Serial EEG findings in sporadic and iatrogenic Creutzfeldt–Jakob disease

Wieser, Heinz Gregor; Schwarz, Urs; Blättler, Thomas; Bernoulli, Christoph; Sitzler, Matthias; Stoeck, Katharina; Glatzel, Markus

doi:10.1016/j.clinph.2004.05.032

Cited by 59 publications

(32 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…55 The typical appearance for sCJD is that of a 1/second periodic triphasic sharp wave complex. The simple sharp waves can be classic triphasic, biphasic, or mixed.…”

Section: Eeg Findingsmentioning

confidence: 99%

Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy

Manix

Kalakoti

Henry

et al. 2015

FOC

157

160

View full text Add to dashboard Cite

Creutzfeldt-Jakob disease (CJD) is a rare neurodegenerative condition with a rapid disease course and a mortality rate of 100%. Several forms of the disease have been described, and the most common is the sporadic type. The most challenging aspect of this disease is its diagnosis—the gold standard for definitive diagnosis is considered to be histopatho-logical confirmation—but newer tests are providing means for an antemortem diagnosis in ways less invasive than brain biopsy. Imaging studies, electroencephalography, and biomarkers are used in conjunction with the clinical picture to try to make the diagnosis of CJD without brain tissue samples, and all of these are reviewed in this article. The current diagnostic criteria are limited; test sensitivity and specificity varies with the genetics of the disease as well as the clinical stage. Physicians may be unsure of all diagnostic testing available, and may order outdated tests or prematurely request a brain biopsy when the diagnostic workup is incomplete. The authors review CJD, discuss the role of brain biopsy in this patient population, provide a diagnostic pathway for the patient presenting with rapidly progressive dementia, and propose newer diagnostic criteria.

show abstract

“…55 The typical appearance for sCJD is that of a 1/second periodic triphasic sharp wave complex. The simple sharp waves can be classic triphasic, biphasic, or mixed.…”

Section: Eeg Findingsmentioning

confidence: 99%

Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy

Manix

Kalakoti

Henry

et al. 2015

FOC

157

160

View full text Add to dashboard Cite

show abstract

“…In typical sCJD, these findings are expected in the frontotemporal area, but as this is the Heidenhain variant, this patient's EEG had maximal potentials over the occiput matching his primary symptoms and other imaging findings (Figure 1). The progression ends with readings of coma in preterminal EEG recordings [10].…”

Section: Discussionmentioning

confidence: 99%

Imaging and EEG findings of Rare Heidenhain Variant of Creutzfeldt-Jakob Disease

Jens¹,

Strauß

Lee

et al. 2015

J Neu neurol

View full text Add to dashboard Cite

show abstract

“…Thus, the time to take EEG examination is extremely important. [31,32] In the regular EEG examination, the sensitivity of PSWCs is 64-66%, [32,33] and the specificity is about 80%.…”

Section: Eegmentioning

confidence: 99%

Developments in auxiliary examination of Creutzfeldt-Jakob disease

Zhao¹,

Jiang²,

Zhang³

2017

View full text Add to dashboard Cite

How to cite this article: Zhao W, Jiang JJ, Zhang JT. Developments in auxiliary examination of Creutzfeldt-Jakob disease. Neuroimmunol Neuroinflammation 2017;4:136-44.Creutzfeldt-Jakob disease (CJD), which is caused by prion scrapie protein, is a rare, chronic, transmissible and fatal disease. Clinical manifestations of CJD include rapidly progressive dementia, cerebellar ataxia, visual disturbance, as well as pyramidal and extrapyramidal tract signs. Four subtypes of CJD have been reported, including sporadic, familial or genetic, iatrogenic and variant. Given the infectiousness and high mortality of the disease, it is imperative that earlier and more accurate diagnostic methods are developed. In the past years, 14-3-3 protein testing and periodic sharp wave complexes in electroencephalogram have been widely used in CJD clinical diagnosis; and the abnormal hyper-intensity in diffusion weighted imaging has also been used. Recently, there has been a focus on the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography. New findings of potential biomarkers in cerebrospinal fluid and decreases in diffusion tensor imaging measures have emerged as having an association with CJD. Magnetic resonance spectroscopy has also drawn attention as an emerging method for diagnosis. In this review, the progress in auxiliary examinations of CJD is discussed and the potential, future diagnostic methods are introduced. Key words:Creutzfeldt-Jakob disease, 14-3-3 protein, electroencephalogram, diffusion weighted imaging, diffusion tensor imaging, magnetic resonance spectroscopy, 18F-fluorodeoxyglucose positron emission tomography/computed tomography Topic: Infectious Disease of Central Nervous SystemThis is an open access article distributed under the terms of the Creative Commons AttributionNonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms. For reprints contact: service@oaepublish.comOpen Access Zhao et al. Neuroimmunol Neuroinflammation 2017;4:136-44 DOI: 10.20517/23474:136-44 DOI: 10.20517/ -8659.2017

show abstract

Serial EEG findings in sporadic and iatrogenic Creutzfeldt–Jakob disease

Cited by 59 publications

References 17 publications

Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy

Creutzfeldt-Jakob disease: updated diagnostic criteria, treatment algorithm, and the utility of brain biopsy

Imaging and EEG findings of Rare Heidenhain Variant of Creutzfeldt-Jakob Disease

Developments in auxiliary examination of Creutzfeldt-Jakob disease

Contact Info

Product

Resources

About