Sero-epidemiology of hepatitis B infection in an urban paediatric population in Turkey

Ertekin, Vildan; Selimoğlu, MA; Altınkaynak, Sevin

doi:10.1016/s0033-3506(02)00018-5

Cited by 19 publications

(15 citation statements)

References 7 publications

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“…An 11-year retrospective analysis of epidemiologic trends in HBV infections after the implementation of the nationwide vaccination program in Turkey revealed a stable anti-HBs incidence (43.6%) and intermediate HBsAg seroprevalence of 6.0% with a significant decrease from 12.3% in 2000 to 5.0% in 2010 [19]. Despite inclusion of older subjects and the fact that only 10.7% our subjects recalled they had been vaccinated against hepatitis B, HBsAg seropositivity prevalence (4.0%) was lower than previous reports [15,20,23]. Since 1998, HBV vaccine is being administered free of charge to all newborns.…”

Section: Discussioncontrasting

confidence: 61%

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Tözün

Özdoğan

Çakalǒglu

et al. 2015

Clinical Microbiology and Infection

234

147

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The present study was designed to determine the seroprevalence of hepatitis B and C virus (HBV, HCV) infections and risk factors in the Turkish general population. Participants were enrolled from urban and rural areas of the predetermined 23 EUROSTAT NUTS 2 region. A two-stage stratified sampling method was used to select participants from these regions (n = 5460; 50.9% females; mean (SD) age: 40.8 (14.7) years). Sociodemographics, clinical characteristics and risk factors were recorded at home visits. The seropositivity rates for hepatitis B surface antigen (HBsAg), anti-HCV, anti-HBs and anti-HBc total were 4.0%, 1.0%, 31.9% and 30.6%, respectively. Among HBsAg-positive cases, 94.5% were anti-HBe-positive, 70.2% were HBV-DNA-positive and 2.8% were anti-HDV total positive; 99.1% of HBV infections were of genotype D. Close contact with a hepatitis patient (OR 3.24; 95% CI 2.25-4.66; p < 0.001), living in the southeastern region (OR 2.74; 95% CI 1.7-4.45; p < 0.001), male gender (OR 1.77; 95% CI 1.28-2.46; p < 0.001), being married (OR 1.62; 95% CI 1.02-2.57; p 0.038), educational level less than high school (OR 1.53; 95% CI 1.04-2.26; p 0.03), orodental interventions (OR 1.54; 95% CI 1.01-2.35; p 0.047) and a history of non-disposable syringe use (OR 1.4; 95% CI 1.01-1.96; p 0.045) were significant determinants of HBsAg positivity. Age ≥50 years (OR 2; 95% CI 1.09-4.3; p 0.026) was the only significant predictor of anti-HCV positivity. In conclusion, our findings revealed an HBsAg positivity in 4% and anti-HCV positivity in 1% of the adult population and at least one-third of the population has been exposed to HBV infection in Turkey.

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Section: Discussioncontrasting

confidence: 61%

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Tözün

Özdoğan

Çakalǒglu

et al. 2015

Clinical Microbiology and Infection

234

147

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“…Over 350 million subjects are estimated to be chronically infected worldwide with HBV [2]. Turkey is a country of middle endemicity for HBV infection [1]. In the study presented, our results showed that the rate of HBV vaccination was very low due to the high cost of HBV vaccines.…”

mentioning

confidence: 60%

“…We carried out a study investigating seroepidemiology of HBV infection among 1091 school children, aged 6-17 years, living in the east of Turkey in 2000 and found the HBV seroprevalence to be 9.4% [1]. Here we report the immunization rate of hepatitis B in this population and the factors affecting their vaccination status.…”

mentioning

confidence: 82%

Effects of several socio-demographic factors on hepatitis B immunization rates

Ertekin

Selimoğlu

2004

European Journal of Gastroenterology & Hepatology

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Hepatitis B virus (HBV) infection is one of the major public health problems in several regions of the world, especially developing countries with low socioeconomic status. The HBV rate is known to be 25-60% in Turkey, with the highest prevalence in east and south-east regions.We carried out a study investigating seroepidemiology of HBV infection among 1091 school children, aged 6-17 years, living in the east of Turkey in 2000 and found the HBV seroprevalence to be 9.4% [1]. Here we report the immunization rate of hepatitis B in this population and the factors affecting their vaccination status.Of 1091 children, 512 (46.9%) were female and 579 (53.1%) were male. Mean age was 12.3 AE 2.3 years. Thirty-two children had the history of HBV immunization. The overall frequency of HBV vaccination rate was 2.9% (32 children). Of these, 17 (53.1%) were female and 15 (46.9%) were male. There was no difference in vaccination rates with respect to gender. The mean age of vaccinated children was 8 AE 1.8 years.As the age of the children increased, the proportion of those vaccinated decreased but there was no difference in vaccination status in respect to age, statistically (P . 0.05). According to the educational level of mothers, 1.1% (2/186) had no literacy, 2.3% (15/640) had had a primary school education, 4.5% (11/244) had had a secondary or high school or college education, and 19% (4/21) had graduated from university. The HBV immunization rates increased with the educational levels of mothers (P , 0.05). Of families, while 65.6% had high socio-economic status, 28.1% had moderate, and 6.3% had low socio-economic level. Vaccination rates were significantly correlated with the socio-economic status (P , 0.05). Of subjects included in the study, 49.4% had three or fewer siblings and 50.6% had four or more siblings. With regard to immunization rates, subjects who had three or fewer siblings or who had four or more siblings represent 4.5% and 1.5%, respectively, of the total. HBV infection is of major international importance. Over 350 million subjects are estimated to be chronically infected worldwide with HBV [2]. Turkey is a country of middle endemicity for HBV infection [1]. In the study presented, our results showed that the rate of HBV vaccination was very low due to the high cost of HBV vaccines. Turkish children have been vaccinated against HBV infection free of charge since 1998 [3]. Because only school children were included in the study we performed in 2000, they were not included in the general HBV immunization programme so their vaccines were paid for by their own families. In the present study, the socio-demographic characteristics, especially the educational level of the mothers, sibling size and socio-economic status were significantly related to the HBV vaccination status. None of the other factors (age, gender) significantly improved the model. In particular, we could not find any significance when we evaluated the results with respect to the educational status of fathers. The HBV immunization rates decrease...

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“…Epidemiological studies examining the seroprevalence of HBsAg report a prevalence of 2%-7% in Turkey (4)(5)(6)(7)(8). However, most of these data were based on retrospective analysis of cohorts comprising blood donors or risk groups.…”

mentioning

confidence: 99%

Seroprevalance of hepatitis B and C infections in Turkey

Yapalı¹

2017

Turk J Gastroenterol

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Sero-epidemiology of hepatitis B infection in an urban paediatric population in Turkey

Cited by 19 publications

References 7 publications

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Seroprevalence of hepatitis B and C virus infections and risk factors in Turkey: a fieldwork TURHEP study

Effects of several socio-demographic factors on hepatitis B immunization rates

Seroprevalance of hepatitis B and C infections in Turkey

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