Serial 3-Dimensional Computed Tomography and a Novel Method of Volumetric Analysis for the Evaluation of the Osteo-Odonto-Keratoprosthesis

Sipkova, Zuzana; Lam, Fook Chang; Francis, I R; Herold, J; Liu, Christopher

doi:10.1097/ico.0b013e31825425d0

Cited by 17 publications

(5 citation statements)

References 14 publications

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“…In a retrospective study, Sipkova et al applied an automated algorithm called “Advanced Lung Analysis Software” on UK national cohort of OOKP patients and analyzed laminar volumes objectively from the serial multidimensional CT images. 99 This method is reproducible and identified resorption earlier than clinical examination in 60% of the patients. Early detection of resorption could help the clinicians to monitor the rate of bone loss and enables to intervene at the correct opportunity.…”

Section: Osteo-odonto-keratoprosthesis (Ookp)mentioning

confidence: 87%

Keratoprostheses for corneal blindness: a review of contemporary devices

Avadhanam¹,

Smith²,

Liu³

2015

OPTH

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According to the World Health Organization, globally 4.9 million are blind due to corneal pathology. Corneal transplantation is successful and curative of the blindness for a majority of these cases. However, it is less successful in a number of diseases that produce corneal neovascularization, dry ocular surface and recurrent inflammation, or infections. A keratoprosthesis or KPro is the only alternative to restore vision when corneal graft is a doomed failure. Although a number of KPros have been proposed, only two devices, Boston type-1 KPro and osteo-odonto-KPro, have came to the fore. The former is totally synthetic and the latter is semi-biological in constitution. These two KPros have different surgical techniques and indications. Keratoprosthetic surgery is complex and should only be undertaken in specialized centers, where expertise, multidisciplinary teams, and resources are available. In this article, we briefly discuss some of the prominent historical KPros and contemporary devices.

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Section: Osteo-odonto-keratoprosthesis (Ookp)mentioning

confidence: 87%

Keratoprostheses for corneal blindness: a review of contemporary devices

Avadhanam¹,

Smith²,

Liu³

2015

OPTH

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“…For postoperative assessment of the graft concerning the bone and dentin tissue, 3D radiographic imaging is desirable. Sipkova et al 10 have calculated the volume of OOKP. This might be sensible in some cases.…”

Section: Discussionmentioning

confidence: 99%

Cone-Beam Computed Tomography for Planning and Assessing Surgical Outcomes of Osteo-Odonto-Keratoprosthesis

Berg

Dagassan-Berndt

Goldblum

et al. 2015

Cornea

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“…Detection in our cases was performed by obtaining a thin-layer CT scan of the orbit once a year to determine loss of material. Sipkova et al 36 published a laminar volume measurement to standardize the grade of resorption in CT scans. This suggested volume measurement was not established for our cohort.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Keratoprosthesis With Biological Haptic: A Review of 25 Years of Single-Center Surgeries

Angerer,

Weller,

Kruse

et al. 2024

Cornea

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Purpose: To study the outcome of eyes that underwent surgery for keratoprosthesis with a biological haptic, osteo-odonto-keratoprosthesis (OOKP) or tibia keratoprosthesis, by a single surgeon over a time span of more than 25 years. Methods: One hundred thirty eyes that had received a keratoprosthesis with a biological haptic between 1994 and 2022 by a single surgeon were included in this retrospective analysis. Main outcome parameters were postoperative best corrected visual acuity, postoperative refractive error, postoperative complications, anatomical and functional survival of the prosthesis as well as comparison of subgroups of the 2 different types (OOKP n = 78; tibia keratoprosthesis n = 52) of keratoprostheses, and subgroup analysis of different indications for surgery. Patients were examined every 6 months. Results: The longest follow-up was 25.8 years. Reasons for implantation were graft-vs-host disease (6.9%), vascularized corneas and dry eye (22.9%), physical or chemical burns (29.8%), Stevens–Johnson syndrome (9.9%), and ocular cicatricial pemphigoid (30.5%). The functional success rate with postoperative visual acuity of better than 0.7 log MAR was achieved by 56.9%. The OOKP subgroup showed a better mean visual outcome. 14 keratoprostheses (10.7%) had to be explanted over the whole time span. In the time leading to explantation, refraction showed a statistically significant myopic shift when compared with the non-explanted prosthesis. Anatomical survival rates were better for the OOKP in the first 12 years after implantation. Conclusions: The study shows that keratoprosthesis with a biological haptic has favorable long-term outcomes. The retention rate stayed very high with excellent functional outcomes.

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Serial 3-Dimensional Computed Tomography and a Novel Method of Volumetric Analysis for the Evaluation of the Osteo-Odonto-Keratoprosthesis

Cited by 17 publications

References 14 publications

Keratoprostheses for corneal blindness: a review of contemporary devices

Keratoprostheses for corneal blindness: a review of contemporary devices

Cone-Beam Computed Tomography for Planning and Assessing Surgical Outcomes of Osteo-Odonto-Keratoprosthesis

Long-Term Outcomes of Keratoprosthesis With Biological Haptic: A Review of 25 Years of Single-Center Surgeries

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