Serial multidetector computed tomography assessment of left ventricular reverse remodeling, mass, and regional wall stress after restrictive mitral annuloplasty in dilated cardiomyopathy

Shudo, Yasuhiro; Taniguchi, Koichi; Takeda, Koji; Sakaguchi, Taichi; Funatsu, Toshihiro; Kondoh, Haruhiko; Sawa, Yoshiki

doi:10.1016/j.jtcvs.2011.11.013

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…13 It provides excellent temporal and spatial resolution, it is very accurate, and it facilitates reproducible quantitative measurements of cardiac structure and function. 20 In our study, cardiac MRI illustrated post infarction, eccentric adverse ventricular remodeling in both cell sheet-treated and untreated negative control groups. However, EPC-SMC cell sheet transplantation significantly enhanced ventricular function and attenuated ventricular remodeling compared with that of untreated controls.…”

Section: Discussionsupporting

confidence: 50%

Layered smooth muscle cell–endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Shudo

Goldstone

Cohen

et al. 2017

The Journal of Thoracic and Cardiovascular Surgery

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Objective The angiogenic potential of endothelial progenitor cells (EPCs) may be limited by the absence of their natural biologic foundation, namely smooth muscle pericytes. We hypothesized that joint delivery of EPCs and smooth muscle cells (SMCs) in a novel, totally bone marrow-derived cell sheet will mimic the native architecture of a mature blood vessel and act as an angiogenic construct to limit post infarction ventricular remodeling. Methods Primary EPCs and mesenchymal stem cells (MSCs) were isolated from bone marrow of Wistar rats. MSCs were transdifferentiated into SMCs by culture on fibronectin-coated culture dishes. Confluent SMCs topped with confluent EPCs were detached from an Upcell dish to create a SMC-EPC bi-level cell sheet. A rodent model of ischemic cardiomyopathy was then created by ligating the left anterior descending artery. Rats were randomized into three groups: cell sheet transplantation (n=9), no treatment (n=12), or sham surgery control (n=7). Results Four weeks post infarction mature vessel density tended to increase in cell sheet-treated animals compared with controls. Cell sheet therapy significantly attenuated the extent of cardiac fibrosis compared with that of the untreated group (untreated vs. cell sheet, 198 degrees (IQR, 151 degrees – 246 degrees) vs. 103 degrees (IQR, 92 degrees – 113 degrees), p=0.04). Furthermore, EPC-SMC cell sheet transplantation attenuated myocardial dysfunction, as evidenced by an increase in LV ejection fraction (untreated vs. cell sheet vs sham, 33.5% (IQR, 27.8%–35.7%) vs. 45.9% (IQR, 43.6%–48.4%) vs. 59.3% (IQR, 58.8%–63.5%), p=0.001) and decreases in LV dimensions. Conclusions The bone marrow-derived, spatially arranged SMC-EPC bi-level cell sheet is a novel, multi-lineage cellular therapy obtained from a translationally practical source. Interactions between SMCs and EPCs augment mature neovascularization, limit adverse remodeling, and improve ventricular function after myocardial infarction.

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Section: Discussionsupporting

confidence: 50%

Layered smooth muscle cell–endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Shudo

Goldstone

Cohen

et al. 2017

The Journal of Thoracic and Cardiovascular Surgery

Self Cite

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“…LV remodeling is usually assessed using echocardiography 10,11,12 but has also been assessed using single-photon computed tomography (SPECT) and CMR 20 . Computed tomography (CT) is another modality to assess serial LV volumes 21 . Although assessment of LV volumes by SPECT and CT are highly reproducible, they utilize ionized radiation.…”

Section: Discussionmentioning

confidence: 99%

Redefining Adverse and Reverse Left Ventricular Remodeling by Cardiovascular Magnetic Resonance Following ST-Segment–Elevation Myocardial Infarction and Their Implications on Long-Term Prognosis

Bulluck

Carberry

Carrick

et al. 2020

Circ: Cardiovascular Imaging

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Background: Cut-off values for change in left ventricular end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) by cardiovascular magnetic resonance (CMR) following ST-segment elevation myocardial infarction (STEMI) have recently been proposed and 4 patterns of LV remodeling were described. We aimed to assess their long-term prognostic significance.Methods: A prospective cohort of unselected STEMI patients with paired acute and 6-month CMR, with the 5-year composite endpoint of all-cause death and hospitalization for heart failure was included. The prognosis of the following groups [Group 1: reverse LV remodeling (≥12% decrease in LVESV); Group 2: no LV remodeling (changes in LVEDV and LVESV <12%); Group 3: adverse LV remodeling with compensation (≥12% increase in LVEDV only); and Group 4: adverse LV remodeling (≥12% increase in both LVESV and LVEDV)] was compared.Results: 285 patients were included with a median follow-up was 5.8 years. The composite endpoint occurred in 9.5% in Group 1, 12.3% in Group 2, 7.1% in Group 3 and 24.2% in Group 4. Group 4 had significantly higher cumulative event rates of the composite endpoint (log-rank test p=0.03) with the other 3 groups showing similar cumulative event rates (logrank test p=0.51). Cox proportional hazard for Group 2 [HR 1.3 (95% CI 0.6-3.1), p=0.53] and Group 3 [HR 0.6 (95% CI 0.2-2.3), p=0.49] were not significantly different but was significantly higher in Group 4 [HR 3.0 (95% CI (1.2-7.1), p=0.015] when compared to Group 1.

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“…They found that 64-slice CT more accurately evaluated left ventricle function than ventriculography or echocardiography. Other researchers also showed that CT was useful in evaluating the function of the left ventricle in patients with cardiomyopathy or valvular disease (206, 207, 208), and reported on the feasibility using CT in the evaluation of the diastolic function of the left ventricle (209). However, the use of CT is restricted by radiation exposure and the use of contrast agents.…”

Section: Prefacementioning

confidence: 99%

Korean Guidelines for the Appropriate Use of Cardiac CT

et al. 2015

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The development of cardiac CT has provided a non-invasive alternative to echocardiography, exercise electrocardiogram, and invasive angiography and cardiac CT continues to develop at an exponential speed even now. The appropriate use of cardiac CT may lead to improvements in the medical performances of physicians and can reduce medical costs which eventually contribute to better public health. However, until now, there has been no guideline regarding the appropriate use of cardiac CT in Korea. We intend to provide guidelines for the appropriate use of cardiac CT in heart diseases based on scientific data. The purpose of this guideline is to assist clinicians and other health professionals in the use of cardiac CT for diagnosis and treatment of heart diseases, especially in patients at high risk or suspected of heart disease.

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Serial multidetector computed tomography assessment of left ventricular reverse remodeling, mass, and regional wall stress after restrictive mitral annuloplasty in dilated cardiomyopathy

Cited by 5 publications

References 12 publications

Layered smooth muscle cell–endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Layered smooth muscle cell–endothelial progenitor cell sheets derived from the bone marrow augment postinfarction ventricular function

Redefining Adverse and Reverse Left Ventricular Remodeling by Cardiovascular Magnetic Resonance Following ST-Segment–Elevation Myocardial Infarction and Their Implications on Long-Term Prognosis

Korean Guidelines for the Appropriate Use of Cardiac CT

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