Serial pulmonary function tests in progressive systemic sclerosis.

Bagg, L R; Hughes, David T.

doi:10.1136/thx.34.2.224

Cited by 53 publications

(17 citation statements)

References 17 publications

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“…Moreover, among SSc patients, a negative correlation between TLCO/V A ratio and IL-4 levels (Spearman's coeffi cient = -0.46; p = 0.049) was evident. These fi ndings are coherent with the patho-physiology of the disease as regards the evolution of lung interstitial disease, where the TLCO parameter impairment appears as a validated indicator [29,30].…”

Section: Discussionsupporting

confidence: 74%

Cytokine concentrations in exhaled breath condensates in systemic sclerosis

et al. 2008

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Section: Discussionsupporting

confidence: 74%

Cytokine concentrations in exhaled breath condensates in systemic sclerosis

et al. 2008

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“…In all cases there was perfect agreement between the two observers. Interstitial disease was located either in both lungs (patients 1, 4,5,6,9), predominantly in the upper lobes (patients 10 and 12), or in one upper lobe (patients 2 and 8). Patient 7 had bilateral axillary pleural thickening and centrilobular emphysema.…”

Section: Resultsmentioning

confidence: 99%

Imaging of pulmonary disease in scleroderma with J001X scintigraphy.

Diot

Lemarié

et al. 1994

Thorax

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Background -JOOIX is an acylated polygalactoside isolated from the membrane of Klebsiella and able to interact with macrophages, mainly in their activated state. The aim of the present study was to determine the ability of 99m-labelled technetium ("mTc)-JOOlX scintigraphy to image pulmonary disease, defined by high resolution computed tomographic scanning and pulmonary function tests, in patients suffering from scleroderma. Methods -Patients were considered to have pulmonary disease when they had at least two positive signs on high resolution computed tomography, or a decrease in lung volume and single breath carbon monoxide transfer, or both, with no disease process other than scleroderma in their medical history. Positive JOO1X scintigraphic imaging was defined by symmetrical bilateral pulmonary fixation three and five hours after inhalation of -mTc-JOO1X. JOOlX scintigraphic results were compared with disease activity as indicated by bronchoalveolar lavage (BAL) fluid lymphocytosis. Results -Seventeen patients were studied, in 12 ofwhom JOO1X scintigraphy was positive. There was no correlation between BAL lymphocytosis and JOO1X scintigraphic findings, nor between BAL and pulmonary scleroderma. This was not surprising because of the high specificity of macrophage targeting by JOO1X. Conclusions -Follow up of a larger population over a longer period is needed to establish whether there is a prognostic value for positive JOOlX scintigraphic findings in scleroderma.

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“…Small airway involvement in connective tissue disease is recognized especially in patients with RA or PSS, due to abnormalities in maximal midexpiratory flow rate (Collins et al 1976), flow volume curves with He-02 (Mountz et al 1984) or RV% (Guttadauria et al 1977;Bagg and Hughes 1979). Moreover, Hills et al (1979) indicated that if frequency dependence of dynamic compliance not accompanied by other abnormalities is found in RA patients, it may serve as a sign to detect early lung disease.…”

Section: Resultsmentioning

confidence: 99%

“…Pulmonary function tests in these patients, especially in those with PSS and RA, often show restrictive and/or obstructive damage and, recently, small airway impairments (Collins et al 1976; Guttadauria et al 1977; Bagg and Hughes 1979;Hills et al 1979; Hunninghake and Fauci 1979; Begin et al 1982; Mountz et al 1984). Moreover, it has been reported that diffusing capacity is frequently decreased in MCTD patients (Sharp 1974(Sharp -1975Singsen et al 1977; Wiener-Kronish et al 1981; Sullivan et al 1984; Takasaki et al 1984; Derderian et al 1985; Prakash et al 1985), but there are few studies concerning the small airways.…”

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confidence: 99%

Small Airway Involvement in Mixed Connective Tissue Disease.

Izumiyama

Hida

Ichinose

et al. 1993

Tohoku J. Exp. Med.

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We studied pulmonary functions in 17 female patients with mixed connective tissue disease (MCTD) to detect early pulmonary involvement in this disease; in 8 of the 17 patients followup studies were also performed at 1.2-to 5.9-year intervals. In the first pulmonary function tests, decreases in vital capacity (VC) and diffusing capacity (DL~o) were observed in 6 (35%) and 8 (47%) patients, respectively. The ratio of forced expiratory volume in one second to VC was normal in all the patients, but pulmonary resistance and static compliance were abnormal in 6 (35%) and 10 (59%) patients, respectively. However, frequency dependence of dynamic compliance was found in all 16 patients tested. Moreover, 4 (24%) of the 17 patients had normal DL~o and DL~o-to-alveolar volume ratio (DLCO/VA). Reductions in DL~o and DLCo/VA were significantly correlated with the disease duration. These results suggest that small airway obstruction is an early and frequent indication of functional pulmonary impairment, and that impairment of alveolar gas exchange is progressive in patients with MCTD.connective tissue disease; small airways; frequency dependence of dynamic compliance; diffusing capacity

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Serial pulmonary function tests in progressive systemic sclerosis.

Cited by 53 publications

References 17 publications

Cytokine concentrations in exhaled breath condensates in systemic sclerosis

Cytokine concentrations in exhaled breath condensates in systemic sclerosis

Imaging of pulmonary disease in scleroderma with J001X scintigraphy.

Small Airway Involvement in Mixed Connective Tissue Disease.

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