Serial fibrin monomer and D-dimer plasma levels measurements can capture thrombotic complications in critically ill COVID-19 patients: A prospective observational study

Hardy, Michaël; Michaux, Isabelle; Bulpa, Pierre; Schonau, B.; Nicolay, B.; Maistre, Emmanuel de; Godon, Alexandre; Lecompte, T.; Mullier, François

doi:10.1016/j.thromres.2022.11.026

Cited by 3 publications

(3 citation statements)

References 26 publications

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Section: D-dimers and Fibrin Monomersmentioning

confidence: 99%

“…Moreover, the peaks were often transient, and the levels decreased more rapidly than those of D-dimers [56]. The short half-life of fibrin monomers requires daily dosing to detect these abrupt hypercoagulability states [57]. Early reports from European intensive care units highlighted a higher incidence of thromboembolic events in severe COVID-19 patients compared to historical cases of severe infectious diseases, despite standard anticoagulant prophylaxis [1][2][3]7].…”

Section: D-dimers and Fibrin Monomersmentioning

confidence: 99%

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COVID-19 and the Concept of Thrombo-Inflammation: Review of the Relationship between Immune Response, Endothelium and Coagulation

de Maistre,

Savard,

Guinot

2023

JCM

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COVID-19, caused by the SARS-CoV-2 virus, has revealed a complex interplay between inflammation and coagulation, leading to the emergence of the concept of thrombo-inflammation. This concept recognizes that COVID-19 is not solely a respiratory illness, but a systemic disease with significant vascular and hematological components. COVID-19 is associated with an unusual prothrombotic state, with intense endothelial activation leading to vasculopathy, cytokine storm, complement system activation and a hypercoagulability state (the activation of platelets and the coagulation cascade, impaired fibrinolysis). The aim of this review is to discuss the different pathological pathways described in COVID-19 that lead to thromboembolic events. Widespread vaccination and post-COVID-19 immunization allows control over the severity of this pandemic. A better understanding of the pathophysiology of COVID-19 can improve the management of frail patients who are hospitalized in intensive care units.

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Section: D-dimers and Fibrin Monomersmentioning

confidence: 99%

Section: D-dimers and Fibrin Monomersmentioning

confidence: 99%

COVID-19 and the Concept of Thrombo-Inflammation: Review of the Relationship between Immune Response, Endothelium and Coagulation

de Maistre,

Savard,

Guinot

2023

JCM

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“…In the early stages of the pandemic, some experts proposed evaluating FM levels in COVID-19 patients ( 13 ). Despite these expert recommendations, less data are available on the relevance of FM evaluation during COVID-19 ( 14 – 19 ) in contrast to D-dimer. None of the studies made a strong case for a clear-cut clinical use and a daily-life evaluation.…”

Section: Introductionmentioning

confidence: 99%

Fibrin monomers evaluation during hospitalization for COVID-19 is a predictive marker of in-hospital mortality

Smadja

Gendron

Philippe

et al. 2023

Front. Cardiovasc. Med.

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BackgroundCoagulopathy is one of the main triggers of severity and worsening of Coronavirus disease 2019 (COVID-19) particularly in critically ill patients. D-dimer has been widely used to detect COVID-19 coagulation disorders and has been correlated with outcomes such as disease severity and in-hospital mortality. Involvement of other fibrin degradation products, particularly fibrin monomers (FM), remains an ongoing question.MethodsWe performed a monocentric study of adult patients with COVID-19, who were admitted either in the medical ward (MW) or in the intensive care unit (ICU) and who had FM measurements performed on them during the first wave of COVID-19 outbreak. We analyzed the positivity of FM levels (FM > 7 µg/mL) to assess the ability of FM monitoring during the first days of hospitalization to predict COVID-19 outcomes.ResultsIn our cohort, 935 FM measurements were performed in 246 patients during their first 9 days of hospitalization. During patient follow-up, the FM levels were higher in patients admitted directly to the ICU than in those admitted to the MW. Moreover, we observed significantly increased levels of FM in patients when the data were stratified for in-hospital mortality. At hospital admission, only 27 (11%) patients displayed a positive value for FM; this subgroup did not differ from other patients in terms of severity (indicated by ICU referral at admission) or in-hospital mortality. When analyzing FM positivity in the first 9 days of hospitalization, we found that 37% of patients had positive FM at least once during hospitalization and these patients had increased in-hospital mortality (p = 0.001). Thus, we used non-adjusted Kaplan–Meier curves for in-hospital mortality according to FM positivity during hospitalization and we observed a statistically significant difference for in-hospital mortality (hazard ratio = 1.48, 95% CI: 1.25–1.76, p < 0.001). However, we compared the AUC of FM positivity associated with a ratio of D-dimer >70% and found that this combined receiver operating characteristic (ROC) curve was superior to the FM positivity ROC curve alone.ConclusionMonitoring of FM positivity in hospitalized patients with COVID-19 could be a reliable and helpful tool to predict the worsening condition and mortality of COVID-19.

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Preanalytical Conditions Impact Fibrin Monomers but Not D‐Dimer: A Study With Rigorous Comparisons of a Broad Range of Simulated Conditions

Bouarroudj,

Hardy,

Lecompte

et al. 2024

Int J Lab Hematology

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Serial fibrin monomer and D-dimer plasma levels measurements can capture thrombotic complications in critically ill COVID-19 patients: A prospective observational study

Cited by 3 publications

References 26 publications

COVID-19 and the Concept of Thrombo-Inflammation: Review of the Relationship between Immune Response, Endothelium and Coagulation

COVID-19 and the Concept of Thrombo-Inflammation: Review of the Relationship between Immune Response, Endothelium and Coagulation

Fibrin monomers evaluation during hospitalization for COVID-19 is a predictive marker of in-hospital mortality

Preanalytical Conditions Impact Fibrin Monomers but Not D‐Dimer: A Study With Rigorous Comparisons of a Broad Range of Simulated Conditions

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