Serious complications associated with regadenoson administration for myocardial perfusion imaging: A commentary

Hage, Fadi G.; Iskandrian, Ami E.

doi:10.1007/s12350-014-9985-2

Journal of Nuclear Cardiology

2014

DOI: 10.1007/s12350-014-9985-2

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Serious complications associated with regadenoson administration for myocardial perfusion imaging: A commentary

Fadi G. Hage

Ami E. Iskandrian

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Cited by 9 publications

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“…20 The incidence of second-degree AV block was also lower, with no occurrences in the regadenoson group compared to 3 occurrences in the adenosine group (P = .043). 20 More recent reports have described instances of asystole, 26 high-degree AV block, MI, cerebrovascular accidents, and seizures with regadenoson, 27,28 prompting an FDA warning against using regadenoson in patients with signs or symptoms of myocardial ischemia. The issue of serious complications encountered during stress testing using the different stress modalities has been recently reviewed in the Journal.…”

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Vasodilator stress agents for myocardial perfusion imaging

Saab

Hage

2017

Journal of Nuclear Cardiology

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In this issue of the Journal, Yao et al report on the prognostic value of adenosine triphosphate (ATP) myocardial perfusion imaging (MPI) with Technetium-99 sestamibi (Tc-99m) in a population aged 70 years and older.1 The ability to exercise in this population is expected to be rather limited. A total of 415 patients with suspected coronary artery disease (CAD) were identified and retrospectively enrolled in the study. The primary composite end point was major adverse cardiac events (MACE) and included death from a cardiac etiology, nonfatal myocardial infarction (MI), and late coronary revascularization ([60 days). Sixteen patients met exclusion criteria as they underwent early coronary revascularization B60 days after MPI. Reversible and/or fixed perfusion defects were considered abnormal and patients were followed over a mean of 3.45 ± 1.71 years. MACE occurred in 37 patients, including 9 cardiac deaths, and was significantly lower in patients with normal MPI, even after adjusting for other variables such as age [80 years, male gender, chest pain or dyspnea, hypertension, hyperlipidemia, diabetes mellitus, chronic kidney disease, atrial fibrillation, and abnormal ATP stress ECG. Each of the individual outcomes included in MACE was also significantly lower in patients with normal MPI. In addition, although patients aged C80 years had higher MACE rates than those aged 70-79 years when the summed stress score (SSS) was [8, the two groups had similar MACE rates when the SSS was B8. These results confirm the prognostic value of ATP-MPI in an elderly population with suspected CAD.The proportion of pharmacologic stress tests performed in the United States has steadily increased over the past several decades. Exercise stress testing is favored over vasodilator stress, since it is more physiological and since it assesses the functional capacity which provides important prognostic information.

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confidence: 99%

Vasodilator stress agents for myocardial perfusion imaging

Saab

Hage

2017

Journal of Nuclear Cardiology

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Serious complications associated with regadenoson administration for myocardial perfusion imaging

Kitt

Jiang

2015

Journal of Nuclear Cardiology

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Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging

Hage

AlJaroudi

2015

Journal of Nuclear Cardiology

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In this new feature of The Journal of Nuclear Cardiology we will summarize key articles that were published in the Journal in the previous year. In the first article of this 2-part series we concentrated on publications dealing with cardiac positron emission tomography, computed tomography, and neuronal imaging. This review will focus on myocardial perfusion imaging summarizing advances in the field including in diagnosis, prognosis, appropriateness, and safety of testing.

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Serious complications associated with regadenoson administration for myocardial perfusion imaging: A commentary

Cited by 9 publications

References 11 publications

Vasodilator stress agents for myocardial perfusion imaging

Vasodilator stress agents for myocardial perfusion imaging

Serious complications associated with regadenoson administration for myocardial perfusion imaging

Review of cardiovascular imaging in The Journal of Nuclear Cardiology in 2014: Part 2 of 2: Myocardial perfusion imaging

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