Serial Assessment of Natriuretic Peptides in Patients Undergoing Interventional Closure of the Left Atrial Appendage

Luani, Blerim; Rauwolf, Thomas; Groscheck, Thomas; Tanev, Ivan; Herold, Joerg; Isermann, Berend; Schmeißer, Alexander; Braun-Dullaeus, Rüdiger C.

doi:10.1016/j.hlc.2017.07.001

Cited by 16 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the speci c changes of ANP and BNP postoperative and the actual mechanism of perioperative changes in homeostasis are still unclear. In our study, although BNP was only measured in some patients, it still showed a trend that was different from past studies 21,22,23 . In addition, a signi cant increase in glucose was observed among most of the patients, while Lakkureddy et 9 announced that insulin signi cantly increased in patients who underwent epicardial LAAC procedure at 24 hours postoperation and 3 months follow-up when compared with the baseline level.…”

Section: Discussioncontrasting

confidence: 99%

The Effects of Stand-alone Thoracoscopic Left Atrial Appendage Clipping on Blood Pressure and Electrolytes

Chen

2022

Preprint

View full text Add to dashboard Cite

Background: The natriuretic peptides secreted from the left atrial appendage could affect patients' system homeostasis by antagonizing the renin-angiotensin-aldosterone system. Thus, the epicardial LAA closure may induce unwanted hyponatremia and hypotension cause of isolating the LAA from the circulation. In this study, we aim to explore this phenomenon following stand-alone thoracoscopic LAA clipping and provide a hypothesis of the potential mechanism.Methods: This was a retrospective, observational study including 27 stroke patients with AF who underwent thoracoscopic LAA clipping. Electrolyte, BP, heart rate, and BNP were measured before the procedure, immediately after the device release, at 1st day, 2nd day postoperation, and 24h before discharge. Fluid amounts were only monitored postoperatively.Results: There was a significantly acute reduction in serum sodium (mmol/L) at all the timepoints postoperation when compared to baseline. The blood pressure has no significant difference when compared with baseline levels at discharge.Conclusion: Epicardial LAA clipping induce an acute decrease in serum sodium and MAP postoperation which indicates to the surgeons that the postoperative intake fluid amounts and serum sodium level management should be appropriate. Although the fluctuation of blood pressure of patients was observed perioperative, it has returned to the baseline level till discharge and the accurate and further mechanisms still need more study.

show abstract

Section: Discussioncontrasting

confidence: 99%

The Effects of Stand-alone Thoracoscopic Left Atrial Appendage Clipping on Blood Pressure and Electrolytes

Chen

2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Launi et al demonstrated that the sodium and potassium levels had not significantly changed in the 6 and 24 weeks following the WATCHMAN procedure, but no acute levels were measured after the procedure [ 5 ]. Maybrook et al demonstrated a decrease in serum sodium levels immediately after the epicardial LAAC procedure that normalized at six months [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: LAA HOMEOSTASIS-2

Bartuś

Kanuri

Litwinowicz

et al. 2022

JCM

View full text Add to dashboard Cite

Background: Recent data suggest that epicardial left atrial appendage closure (LAAC) is associated with several short-term neurohormonal effects. However, the long-term effects are currently unknown. Objective: To investigate the effects of percutaneous epicardial left atial appendage (LAA) exclusion using LARIAT on neurohormonal profiles at long-term follow-up. Methods: In a prospective single centre study, 60 patients with long-standing, persistent atrial fibrillation (AF) LARIAT were treated. The major hormones of the adrenergic system, renin-angiotensin-aldosterone system (RAAS), and natriuretic peptides were assessed before the intervention and at regular intervals during the following two years. Results: In patients with epicardial LAAC, atrial natriuretic peptide (ANP) levels were significantly increased from baseline at 24 h and decreased at 7 days, 1 month, and 3 months, while remaining unchanged at 12 and 24 months. Noradrenaline levels were significantly lower at 24 h, 7 days, 1 month, 6 months, 12 months, and 24 months, while epinephrine levels decreased significantly at 1 month, 6 months, 12 months, and 24 months. Plasma renin activity significantly decreased at 7 days, 1 month, 6 months, 12 months, and 24 months, while aldosterone levels significantly decreased at 6 months, 12 months, and 24 months. Endothelin-1 and vasopressin showed a significant increase and decrease, respectively, at 24 h, 7 days, 1 month, 6 months, 12 months, and 24 months. There was also a significant decrease in systolic and diastolic blood pressure at 3 months, 6 months, 1 year, and 2 years after the intervention. Conclusions: Epicardial LAAC in AF patients is associated with persistent neurohormonal changes favouring blood pressure reduction.

show abstract

“…This LA remodeling may be explained by the alteration of LAA function after LAAC. Previous studies have shown that there was a decrease in ANP concentration after percutaneous LAA device closure for ischemic stroke prevention [15,17].…”

Section: Discussionmentioning

confidence: 97%

“…Interestingly, percutaneous LAAC with devices for ischemic stroke prevention has been shown to be associated with a significant reduction in plasma ANP [16,17]. Therefore, both LAA mechanical and endocrine functions will be altered after LAAC.…”

Section: Introductionmentioning

confidence: 99%

Impact of left atrial appendage closure on cardiac functional and structural remodeling: A difference-in-difference analysis of propensity score matched samples

et al. 2019

View full text Add to dashboard Cite

show abstract

Serial Assessment of Natriuretic Peptides in Patients Undergoing Interventional Closure of the Left Atrial Appendage

Cited by 16 publications

References 33 publications

The Effects of Stand-alone Thoracoscopic Left Atrial Appendage Clipping on Blood Pressure and Electrolytes

The Effects of Stand-alone Thoracoscopic Left Atrial Appendage Clipping on Blood Pressure and Electrolytes

Long Term Impact of Epicardial Left Atrial Appendage Ligation on Systemic Hemostasis: LAA HOMEOSTASIS-2

Impact of left atrial appendage closure on cardiac functional and structural remodeling: A difference-in-difference analysis of propensity score matched samples

Contact Info

Product

Resources

About