Serial Contrast-Enhanced Cardiac Magnetic Resonance Imaging Demonstrates Regression of Hyperenhancement Within the Coronary Artery Wall in Patients After Acute Myocardial Infarction

Ibrahim, Tareq; Makowski, Moritz; Jankauskas, Antanas; Maintz, David; Karch, Martin R.; Schachoff, Sylvia; Manning, Warren J.; Schömig, Albert; Schwaiger, Markus; Botnar, René M.

doi:10.1016/j.jcmg.2008.12.029

Cited by 116 publications

(88 citation statements)

References 33 publications

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“…The findings of this study regarding strong enhancement of intracranial plaques within 4 weeks of ischemic stroke are similar to the findings for extracranial plaques and may therefore suggest that intracranial enhancement is a marker of inflammation. Inflammation and, therefore, plaque enhancement are expected to decrease in the chronic phase for extracranial vessels, 3,12 and this was also seen in this study.…”

Section: Discussionsupporting

confidence: 75%

“…2 In addition to serum markers, the use of noninvasive imaging modalities including CT, MR imaging, and nuclear medicine for the characterization of plaque inflammation has been gaining interest over the past several years. 3,[10][11][12][13][14][15][16][17] Investigations with FDG-PET imaging have shown that it may be used as a surrogate marker for inflammation of plaques, as patients with the highest levels of FDG uptake had the greatest concentrations of inflammatory biomarkers. 10,11 MR imaging characterization of extracranial atherosclerotic plaque has been well studied and well established.…”

Section: Discussionmentioning

confidence: 99%

“…3,14 One study using cardiac MR imaging in patients with acute myocardial infarction demonstrated enhancement of the coronary vessel wall present during the acute phase, with a decrease in enhancement after 3 months in the chronic phase in parallel with levels of C-reactive protein. 12 MR imaging studies of the extracranial carotid arteries have identified features of an atherosclerotic plaque that may convey increased risk of thromboembolic events, even in cases with less than 50% luminal stenosis. 5 Extracranial large artery inflammatory plaques have been reported to demonstrate asymmetric wall thickening with gadolinium enhancement.…”

Section: Discussionmentioning

confidence: 99%

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Intracranial Atherosclerotic Plaque Enhancement in Patients with Ischemic Stroke

Skarpathiotakis

Mandell

Swartz

et al. 2012

AJNR Am J Neuroradiol

130

117

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BACKGROUND AND PURPOSE:Inflammation of an atherosclerotic plaque is a well-known risk factor in the development of ischemic stroke and myocardial infarction. MR imaging is capable of characterizing inflammation by assessing plaque enhancement in both extracranial carotid arteries and coronary arteries. Our goal was to determine whether enhancing intracranial atherosclerotic plaque was present in the vessel supplying the territory of infarction by using high-resolution vessel wall MR imaging.

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Section: Discussionsupporting

confidence: 75%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Intracranial Atherosclerotic Plaque Enhancement in Patients with Ischemic Stroke

Skarpathiotakis

Mandell

Swartz

et al. 2012

AJNR Am J Neuroradiol

130

117

View full text Add to dashboard Cite

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“…A contrast-enhanced approach can also be used for plaque characterization with CMR. Studies using clinically approved extracellular contrast agents showed that uptake in the coronary artery wall is non-specific and could be associated with both atherosclerotic plaque composition and inflammation in patients with stable CAD or acute coronary syndrome [80,81]. Enhancement with newly developed albumin binding and iron oxide-based contrast agents is associated with increased endothelial permeability and thus can be used for coronary wall imaging [82][83][84][85].…”

Section: Coronary Artery Wall Imagingmentioning

confidence: 99%

Cardiac MR Assessment of Coronary Arteries

Hamdy

Ishida

Sakuma

2017

Cardiovasc Imaging Asia

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Imaging of coronary arteries with magnetic resonance has undergone undeniable progress during the past two decades. Although coronary computed tomography angiography detects coronary artery disease (CAD) with excellent diagnostic accuracy, the inevitable exposure to ionizing radiation and iodinated contrast administration make it less appealing in certain patient populations. Coronary magnetic resonance angiography (MRA) is now performed mostly as a whole heart, free breathing, three-dimensional study. Several factors influence quality and speed of the scan, including use of the appropriate pulse sequence according to the strength of the magnetic field, cardiac and respiratory gating, preparation pulses, multi-channel cardiac coils, parallel imaging, and contrast material injection. The use of coronary MRA is well established in coronary artery anomalies and aneurysms. While diagnostic performance has also improved markedly for the detection of CAD, coronary MRA is not yet a routine clinical study. However, coronary MRA is expected to be play a major role in the near future due to continuous research and technical achievements.

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“…In clinical application, native MRI can differentiate among the morphological components of atherosclerotic plaques in the carotids, the aorta as well as coronary arteries [7 -9]. Additional information regarding plaque composition can be obtained by administering clinically-approved non-specific contrast agents [10]. Specific molecular probes that selectively highlight certain molecules or cells allow the visualization and characterization of pathological processes on the molecular level, thus enhancing the detection of early stages of disease, and improving treatment planning and therapy monitoring.…”

Section: Key Pointsmentioning

confidence: 99%

Molecular Imaging in Cardiovascular Diseases

Botnar

Ebersberger

Noerenberg

et al. 2015

Fortschr Röntgenstr

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Cardiovascular diseases remain the leading cause of morbidity and mortality in industrialized and developing countries. In clinical practice, the in-vivo identification of atherosclerotic lesions, which can lead to complications such as heart attack or stroke, remains difficult. Imaging techniques provide the reference standard for the detection of clinically significant atherosclerotic changes in the coronary and carotid arteries. The assessment of the luminal narrowing is feasible, while the differentiation of stable and potentially unstable or vulnerable atherosclerotic plaques is currently not possible using non-invasive imaging. With high spatial resolution and high soft tissue contrast, magnetic resonance imaging (MRI) is a suitable method for the evaluation of the thin arterial wall. In clinical practice, native MRI of the vessel wall already allows the differentiation and characterization of components of atherosclerotic plaques in the carotid arteries and the aorta. Additional diagnostic information can be gained by the use of non-specific MRI contrast agents. With the development of targeted molecular probes, that highlight specific molecules or cells, pathological processes can be visualized at a molecular level with high spatial resolution. In this review article, the development of pathophysiological changes leading to the development of the arterial wall are introduced and discussed. Additionally, principles of contrast enhanced imaging with non-specific contrast agents and molecular probes will be discussed and latest developments in the field of molecular imaging of the vascular wall will be introduced. Key Points: ??Molecular magnetic resonance imaging has great potential to improve the in vivo characterization of atherosclerotic plaques. ??Based on the molecular information is feasible to enable a better differentiation of stable and unstable (vulnerable) atherosclerotic plaques. Citation Format: ??Botnar RM, Ebersberger H, Noerenberg D et?al. Molecular imaging in cardiovascular diseases. Fortschr R?ntgenstr 2015; 187: 92???101

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Serial Contrast-Enhanced Cardiac Magnetic Resonance Imaging Demonstrates Regression of Hyperenhancement Within the Coronary Artery Wall in Patients After Acute Myocardial Infarction

Cited by 116 publications

References 33 publications

Intracranial Atherosclerotic Plaque Enhancement in Patients with Ischemic Stroke

Intracranial Atherosclerotic Plaque Enhancement in Patients with Ischemic Stroke

Cardiac MR Assessment of Coronary Arteries

Molecular Imaging in Cardiovascular Diseases

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