Upper gastrointestinal bleeding can manifest as hematemesis (bright red vomiting or coffee ground emesis). Upper gastrointestinal bleeding (UGIB) is defined as blood loss from a gastrointestinal source above the ligament of Treitz. Cases of gastrointestinal bleeding account for 150 inpatients per 100,000 population each year, with upper gastrointestinal bleeding 1.5-2 times more common than lower gastrointestinal bleeding. The incidence is higher in elderly patients and patients whom taking multiple medications or multi-pharmacy. If not treated properly, gastrointestinal bleeding can cause death. Idiopathic thrombocytopenic Purpura (ITP) is an autoimmune disease characterized by low platelet counts, purpura, and hemorrhagic episodes caused by antiplatelet autoantibodies. ITP cases most often occur in children with 85% not requiring treatment and young adults aged 20-50 years who are healthy within a few weeks of being infected with the virus. The problem is described using a descriptive case study method starting from history taking, physical examination, evaluation, diagnosis to the intervention management given to patients qualitatively. We reported a-70-year-old patient with Hematemesis and Melena accompanied by Idiopathic Thrombocytopenia Purpura. Then the patient was given treatment SF 2x1 tablet, Mersibion 2x1 tablet, Metformin 1x 500mg tablet. Parenteral treatment with Vit K 3x10, Omeprazole 1x40 mg injection, Ondansetron 2x8mg injection, Transamin 3x500 injectionz, NS 0.9% 500cc 6 hours/kolf.