2024
DOI: 10.18632/aging.205841
|View full text |Cite
|
Sign up to set email alerts
|

Serine racemase expression profile in the prefrontal cortex and hippocampal subregions during aging in male and female rats

Linda Bean,
Prodip K. Bose,
Asha Rani
et al.

Abstract: Aging is associated with a decrease in N-methyl-D-aspartate (NMDA) receptor function, which is critical for maintaining synaptic plasticity, learning, and memory. Activation of the NMDA receptor requires binding of the neurotransmitter glutamate and also the presence of co-agonist D-serine at the glycine site. The enzymatic conversion of L-serine to D-serine is facilitated by the enzyme serine racemase (SR). Subsequently, SR plays a pivotal role in regulating NMDA receptor activity, thereby impacting synaptic … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 63 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?