SerenoCem™ granules in mastoid obliteration surgery: A 2‐year follow‐up case series of 55 patients to determine the risk of progressive bone resorption

Cherko, Matthew; Harrison, Laura; Chawdhary, Gaurav; Bull, Matthew; Bottrill, Ian; Aldren, C.

doi:10.1111/coa.13422

Cited by 2 publications

(5 citation statements)

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“…In three of fifteen patients (20%) who had serial CT scans, there was evidence of progression of the bony erosion. This is an unexpected and deeply concerning finding, which is in contrast with the results of the aforementioned study, 1 which showed that the erosion happens early after the operation and tends to stabilize over time. This finding may change our clinical decision‐making.…”

Section: Discussioncontrasting

confidence: 89%

“…As stated, there is only one other Group 1,2 that has analysed this topic; their studies showed that the bony re‐absorption usually happens early around the site of implant of the granules and tends to remain stable over time with no further progression.…”

Section: Discussionmentioning

confidence: 99%

“…Harrison et al 2 first published their findings in 2017 highlighting high rates of bony erosion, with many patients asymptomatic; a recent 2‐year follow‐up study 1 by the same Group has not identified any patients with progressive erosion on interval CT scans.…”

Section: Introductionmentioning

confidence: 99%

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SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion

Bandino

Kenway

Chatzimichalis

2020

Clinical Otolaryngology

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion

Bandino

Kenway

Chatzimichalis

2020

Clinical Otolaryngology

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“…This was seen with CerenoSem granules, a bone binding bioactive material, that was unfortunately voluntarily removed from the market due to adjacent bone erosion. 43 An initial postoperative CT of the temporal bones found radiological evidence of bony erosion in 76.4% of the patients implanted with the material. However, a 2-year interval CT scan found no further radiologic bone erosion with the remaining patients that still had the implant in situ.…”

Section: Synthetic Materialsmentioning

confidence: 99%

“…Another complication of synthetic materials is bone or material resorption. This was seen with CerenoSem granules, a bone binding bioactive material, that was unfortunately voluntarily removed from the market due to adjacent bone erosion 43 . An initial postoperative CT of the temporal bones found radiological evidence of bony erosion in 76.4% of the patients implanted with the material.…”

Section: Considerations When Obliterating the Mastoid Cavity Based On...mentioning

confidence: 99%

Materials used for mastoid obliteration and its complications: a systematic review

Choong

Kwok

Shen

et al. 2022

ANZ Journal of Surgery

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Objective: The objectives of this review are to identify the types of materials with their associated complications and respective considerations when used to obliterate the mastoid cavity. Methods: A systematic search was performed across PubMed, Embase, Medline and Cochrane databases from January 2009 to January 2020 for randomized controlled trials and observational studies of patients that underwent mastoid obliteration. Studies that fulfilled the inclusion criteria were screened and scored according to the MINORS and relevance scores to determine final inclusion. Types of complications were grouped into minor and major complications based on the Clavien-Dindo classification. Results: Two thousand five hundred and seventy-eight ears were evaluated. There were a total of 165 (7.9%) minor and 142 (6.8%) major complications in the autologous group. Overall complication rate is 14.8%. The major complications were largely recurrent and residual disease requiring revision surgery. There were 10 (18.5%) minor complications and three (5.6%) major complications in the allogenic group. The cumulative complications risk is 24%. For the synthetic group, there were 39 (8.0%) minor and 34 (7.6%) major complications. The cumulative complication rate is 16.6%. Conclusion: Current evidence on materials for mastoid obliteration has been evolving. Each material has its strengths and limitations. The trend over the last decade favours the use of autologous materials. The principle of using a material remains being cautious of not reimplanting skin that can lead to the development of a cholesteatoma. The choice of materials is dependent on patient factors as well as the surgeons' preference and experience. 7 (31.8) 1 (4.5) † Park study is tabulated in the autologous and synthetic group as well as it looked at different group of materials. ‡ No specific details provided..

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SerenoCem™ granules in mastoid obliteration surgery: A 2‐year follow‐up case series of 55 patients to determine the risk of progressive bone resorption

Cited by 2 publications

References 1 publication

SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion

SerenoCem™ granules: A retrospective analysis of 43 patients and identification of a subset with progressive erosion

Materials used for mastoid obliteration and its complications: a systematic review

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