Serine Supplementation in the Diets of Late Gestating and Lactating Sows Improves Selenium Nutritional Status in Sows and Their Offspring

Zhou, Lamei; Feng, Yanzhong; Liu, Yonghui; He, Liuqin; Zhou, Xin; Yin, Yulong

doi:10.1007/s12011-021-02661-x

Cited by 10 publications

(5 citation statements)

References 19 publications

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“…Importantly, serine improves glucose tolerance and insulin sensitivity in high-fat diet-induced mice ( Zhou et al, 2018 ). Interestingly, recent studies found that dietary serine had beneficial effects on nutritional status of selenium and selenoprotein activity ( Long et al, 2021 ; He Y. et al, 2022 ; Zhou L. et al, 2022 ). Moreover, the synergistic effects of serine with selenium on the alleviation of oxidative stress were confirmed in vivo and in vitro ( Wang et al, 2016 ; He L. et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Cui

Chen²,

Yang³

2022

Front. Microbiol.

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Either selenium or serine could modulate glucose homeostasis, however, whether there are synergistic effects of selenium with serine on diabetes remains to be unknown. In the present study, eight male db/m mice were used as a control, and 24 male diabetic db/db mice were either orally gavaged with PBS, or with selenomethionine alone, or with both selenomethionine and serine, to investigate the effects of selenomethionine and serine on body weight and glucose level. Furthermore, intestinal microbiota composition was analyzed and fecal microbiota transplantation (FMT) was performed to explore whether microbes mediate the beneficial effects of selenomethionine and serine. The results showed that administration of selenomethionine decreased body weight, adipose tissue weight and serum glucose level in db/db diabetic mice. Importantly, administration of selenomethionine in combination with serine exerted better effects than selenomethionine alone did. Furthermore, a combined administration of selenomethionine and serine restored the microbial composition in diabetic mice. Corynebacterium glutamicum, Bifidobacterium pseudolongum, and Aerococcus urinaeequi were significantly decreased, whereas Lactobacillus murinus was increased in mice in the selenomethionine group and selenomethionine in combination with serine group, when compared with those in the db/db group. FMT decreased body weight and glucose level in db/db mice, further indicating that microbes play critical roles in the beneficial effects of selenomethionine and serine. Thus, we concluded that administration of selenomethionine in combination with serine benefits diabetes via gut microbes. Our results suggested that the synergic application of selenomethionine and serine could be potentially used for the treatment of diabetes.

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Section: Introductionmentioning

confidence: 99%

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Cui

Chen²,

Yang³

2022

Front. Microbiol.

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“…In Experiment 1, plasma serine concentration of male rats increased with increasing serine concentration in a serine deficient diet. Dietary serine concentration was positively associated with plasma selenoprotein including selenoprotein P (SELENOP) and GPx3 concentration ( 4 ). This may be due to the fact that serine plays a pivotal role in the synthesis of selenocysteine ( Figure 10 ), and exogenous serine can affect the synthesis of selenoproteins in the body.…”

Section: Discussionmentioning

confidence: 99%

“…In vivo , serine supplementation greatly increased selenoproteintranscription and Se-containing enzyme (GPxs) activity in organs and tissues (such as skeletal, muscle and liver) of pigs ( 3 ). Also, the addition of serine in the maternal diet during the third trimester and subsequent lactation resulted in a greatly improved Se nutritional status in both sows and their offspring, in which may result in higher body weight offsprings ( 4 ). We have recently reported that the total amount of serine from dietary protein intake daily was associated with the nutritional status of Se in Chinese lactating women living in the traditional endemic areas of Keshan diseases ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of insufficient serine on health and selenoprotein expression in rats and their offspring

Liu

Wang

et al. 2022

Front. Nutr.

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ObjectiveTo observe the impact of insufficient exogenous and/or endogenous serine on selenoprotein expression and health of pregnant rats and their offspring.MethodExperiment 1 was conducted in male rats, in which the dose-dependent effects of serine on selenoprotein expression and thyroid hormones (T3, T4 and TSH) were investigated by feeding either a serine adequate diet (20C), serine-deprived diet (20CSD) or 20CSD with different serine levels (0.5, 1.0, and 2.0 times the amount of serine in 20C). In experiment 2, a PHGDH inhibitor was administrated to pregnant rats fed either 20C or 20CSD. Blood and organ tissues of pregnant rats and offspring were subjected to the analyses of thyroid hormone, serine and homocysteine and GPx3 and SELENOP in plasma and expression of GPx1 and DIO1, 2 in tissues respectively.ResultIn experiment 1, plasma SELENOP and GPx3 levels in adult male rats increased with the increasing dose of serine. Immunohistochemical results showed that GPx1 expression in liver and kidney of male rats also increased with increasing serine supplementation. Amongst all diet groups, only male rats fed 20CSD had significantly lower plasma TSH and T4 levels (P < 0.05). In experiment 2, GPx1 and DIO2 expression in the liver and kidney were suppressed in pregnant rats administered with a PHGDH compared to those who were not (P < 0.05). There were no significant differences in plasma T4 and T3 amongst all diet groups (P > 0.05). Also, offspring born to pregnant rats administered with a PHGDH inhibitor exhibited slower growth rates and hyperhomocysteinemia compared to offspring from mothers not administered with the inhibitor (P < 0.05). Conclusions: Insufficient exogenous serine through the diet decreased selenoprotein synthesis in adult male rats. However, this was not observed in pregnant rats, whereby exogenous or endogenous serine deficiency had no effect on the selenoprotein levels. A possible explanation is that dams may have an adaptive mechanism to limit maternal serine utilization and ensure adequate supply to the fetus.

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“…Histidine is a precursor of histamine, a biogenic amine which plays numerous physiological roles [33]. Serine has been found to be connected with selenium metabolism [34]. The connections between enzymes involved in amino acids (alanine and aspartate) metabolism and lithium exposure has also been stated [35].…”

Section: Discussionmentioning

confidence: 99%

“…However, in the light of the latest research, the issue of the mutual relationships between Se and amino acids becomes more complicated, because dietary serine supplementation to sows resulted in no change of serum selenium, while serum selenoprotein P was increased [34]. The small effect of selenium treatment on amino acids plasma profile seems to be of importance considering its application in agriculture, as well as the still growing interest in its supplementation both in pathological and physiological states.…”

Section: Discussionmentioning

confidence: 99%

The influence of lithium and/or selenium on plasma amino acids profile in rats

Kiełczykowska¹,

Musik²,

Luchowska-Kocot³

et al. 2021

Ann Agric Environ Med.

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Introduction. Selenium belongs to essential microelements and is used in agriculture. Lithium is used in medicine and the possibility of its exposure by environmental pollution has been reported. Both elements have been found to be connected with amino acids metabolism. Objective. The aim of the study was to compare the effect of lithium and selenium on plasma amino acids in rats, and to evaluate the influence of selenium in organisms exposed to lithium. Materials and method. The effect of selenium (0.5 mg/kg b.w., orally as Na 2 SeO 3 ) and/or lithium (2.7 mg/kg b.w., orally as Li 2 CO 3 ) given for 6 weeks on the plasma profile of selected amino acids in rats was studied. The concentrations of amino acids were determined using ion exchange chromatography with the aid of an amino acids analyzer AAA400. Results. A significant effect of lithium on plasma amino acids profile was found in rats, much greater than for selenium. Selenium treatment slightly increased Tau, Phe, Tyr, Ala, Trp, Ser and Gln, while Lys and Orn were enhanced in a significant way. In contrast, Li-treatment caused a well-marked increase in Phe, Orn, Ala, His, Trp, Asp and Gln, whereas all the others were only slightly increased. Co-treatment resulted in a significant increase in Orn and Trp, a slight enhancement of Phe, Lys and His, while the rest remained unchanged. Conclusions. A significant effect of lithium alone on plasma amino acids profile in animals was demonstrated, with a much less influence of selenium alone. Co-treatment generally resulted in a slight or no effect. The slight selenium influence seems important regarding its agricultural application and the growing interest in its supplementation. Results concerning lithium could contribute to the research regarding the mechanism of Li action.

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Serine Supplementation in the Diets of Late Gestating and Lactating Sows Improves Selenium Nutritional Status in Sows and Their Offspring

Cited by 10 publications

References 19 publications

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Administration of selenomethionine in combination with serine benefits diabetes via gut microbiota

Effects of insufficient serine on health and selenoprotein expression in rats and their offspring

The influence of lithium and/or selenium on plasma amino acids profile in rats

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