SERCA pump as a novel therapeutic target for treating neurodegenerative disorders

Dahl, Russell; Bezprozvanny, Ilya

doi:10.1016/j.bbrc.2024.150748

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.150748

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SERCA pump as a novel therapeutic target for treating neurodegenerative disorders

Russell Dahl,

Ilya Bezprozvanny

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Cited by 2 publications

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ER stress as a sentinel mechanism for ER Ca2+ homeostasis

Makio,

Chen,

Simmen

2024

Cell Calcium

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ER stress as a sentinel mechanism for ER Ca2+ homeostasis

Makio,

Chen,

Simmen

2024

Cell Calcium

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Calcium channels as therapeutic targets in head and neck squamous cell carcinoma: current evidence and clinical trials

Lin,

Wang,

et al. 2024

Front. Oncol.

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Head and neck squamous cell carcinoma (HNSCC) originates from the mucosal epithelium of the oral cavity, pharynx, and larynx, and is marked by high rates of recurrence and metastasis. Calcium signaling is associated with the progression of HNSCC and the development of drug resistance. Changes in calcium ion flow can trigger severe pathophysiological processes, including malignant transformation, tumor proliferation, epithelial-mesenchymal transition, and apoptosis evasion. Calcium channels regulate and facilitate these processes. Remodeling of calcium signaling has become one of the most prevalent adaptive mechanisms in cancer cells. Preclinical and clinical evidence indicates that alterations in calcium signaling are crucial for the progression of HNSCC. This review examines the role of calcium channels in HNSCC development and evaluates current clinical trials targeting these channels to assess the feasibility of calcium signaling-based therapies for HNSCC.

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SERCA pump as a novel therapeutic target for treating neurodegenerative disorders

Cited by 2 publications

References 68 publications

ER stress as a sentinel mechanism for ER Ca2+ homeostasis

ER stress as a sentinel mechanism for ER Ca2+ homeostasis

Calcium channels as therapeutic targets in head and neck squamous cell carcinoma: current evidence and clinical trials

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