Serendipitous <i>N</i>,<i>S</i>-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

Aggarwal, Ranjana; Kumar, Prince; Hooda, Mona; Kumar, Suresh

doi:10.1039/d4ra00083h

RSC Adv.

2024

DOI: 10.1039/d4ra00083h

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Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

Ranjana Aggarwal,

Prince Kumar,

Mona Hooda

et al.

Abstract: An expedient construction of DNA groove binder; CF3-containing triazoles via regioselective reaction of trifluoromethyl-β-diketones with 3-mercapto[1,2,4]triazoles.

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Efficient synthesis of promising antidiabetic triazinoindole analogues via a solvent-free method: investigating the reaction of 1,3-diketones and 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione

Aggarwal,

Kumar,

Hooda

et al. 2025

Org. Biomol. Chem.

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Efficient synthesis of promising antidiabetic triazinoindole analogues via a solvent-free method: investigating the reaction of 1,3-diketones and 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione

Aggarwal,

Kumar,

Hooda

et al. 2025

Org. Biomol. Chem.

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Serendipitous N,S-difunctionalization of triazoles with trifluoromethyl-β-diketones: access to regioisomeric 1-trifluoroacetyl-3-aryl-5-(2-oxo-2-arylethylthio)-1,2,4-triazoles as DNA-groove binders

Abstract: An expedient construction of DNA groove binder; CF3-containing triazoles via regioselective reaction of trifluoromethyl-β-diketones with 3-mercapto[1,2,4]triazoles.

Cited by 1 publication

References 40 publications

Efficient synthesis of promising antidiabetic triazinoindole analogues via a solvent-free method: investigating the reaction of 1,3-diketones and 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione

Efficient synthesis of promising antidiabetic triazinoindole analogues via a solvent-free method: investigating the reaction of 1,3-diketones and 2,5-dihydro-3H-[1,2,4]triazino[5,6-b]indole-3-thione

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