells.

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“…Lastly, a hyaluronidase‐responsive, size‐reducible nanophotosensitizer was developed by Yu and colleagues to explore the size‐dependent EPR effect. [ 52 ] They found that particles 150 nm in size, which are much bigger than those suggested by other researchers, exhibited the best tumor targeting and accumulation effects. [ 53 ] When these 150 nm‐sized nanoparticles were loaded with photosensitizer and combined with anti‐PD‐L1 blockade, they inhibited tumor growth and metastasis.…”

Section: Photodynamic Therapy and Its Immunomodulatory Effectmentioning

confidence: 99%

Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

Saklatvala

Mittal

et al. 2020

Advanced Science

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The past decade has seen the materialization of immune checkpoint blockade as an emerging approach to cancer treatment. However, the overall response and patient survival are still modest. Various efforts to study the “cancer immunogram” have highlighted complex biology that necessitates a multipronged approach. This includes increasing the antigenicity of the tumor, strengthening the immune infiltration in the tumor microenvironment, removing the immunosuppressive mechanisms, and reducing immune cell exhaustion. The coordination of these approaches, as well as the ability to enhance them through delivery, is evaluated. Due to their success in multiple preclinical models, external‐stimuli‐responsive nanoparticles have received tremendous attention. Several studies report success in distantly located tumor regression, metastases, and reoccurrence in preclinical mouse models. However, clinical translation in this space remains low. Herein, the recent advancement in external‐stimuli‐responsive nanoconstruct‐synergized immune checkpoint blockade is summarized, offering an industry perspective on the limitations of current academic innovations and discussing challenges in translation from a technical, manufacturing, and regulatory perspective. These limitations and challenges will need to be addressed to establish external‐stimuli‐based therapeutic strategies for patients.

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Sequentially responsive biomimetic nanoparticles with optimal size in combination with checkpoint blockade for cascade synergetic treatment of breast cancer and lung metastasis

Cited by 162 publications

References 62 publications

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

Biodegradable Microalgae‐Based Carriers for Targeted Delivery and Imaging‐Guided Therapy toward Lung Metastasis of Breast Cancer

Current Approaches for Combination Therapy of Cancer: The Role of Immunogenic Cell Death

Recent Progress of Potentiating Immune Checkpoint Blockade with External Stimuli—an Industry Perspective

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