Serine/threonine protein kinase mediates rifampicin resistance in
Brucella melitensis
through interacting with ribosomal protein RpsD and affecting antioxidant capacity
Yaqin Yuan,
Wenqing Ning,
Junjie Chen
et al.
Abstract:Brucellosis, a zoonotic disease, has re-emerged in both humans and animals, causing significant economic losses globally. Recently, an increasing number of rifampicin-resistant
Brucella
strains have been isolated worldwide without detectable mutations in known antibiotic resistance genes. Here, this study identified the deletion of serine/threonine protein kinase (STPK) gene in
B. melitensis
as an efficient trigger for rifampicin resistance using bioinfor… Show more
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