Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy

Kooij, Britt J.M. van; Handel, M; Nievelstein, Rutger A.J.; Groenendaal, Floris; Jongmans, Marian J.; Vries, Linda S. de

doi:10.1016/j.jpeds.2010.02.016

Cited by 114 publications

(121 citation statements)

References 33 publications

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“…Previous long-term follow-up studies suggest that survivors of neonatal encephalopathy without major disability typically have an increased risk of subtle neurological disabilities when they are assessed at school age. In contrast, consistent with the present study, severe disability diagnosed early in life is persistent (7)(8)(9)(10), and the severity of disability appears to be proportional to the severity of neural injury in the neonatal period and in childhood (11,12). For example, in one cohort of 53 children born at term with encephalopathy, 36% had cerebral palsy; of the 34 remaining infants, at school age 8 (15%) had minor neurological dysfunction and/or perceptual-motor WeeFIM ratings as a function of outcome at 18 mo of age.…”

Section: Discussionsupporting

confidence: 90%

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

et al. 2011

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Section: Discussionsupporting

confidence: 90%

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

et al. 2011

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“…Insurance companies need to be asked to finance future follow-up to provide more detailed information on the effects of this treatment. This is relevant, since more subtle deviations may become apparent at later ages, especially in neonates with less severe perinatal asphyxia [25]. …”

Section: Discussionmentioning

confidence: 99%

Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders

et al. 2013

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Background: Therapeutic hypothermia was introduced in the Netherlands and Flanders, Belgium, in 2008. Since then, an increasing number of patients has been treated - up to 166 in 2010. Complications and outcome were registered in an online database. Objectives: The aim of this study was to analyse complications and outcome after implementation. Methods: Data were retrieved from an online database to which all centres had contributed. Results: In 3 years, 332 patients were treated. Excluding 24 patients with congenital abnormalities or metabolic disorders, mortality was 31.8%. Of the 210 survivors without congenital malformations, 21 had cerebral palsy, another 19 a developmental delay of more than 3 months at the age of at least 24 months, and 2 had severe hearing loss. The total adverse outcome, combining death and adverse neurodevelopment, in 308 patients without congenital malformations is 45.5%, which is similar to that of the large trials. Conclusions: The introduction of therapeutic hypothermia for neonates with perinatal asphyxia in the Netherlands and Flanders has been rapid and successful, with results similar to findings in the randomised controlled trials.

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“…The combination of partial and total asphyxia is associated with more ominous outcomes than other patterns of injury. Bilateral involvement and a higher intensity of the echogenicity predict poorer neurodevelopmental and mortality outcomes in the short term, as well as worse cognitive and motor outcomes in the long term, than less extensive injuries [4,5].…”

Section: Concurrent Partial and Near Total Asphyxiamentioning

confidence: 99%

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

et al. 2018

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Hypoxic-ischemic injury (HII) of the neonatal brain and resulting clinical hypoxic-ischemic encephalopathy remains a significant cause of morbidity and mortality in the neonatal population. Ultrasound (US) has emerged as a powerful screening tool for evaluation of a neonate with suspected HII. The pattern of injury on brain imaging has crucial implications in therapies and predicted neurodevelopmental outcomes. US has become increasingly effective at determining the pattern, timing, and extent of injury in HII as well as differentiating these findings from a host of diagnoses that can result in a similarly appearing clinical picture. Repeated US studies over a patient’s course can define the evolution of findings from the acute through chronic phase in addition to identifying any complications of therapy. US also has the added benefits of easy portability, no need for patient sedation, and a relatively low cost when compared to other imaging modalities like magnetic resonance imaging (MRI). It is crucial that clinicians understand the full capabilities of advanced US in identifying an underlying diagnosis, directing appropriate therapy, monitoring disease progress, and finally in predicting outcomes, thus improving the care of neonates with encephalopathy. The following article demonstrates the breadth of uses for US in the full-term neonate with encephalopathy, its limitations, the patterns of injury seen, and their evolution over time. We will also briefly review several clinical mimickers of HII for comparison.

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Serial MRI and Neurodevelopmental Outcome in 9- to 10-Year-Old Children with Neonatal Encephalopathy

Cited by 114 publications

References 33 publications

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

Seven- to eight-year follow-up of the CoolCap trial of head cooling for neonatal encephalopathy

Introduction of Hypothermia for Neonates with Perinatal Asphyxia in the Netherlands and Flanders

Head Ultrasound in Neonatal Hypoxic-Ischemic Injury and Its Mimickers for Clinicians: A Review of the Patterns of Injury and the Evolution of Findings Over Time

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