Sero-prevalence of Bovine Brucellosis and associated risk factors in mbeya region, Southern highlands of Tanzania

Sagamiko, Frederick; Muma, John Bwalya; Karimuribo, Esron D.; Mwanza, A.M.; Sindato, Calvin; Hang’ombe, Bernard M.

doi:10.1016/j.actatropica.2017.11.022

Cited by 24 publications

(31 citation statements)

References 19 publications

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“…In this study, herds in which cattle grazed together with small ruminants were significantly more likely to be seropositive than cattle-only herds, which is consistent with similar studies that found that mixing cattle and small ruminants was a significant predictor of brucellosis [ 47 , 48 ]. This suggests that small ruminants may play a role in the maintenance and persistence of brucellosis in cattle in Rwanda since the former are not vaccinated.…”

Section: Discussionsupporting

confidence: 91%

Seroprevalence and Associated Risk Factors of Bovine Brucellosis at the Wildlife-Livestock-Human Interface in Rwanda

et al. 2020

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Bovine brucellosis is endemic in Rwanda; however, little information is available on seroprevalence and risk factors. Therefore, a cross-sectional study was conducted among cattle farmed at the wildlife-livestock-human interface (n = 1691) in five districts and one peri-urban district (n = 216). Cattle were screened using the Rose Bengal test, then the results were confirmed by indirect enzyme-linked immunesorbent assay. Potential risk factors were determined with a questionnaire and analyzed for their association with seropositivity. In all districts, the animal and herd-level seroprevalence was 7.4% (141/1907) and 28.9% (61/212), respectively, 8.3% (141/1691) and 30.9% (61/198) at the interface, and 0.0% (0/216) in peri-urban areas. Among the potential risk factors, old age (≥5 years), cattle farmed close to wildlife, herds of cattle and small ruminants, history of abortions, and replacement animals were significantly associated with brucellosis (p < 0.05). Low awareness of zoonotic brucellosis, assisting calving without biosafety protection, drinking raw milk, and manual milking were each observed in more than 21.7% of cattle keepers whose herds were seropositive. This study confirmed brucellosis endemicity in cattle farmed close to wildlife in Rwanda, suggesting the need to focus control efforts in these areas. Educated farmers with a high awareness of zoonotic brucellosis had low bovine brucellosis seropositivity, which emphasizes the importance of education.

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Section: Discussionsupporting

confidence: 91%

Seroprevalence and Associated Risk Factors of Bovine Brucellosis at the Wildlife-Livestock-Human Interface in Rwanda

et al. 2020

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“…For gravid domestic ruminants, the prevalence (5%; 95% CI: 3.1–8) was within the range previously reported in Tanzania (Sagamiko et al, ; Shirima, ). In this study, the abortion rate in cattle (5.8%) was lower compared to the previous reports in Tanzania (Mathew, ; Mdetele et al, ).…”

Section: Discussionsupporting

confidence: 86%

“…Brucellosis has been reported in different areas of Tanzania (Asakura, Makingi, Kazwala, & Makita, ; Assenga, Matemba, Muller, Malakalinga, & Kazwala, ; Bouley et al, ; Kassuku, ; Kunda et al, ; Sagamiko et al, ; Swai & Schoonman, ); however, the contribution of this disease to the recorded abortions in diverse species remains to be appraised. The disease was also reported previously in Kagera (Kiputa, Kimera, & Wambura, ), and its prevalence seemed to have enhanced the transmission risk of the disease in traditional herds.…”

Section: Introductionmentioning

confidence: 99%

Association of brucellosis to abortions in humans and domestic ruminants in Kagera ecosystem, Tanzania

Ntirandekura

Matemba

Kimera

et al. 2020

Transbound Emerg Dis

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Brucellosis is a worldwide zoonotic disease of socio‐economic importance. Understanding the association of this disease with pregnancy outcome has the potential of contributing to the reduction of its reproductive burden in humans and animals among pastoral communities in Tanzania. A prospective cohort study was conducted in Kagera Region on pregnant women (n = 76) and gravid ruminants (121 cattle, 125 goats and 111 sheep). Exposed and non‐exposed groups to brucellosis were followed for 6 months (from 15 November 2017 to 15 April 2018). Sera were collected and analysed using Rose Bengal Test (RBT) and Fluorescence polarization assay (FPA) test. Measures of effect, univariable and multivariable logistic regression analyses were computed. Positivity to both RBT and FPA tests was 21% (95% CI: 12.5–32) in pregnant women and 5% (95% CI: 3.1–8) in gravid ruminants. Among aborted cases, four women (out of nine), two cows (out of seven), two goats (out of 26) and zero sheep (out of 11) were positive to brucellosis. The abortion rate in humans and ruminants was 11.8% and 12.3%, respectively. Seropositivity to brucellosis was similar in aborted and non‐aborted cases in humans (p = .08) and in ruminants (p = .2). At the population level, brucellosis was associated with abortions (population attributable risk: PAR) at 3.5% in pregnant women and at 0.5% in gravid ruminants in the study area. Infections to brucellosis were increased in exposed pregnant women (OR = 19; 95% CI: 1.8–203, p = .01) and in cattle (OR = 11; 95% CI: 1.3–88, p = .02). There is an indication that brucellosis could be contributing to abortions in pregnant women and domestic ruminants Kagera Region. Molecular tools could support more the results from serological tests to avoid cross‐reaction with other pathogen agents. Control of brucellosis in animals is likely to reduce the threat of abortions in humans.

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“…The temperature ranges between −6°C in the highlands and 29°C on the lowlands, while the average rainfall is 900mm per year. Details of the study area have been described in our earlier publication [22]. According to the 2012 national census, the region has an estimated human population of about 2,707,[23] among which 1, 297,738 are males and 1, 409, 672 are females.…”

Section: Methodsmentioning

confidence: 99%

“…A total of 425 humans comprising 75 shepherds from 37 Brucella positive herds, 11 livestock professionals, 57 butcher men, 186 abattoir workers from 4 abattoirs, 72 persons engaged in cattle milking and 24 animal product consumers were recruited in the study. The numbers of shepherds to be sampled were pre-determined from known Brucella positive herds based on our earlier study [22]. Among the households with infected cattle herds, only 37 were enrolled out of 53 herds.…”

Section: Methodsmentioning

confidence: 99%

Seroprevalence of human Brucellosis and associated risk factors among high risk occupations in Mbeya Region of Tanzania

Sagamiko

Muma

Karimuribo

et al. 2019

Preprint

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14Background 15 Brucellosis is an infectious zoonotic disease that affects humans, livestock and wildlife. 16 Methods 17 A cross-sectional study was conducted in Mbeya region between November 2015 and January 18 2016 to investigate the seroprevalence of human brucellosis and identify associated risk factors 19 among individuals in risky occupations in Mbeya Region. A total of 425 humans from six 20 occupational categories were serially tested for Brucella antibodies using the Rose Bengal Plate 2 21Test (RBPT) and competitive Enzyme Linked Immunosorbent Assay (c-ELISA), for screening 22 and confirmation, respectively. A questionnaire survey was administered to participants collect 23 epidemiological data. 24 Results 25The overall seroprevalence among the high risk occupational individuals was 1.41% (95% CI: 26 0.01-0.03). Seroprevalence among the different occupations were as follows: shepherds 1.33% 27 (95% CI: 0.14-0.22); butcher men 5.26% (95% CI: 0.10-0.17) and abattoir workers 1.08% 28 (95% CI: 0.39-0.49). Seroprevalence was noted to vary according to occupation type, milk 29 consumption behaviour, age and sex. Butcher men recorded the highest seroprevalence (5.0%) 30 while individuals who consumed unboiled milk had a higher seroprevalence (1.56%) compared 31 to those who drunk boiled milk. High seropositivity (2.25%) was observed among the age 32 group of 1-10 years while male individuals had a higher seroprevalence (1.41%) than females 33 (0%). Butcher men were at higher risk of exposure compared to other professions. 34 Conclusion 35Our findings show the presence of brucellosis in occupationally exposed individuals in Mbeya 36 region. There is need to sensitize the exposed individuals in order to reduce the risk of acquiring 37 Brucella infections from animals and animal products This also calls for public health 38 awareness about the disease, and implementation of control measures that will prevent further 39 spread of brucellosis within and outside the study area.. 40 41

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Sero-prevalence of Bovine Brucellosis and associated risk factors in mbeya region, Southern highlands of Tanzania

Cited by 24 publications

References 19 publications

Seroprevalence and Associated Risk Factors of Bovine Brucellosis at the Wildlife-Livestock-Human Interface in Rwanda

Seroprevalence and Associated Risk Factors of Bovine Brucellosis at the Wildlife-Livestock-Human Interface in Rwanda

Association of brucellosis to abortions in humans and domestic ruminants in Kagera ecosystem, Tanzania

Seroprevalence of human Brucellosis and associated risk factors among high risk occupations in Mbeya Region of Tanzania

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