Serial Magnetic Resonance Imaging to Identify Early Stages of Anthracycline-Induced Cardiotoxicity

Galán‐Arriola, Carlos; Lobo, Manuel; Vílchez-Tschischke, Jean Paul; López, Gonzalo Javier; Molina-Iracheta, Antonio; Pérez-Martínez, Claudia; Agüero, Jaume; Fernández‐Jiménez, Rodrigo; Martín-García, Ana; Oliver, Eduardo; Villena-Gutiérrez, Rocío; Pizarro, Gonzalo; Sánchez, Pedro L.; Fuster, Valentín; Sánchez‐González, Javier; Ibáñez, Borja

doi:10.1016/j.jacc.2018.11.046

Cited by 200 publications

(181 citation statements)

References 37 publications

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“…[75][76][77] Recent data suggest that novel CMR indices may be potentially the earliest markers of AC-induced damage: an intracellular water life time ic , related to the size of cardiomyocyte, 47 and a prolongation of T 2 relaxation time, correlated with intra-cardiomyocyte oedema. 78 Cardiac magnetic resonance is particularly important for cancer patients receiving ICI with new cardiac symptoms, arrhythmias or cardiac troponin elevation when ICI-mediated myocarditis is suspected. 79 Additionally, CMR is an excellent test for the comprehensive evaluation of pericardial diseases, cardiac masses, infiltrative (amyloidosis) as well as storage diseases.…”

Section: Echocardiography During Immune Checkpoint Inhibitor Treatmentmentioning

confidence: 99%

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Čelutkienė

Pudil

López‐Fernández

et al. 2020

European J of Heart Fail

276

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Cardiovascular (CV) imaging is an important tool in baseline risk assessment and detection of CV disease in oncology patients receiving cardiotoxic cancer therapies. This position statement examines the role of echocardiography, cardiac magnetic resonance, nuclear cardiac imaging and computed tomography in the management of cancer patients. The Imaging and Cardio-Oncology Study Groups of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) in collaboration with the European Association of Cardiovascular Imaging (EACVI) and the Cardio-Oncology Council of the ESC have evaluated the current evidence for the value of modern CV imaging in the cardio-oncology field. The most relevant echocardiographic parameters, including global longitudinal strain and three-dimensional ejection fraction, are proposed. The protocol for baseline pre-treatment evaluation and specific surveillance algorithms or pathways for anthracycline chemotherapy, HER2-targeted therapies such as trastuzumab, vascular endothelial growth factor tyrosine kinase inhibitors, BCr-Abl tyrosine kinase inhibitors, proteasome inhibitors and immune checkpoint inhibitors are presented. The indications for CV imaging after completion of oncology treatment are considered. The typical consequences of radiation therapy and the possibility of their identification in the long term are also summarized. Special populations are discussed including female survivors planning pregnancy, patients with carcinoid disease, patients with cardiac tumours and patients with right heart failure. Future directions and ongoing CV imaging research in cardio-oncology are discussed.

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Section: Echocardiography During Immune Checkpoint Inhibitor Treatmentmentioning

confidence: 99%

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Čelutkienė

Pudil

López‐Fernández

et al. 2020

European J of Heart Fail

276

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“…Given the recent development of deep brain stimulation, Parkinson's, Alzheimer's, and stroke models in the pig [13][14][15] , the tools presented here have the potential to permit ndings from these models to inform the design of novel therapeutic strategies in the treatment of neurological disease. Furthermore the open distribution of our translational imaging and analysis platform will further allow for the neurological phenotyping of disease progression in the cardiac, renal, gastric, hepatic, and vascular disease models already available in the pig [4][5][6][7][8][9][10] . Doing so may provide insight into the adaptive responses and structural reorganization of the cortex initiated by disease in the body and could facilitate the combination of longitudinal studies in pigs and crosssectional studies in clinical subjects.…”

Section: Discussionmentioning

confidence: 99%

“…The pig diverged from humans approximately 80 million years ago, but convergent evolution and an omnivore diet have led to a viscera strikingly similar to that of the human 2,3 . The pig can be genetically modi ed and is already used as a model for cardiac, renal, gastric, hepatic, dermal, vascular, craniofacial surgery, making it an ideal model to investigate the neural correlates of disease in the body [4][5][6][7][8][9][10] . Advances in high resolution non-invasive magnetic resonance imaging (MRI) and surgical methods have led to the development of stroke, deep brain stimulation, Parkinson's and Alzheimer's Disease, traumatic brain injury, and epilepsy models renewing interest in the pig as a neurological model of disease 1,[11][12][13][14][15][16] .…”

Section: Introductionmentioning

confidence: 99%

A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

Mars

et al. 2020

Preprint

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The characterization and definition of homology in the cerebral cortex needed for a species to be adopted as a translational model in neuroscience is a unique challenge given the diverse array of cortical morphology present in the mammalian lineage. Using the domestic pig as an example, we provide a roadmap of how leveraging Magnetic Resonance Imaging of the brain and data-driven tractography can overcome these obstacles and facilitate cortical alignment between distantly related species. In doing so, we created a full platform of neuroimaging tools to be used in the pig, including volumetric and surface templates, a structural white matter atlas, and the establishment of a common connectivity space to facilitate pig-human cortical alignment. Releasing our data and code and our pig-human cortical alignment, we permit researchers already working with the pig to accentuate the clinical relevance and translational capacity of their work. By sharing the intermediate outputs and scripts used to construct our pig-human cortical alignment, we also provide a roadmap to expand the current repertoire of animal models used in neuroscience.

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“…Additionally, novel CMR multi-parametric techniques, such as T1 and T2 mapping, allow accurate characterization of myocardial tissue. With these techniques, early signs of chemotherapy-induced cardiomyopathy, such as myocardial edema and diffuse fibrosis, can be detected [20,21].…”

Section: Discussionmentioning

confidence: 99%

Healthcare utilization and hospital variation in cardiac surveillance during breast cancer treatment: a nationwide prospective study in 5000 Dutch breast cancer patients

et al. 2020

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Background: Various breast cancer (BC) treatments, such as chemotherapy and targeted therapies, increase cardiotoxicity-risk and lead to premature ischemic heart disease and heart failure among survivors. Reducing this adverse risk through early recognition and (preventive) treatment is therefore important. Conversely, we feel that screening for cardiotoxicity is currently insufficiently standardized in daily practice. A fundamental first step in identifying areas of improvement is providing an overview of current practice. Objective: This study aims to describe current cardiac surveillance for women with BC during and after cardiotoxic cancer treatment, using routinely collected hospital data in the Netherlands. The study also describes hospital variation in cardiac surveillance. Methods: This observational study was performed on claims data provided by Statistics Netherlands. From the data, newly diagnosed BC patients in 2013 (N = 16,040) were selected and followed up until 2015. Healthcare utilization analyses were performed for all cardiac and oncologic healthcare activities but with a specific focus on cardiac surveillance healthcare activities. In addition, differences between types and individual hospitals were evaluated. Results: Almost one third of all BC patients received high risk cardiotoxic treatments (N = 5157), but cardiac surveillance was rarely performed. Cardiac care provided to patients mainly consisted of ECGs (52.0%) and MUGA scans (26.5%). Cardiac MRI was performed in 0.7% of the patients, echocardiography in 17.7%, and measurement of Troponin and NT-proBNP in 5.1 and 5.8%, respectively. Moreover, we observed a substantial variation in cardiac surveillance between different hospital types and between individual hospitals. Conclusion: This study shows that women treated for BC with cardiotoxic treatments do not receive recommended cardiac surveillance. Standardized approaches in clinical care are lacking, resulting in low rates of diagnostic testing and a substantial variation in surveillance between hospitals. A structured approach and increased interprofessional collaboration could lead to tailored cardiac surveillance for early detection of cardiotoxicity and therefore start of treatment.

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Serial Magnetic Resonance Imaging to Identify Early Stages of Anthracycline-Induced Cardiotoxicity

Cited by 200 publications

References 37 publications

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

Role of cardiovascular imaging in cancer patients receiving cardiotoxic therapies: a position statement on behalf of the Heart Failure Association (HFA), the European Association of Cardiovascular Imaging (EACVI) and the Cardio‐Oncology Council of the European Society of Cardiology (ESC)

A Pig White Matter Atlas and Common Connectivity Space Provide a Roadmap for the Introduction of a New Animal Model in Translational Neuroscience

Healthcare utilization and hospital variation in cardiac surveillance during breast cancer treatment: a nationwide prospective study in 5000 Dutch breast cancer patients

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