Serious fungal infections in Ecuador

2018

JoF

We aimed to estimate for the first time the burden of fungal infections in Uruguay. Data on population characteristics and underlying conditions were extracted from the National Statistics Institute, the World Bank, national registries, and published articles. When no data existed, risk populations were used to estimate frequencies extrapolating from the literature. Population structure (inhabitants): total 3,444,006; 73% adults; 35% women younger than 50 years. Size of populations at risk (total cases per year): HIV infected 12,000; acute myeloid leukemia 126; hematopoietic stem cell transplantation 30; solid organ transplants 134; COPD 272,006; asthma in adults 223,431; cystic fibrosis in adults 48; tuberculosis 613; lung cancer 1400. Annual incidence estimations per 100,000: invasive aspergillosis, 22.4; candidemia, 16.4; Candida peritonitis, 3.7; Pneumocystis jirovecii pneumonia, 1.62; cryptococcosis, 0.75; severe asthma with fungal sensitization, 217; allergic bronchopulmonary aspergillosis, 165; recurrent Candida vaginitis, 6323; oral candidiasis, 74.5; and esophageal candidiasis, 25.7. Although some under and overestimations could have been made, we expect that at least 127,525 people suffer from serious fungal infections each year. Sporothrichosis, histoplasmosis, paracoccidioidomycosis, and dermatophytosis are known to be frequent but no data are available to make accurate estimations. Given the magnitude of the burden of fungal infections in Uruguay, efforts should be made to improve surveillance, strengthen laboratory diagnosis, and warrant access to first line antifungals.

Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

Estimating the Burden of Serious Fungal Infections in Uruguay

Macedo-Viñas

2018

JoF

“…Summing all the risk populations described above, the total annual incidence of IA in Uruguay is estimated at 22.4/100,000 inhabitants. This is the highest incidence described in Latin America [15,16,25,30,31]. We believe this is due in part to the high incidence of COPD, chronic respiratory disease and lung cancer affecting our population compared to other countries in the region.…”

Section: Resultsmentioning

confidence: 84%

Estimating the Burden of Serious Fungal Infections in Uruguay

Macedo-Viñas

2018

Preprint

“…It is based on a proposed methodology that has been widely used, including in neighboring countries [49,50,51]. This is a challenging task due to the lack of a mandatory surveillance system for the majority of fungal diseases.…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting to compare the Colombian situation with that of some neighboring countries like Ecuador and Peru [49,50]. For example, the number of HIV patients not receiving antiretroviral treatment in Peru is higher than in Colombia, while the number of cases in Ecuador is not known.…”

Section: Discussionmentioning

confidence: 99%

Burden of Fungal Infections in Colombia

Álvarez-Moreno

Cortés

2018

JoF

Data with respect to the epidemiological situation of fungal diseases in Colombia is scarce. Thus, the aim of this study is to estimate the burden of fungal infections. A population projection for 2017 from the Colombian Department for National Statistics was used, as well as official information from the Ministry of Health and National Institute of Health. A bibliographical search for Colombian data on mycotic diseases and population at risk (chronic obstructive pulmonary disease, HIV infection/AIDS, cancer, and transplant patients) was done. The Colombian population for 2017 was estimated at 49,291,609 inhabitants, and the estimated number of fungal infections for Colombia in 2017 was between 753,523 and 757,928, with nearly 600,000 cases of candidiasis, 130,000 cases of aspergillosis, and 16,000 cases of opportunistic infection in HIV, affecting around 1.5% of the population. In conclusion, fungal infections represent an important burden of disease for the Colombian population. Different clinical, epidemiological, and developmental scenarios can be observed in which fungal infections occur in Colombia.