Serial Neck Ultrasonographic Evaluation of Changes in Papillary Thyroid Carcinoma During Pregnancy

OhHye-Seon,; Gu, KimWon; ParkSuyeon,; KimMijin,; KwonHyemi,; Jeon, Min Ji; Hyun, LeeJeong; Hwan, BaekJung; Eun, SongDong; Yong, KimTae; Kee, ShongYoung; Bae, KimWon

doi:10.1089/thy.2016.0618

Cited by 31 publications

(13 citation statements)

References 22 publications

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“…However, a long-term follow-up study involving the entire AS cohort from Kuma Hospital did not find higher rates of disease progression during pregnancy: tumor enlargement occurred in only four out of 51 patients during pregnancy [ 23 ]. Our group also examined the clinical outcomes of PTC patients who had delayed surgery due to pregnancy, and there was no clinically significant disease progression during observation [ 24 ].…”

Section: Optimal Indications For Asmentioning

confidence: 99%

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Jeon

Kim

et al. 2021

Endocrinol Metab

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Active surveillance (AS) for low-risk papillary thyroid microcarcinoma (PTMC) has been accepted worldwide as safe and effective. Despite the growing acceptance of AS in the management of low-risk PTMCs, there are barriers to AS in real clinical settings, and it is important to understand and establish appropriate AS protocol from initial evaluation to follow-up. PTMC management strategies should be decided upon after careful consideration of patient and tumor characteristics by a multidisciplinary team of thyroid cancer specialists. Patients should understand the risks and benefits of AS, participate in decision-making and follow structured monitoring strategies. In this review, we discuss clinical outcomes of AS from previous studies, optimal indications and follow-up strategies for AS, and unresolved questions about AS.

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Section: Optimal Indications For Asmentioning

confidence: 99%

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Jeon

Kim

et al. 2021

Endocrinol Metab

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“…In a retrospective review of 235 women who had a term pregnancy after initial treatment for differentiated thyroid cancer (1997-2015), Rakhlin et al reported that the majority of thyroid cancer patients who had an excellent, indeterminate, or biochemical incomplete response to treatment prior to pregnancy did not demonstrate progression or recurrence after delivery (13). In a recent study of 19 patients who were diagnosed with WDTC just before or during early pregnancy, the primary tumor size remained stable in most patients, and no patients developed cervical lymph node or distant metastasis during follow-up (14). Finally, in a retrospective casecontrol review, Yasmeen et al demonstrated that tumor characteristics, stage at diagnosis, and overall survival were similar between women with pregnancy-associated thyroid cancer and non-pregnant controls (15).…”

Section: Discussionmentioning

confidence: 99%

Recent Pregnancy Is Not Associated with High-Risk Pathological Features of Well-Differentiated Thyroid Cancer

Chen

Livhits

et al. 2018

Thyroid

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“…Neck ultrasound (US) examinations were performed using either an iU22 unit (Philips Healthcare, Bothell, WA, USA) or an EUB-7500 unit (Hitachi Medical Systems, Tokyo, Japan) equipped with a linear high-frequency probe (5 to 14 MHz), as previously reported [ 24 ]. The scanning protocol included both transverse and longitudinal real-time imaging.…”

Section: Methodsmentioning

confidence: 99%

Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAF^V600EMutation in Thyroid Neoplasm

Kwon

Park

et al. 2018

Endocrinol Metab

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BackgroundThe BRAFV600E mutation is the most common genetic alteration identified in papillary thyroid carcinoma (PTC). Because of its costs effectiveness and sensitivity, direct Sanger sequencing has several limitations. The aim of this study was to evaluate the efficiency of immunohistochemistry (IHC) as an alternative method to detect the BRAFV600E mutation in preoperative and postoperative tissue samples.MethodsWe evaluated 71 patients who underwent thyroid surgery with the result of direct sequencing of the BRAFV600E mutation. IHC staining of the BRAFV600E mutation was performed in 49 preoperative and 23 postoperative thyroid specimens.ResultsSixty-two patients (87.3%) had PTC, and of these, BRAFV600E was confirmed by direct sequencing in 57 patients (91.9%). In 23 postoperative tissue samples, the BRAFV600E mutation was detected in 16 samples (70%) by direct sequencing and 18 samples (78%) by IHC. In 24 fine needle aspiration (FNA) samples, BRAFV600E was detected in 18 samples (75%) by direct sequencing and 16 samples (67%) by IHC. In 25 core needle biopsy (CNB) samples, the BRAFV600E mutation was detected in 15 samples (60%) by direct sequencing and 16 samples (64%) by IHC. The sensitivity and specificity of IHC for detecting the BRAFV600E mutation were 77.8% and 66.7% in FNA samples and 99.3% and 80.0% in CNB samples.ConclusionIHC could be an alternative method to direct Sanger sequencing for BRAFV600E mutation detection both in postoperative and preoperative samples. However, application of IHC to detect the BRAFV600E mutation in FNA samples is of limited value compared with direct sequencing.

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Serial Neck Ultrasonographic Evaluation of Changes in Papillary Thyroid Carcinoma During Pregnancy

Abstract: No clinically relevant changes associated with a progression of PTC were observed during pregnancy. Delayed thyroid surgery with active surveillance can be an appropriate approach for pregnant patients with PTC.

Cited by 31 publications

References 22 publications

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Recent Pregnancy Is Not Associated with High-Risk Pathological Features of Well-Differentiated Thyroid Cancer

Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAF^V600EMutation in Thyroid Neoplasm

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Serial Neck Ultrasonographic Evaluation of Changes in Papillary Thyroid Carcinoma During Pregnancy

Abstract: No clinically relevant changes associated with a progression of PTC were observed during pregnancy. Delayed thyroid surgery with active surveillance can be an appropriate approach for pregnant patients with PTC.

Cited by 31 publications

References 22 publications

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Active Surveillance as an Effective Management Option for Low-Risk Papillary Thyroid Microcarcinoma

Recent Pregnancy Is Not Associated with High-Risk Pathological Features of Well-Differentiated Thyroid Cancer

Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAFV600EMutation in Thyroid Neoplasm

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Comparison of Immunohistochemistry and Direct Sanger Sequencing for Detection of theBRAF^V600EMutation in Thyroid Neoplasm