Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre‐eclampsia: a longitudinal study

López-Alarcón, Mardya; Montalvo-Velarde, Irene; Vital-Reyes, VS; Hinojosa-Cruz, JC; Leaños‐Miranda, Alfredo; Martínez-Basila, Azucena

doi:10.1111/1471-0528.13516

Cited by 30 publications

(21 citation statements)

References 23 publications

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“…Asymmetric Dimethylarginine [ADMA], an inhibitor of nitric oxide synthase has low plasma levels and exhibits inverse relationship with NO levels in first Open Journal of Obstetrics and Gynecology trimester of normal pregnancy [11] [12]. However, many studies have reported the elevated levels of ADMA in the first trimester even before the development of preeclampsia [13] [14] [15].…”

Section: Introductionmentioning

confidence: 99%

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Gadde¹,

Dayanand²,

Sheela³

2018

OJOG

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Background: Preeclampsia is a worldwide pregnancy complication, and early identification of patients with an increased risk is one of the key goals in obstetrics. First trimester screening is crucial over the second trimester for understanding the early onset of the disorder, with basal levels of the biochemical parameters associated with the underlying placentation process. Objective: The study aims to assess the levels of serum biochemical markers in pregnant women at first trimester, to evaluate statistical significance and correlation of the values in support of trophoblastic cell integrity, endothelial function and oxidative stress. Materials and Methods: A longitudinal study was conducted on 86 pregnant women of age group 20 -35 years, Primigravida with singleton pregnancy who visited prenatal check up between 11 -13 weeks of gestation. Maternal sera was collected for screening Placental protein 13 (PP13), Caspase 3, Asymmetric dimethylarginine (ADMA), Nitric oxide (NO) by ELISA. Xanthine oxidase (XO) activity was assayed spectrophotometrically. Calcium and Uric acid (UA) were measured by dry chemistry analyser. Results: The mean ± SD values for mean arterial pressure (MAP) are 108.4 ± 18.9, UA 2.01 ± 0.85, Total oxidant status (TOS) 12.83 ± 5.17, Total antioxidant capacity (TAC) 24.

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Section: Introductionmentioning

confidence: 99%

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Gadde¹,

Dayanand²,

Sheela³

2018

OJOG

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“…It is associated with endothelial dysfunction in the placenta reducing placental perfusion as seen in preeclampsia. There are reports presenting increased ADMA concentration in first trimester that could predict preeclampsia [5].…”

Section: Biomedical Research 2019; 30 (2): 319-324mentioning

confidence: 99%

Placental protein 13 and asymmetric dimethyl arginine for early assessment of preeclampsia

Gadde¹,

Dayan²,

Sheela³

2019

biomedicalresearch

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Objective: To evaluate serum levels of biomarkers as early indicators of onset of preeclampsia during pregnancy. Method: A nested case-control study was conducted among the pregnant women who visited for antenatal checkup at R.L. Jalappa Research Center, Kolar between August 2017 and May 2018. Serum levels of placental protein 13 (PP13), asymmetric dimethylarginine (ADMA), nitric oxide and caspase-3 which represents placentation and endothelial function were measured and compared between trimesters. Results and Discussion: There were 86 pregnant women enrolled at first trimester, the baseline values of women who developed preeclampsia were PP13 (477.54 ± 62.72 pg/ml), ADMA (21.06 ± 19.42 ng/ml), nitric oxide (3.71 ± 2.76 nmol/μL) and caspase-3 (6.15 ± 0.55 ng/ml). In the second trimester on follow up, the mean serum concentration of PP13 was 530.64 ± 69.10 pg/ml in preeclampsia versus 518.26 ± 49.33 pg/ml in normal pregnancy. The mean serum concentration of ADMA was 73.43 ± 30.95 ng/ml and nitric oxide 4.10 ± 2.70 nmol/μL in preeclampsia versus 21.06 ± 19.42 ng/ml and 4.85 ± 2.19 nmol/μL in normal pregnancy. The mean serum concentration of caspase-3 in preeclampsia was 22.65 ± 0.91 ng/ml versus normal pregnancy 18.45 ± 2.62 ng/ml were recorded. In preeclampsia, PP13 was positively correlated with nitric oxide and negatively correlated with ADMA. Conclusion: Decreased PP13, nitric oxide and elevated ADMA in first trimester and increased PP13, ADMA and decreased nitric oxide at second trimester reflects altered placentation and endothelial function.

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“…Serial measurements of their concentrations may be useful to identify women at risk [26]. [27], it represses production of VEGF receptors in mesenchymal stem cells derived from the decidua (MSCs), and induces cell cycle arrest in the transition G0/G1 [28].…”

Section: Adma and Homocysteinementioning

confidence: 99%

Pharmacological Opportunities for Prevention of Preeclampsia

García-Benavides¹,

Molina²,

Vega³

et al. 2017

Obstetrics

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Preeclampsia (PE) is a disorder that occurs during pregnancy, it has an estimated worldwide prevalence of 5-8%, being one of the leading causes of maternal and perinatal morbidity and mortality. Currently, diferent diagnostic criteria exist, however, due to its complexity; the clinical presentation that makes up this syndrome could make its presence unclear. The pathophysiology of PE has been recently postulated and divided into three processes: inadequate uterine remodeling, placental dysfunction and maternal endothelial dysfunction. Despite the advances in the treatment of PE, the outcome of the medical interventions has failed to decrease the morbidity and mortality of this disease. The main reason might be the multifactorial origin of pathogenic processes that lead to the development of PE. That is why treatment is focused on the prevention of PE in patients that might present the risk before developing it late in pregnancy. The knowledge of the pathophysiological factors that trigger the processes that culminate in the presentation of PE, is key for prevention of this disease. However, the origin of these processes is poorly understood. It may be atributed to the ethical considerations that come with the study of these population of patients compared with the study of nonpregnant women.

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Serial determinations of asymmetric dimethylarginine and homocysteine during pregnancy to predict pre‐eclampsia: a longitudinal study

Cited by 30 publications

References 23 publications

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Maternal Serum Biochemical Indicators of Trophoblastic Cell and Endothelial Function at First Trimester of Pregnancy

Placental protein 13 and asymmetric dimethyl arginine for early assessment of preeclampsia

Pharmacological Opportunities for Prevention of Preeclampsia

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