Serine protease inhibitors decrease metastasis in prostate, breast, and ovarian cancers
Amiram Sananes,
Itay Cohen,
Irit Allon
et al.
Abstract:Targeted therapies for prostate, breast and ovarian cancers are based on their activity against primary tumors rather than their anti‐metastatic activity. Consequently, there is an urgent need for new agents targeting the metastatic process. Emerging evidence correlates in vitro and in vivo cancer invasion and metastasis with increased activity of the proteases mesotrypsin (prostate and breast cancer) and kallikrein 6 (KLK6; ovarian cancer). Thus, mesotrypsin and KLK6 are attractive putative targets for therap… Show more
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