Sero-prevalence of Helicobacter pylori Infection in Neyshabur, Iran, During 2010-2015

Abstract

Backgrounds & Objective: The Helicobacter pylori prevalence has continuously decreased during recent years in Iran. The current study aimed at determining H . pylori prevalence in Neyshabur city, Northeast Iran, during 2010-2015. Methods: The current epidemiologic survey was conducted in Neyshabur from 2010 to 2015 to determine the prevalence of H. pylori infection. A total of 11596 participants (3681 male with the mean age of 31.7±6.2 years and 7915 female with mean age of 68.3±4.7 years) were included. The enzyme-linked immunosorbent assay kits for the detection of H. pylori and Stat Fax 3200® Microplate Reader (USA) with a sensitivity of 95% and specificity of 98% were used. Titers above 12 units were considered positive for IgG, IgA, and IgM (negative <8, equivocal 8 to 12, and positive >12 U). The Chi-square t test and F test were used to analyze data. Results and Conclusion: The overall IgA, IgG, and IgM seropositive samples among the study participants were 852 (7.2%), 9000 (72.8%), and 1256 (5.2%), respectively. The IgA seropositivity was significantly high among the age group above 51 years, compared with the other age groups. Moreover, the IgG and IgM seropositivity were significantly high among the age groups 41 to 50 and 31 to 40 years respectively, compared with the other age groups. There was no significant difference between male and female cases regarding IgA and IgG seropositive samples, but IgM level was significantly higher among females, compared with that of the male cases. Furthermore, there was no significant alteration in IgA, IgG, and IgM seropositivity during 2010-2014 in Neyshabur. The prevalence of H. pylori in Neyshabur was high in the healthy population. Furthermore, the H. pylori prevalence did not change from 2010 to 2014 in the studied city. Effective approaches to improve health, educational, and socioeconomic status should be implemented to minimize and control H. pylori infection.

Determination of Helicobacter Pylori Infection Prevalence by Non-invasive Methods

“…These findings are in agreement with several studies which found a significant effect of age increase on the levels of H. pylori seropositive cases (44,45), whilst others indicated contrasting results (38,46). In terms of gender, similar to an earlier study, no significant association was observed between IgG and IgA levels and sex, but positive cases of IgM were significantly higher in women compared to men (42). However, there is a conflict between our results and another study, which indicated higher IgG, IgM, and IgA seroprevalence cases in men compared with women (45).…”

“…However, other studies found 18% and 67.4%, which are inconsistent with our results (40,41). The IgM results were in accordance with those studies, reporting that 2.4%, 5.2%, and 5.81% of the subjects were positive for H. pylori (37,42,43). On the other hand, IgM seropositivity was 16.1% and 34.9% in some studies (44,41) that are inconsistent with our findings.…”

Helicobacter pylori infection among patients presenting with dyspepsia at a primary care setting in Cameroon: seroprevalence, five-year trend and predictors

“…During the last decade, while several studies in Africa have described fluctuating trends in H. pylori seropositivity [16, 17], this has not been very much the same elsewhere, with a study in Iran reporting a constant trend from 2010 to 2015 [28].…”

Epidemiology of Helicobacter pylori infection

“…The results of a cross‐sectional study in Northeast Iran conducted from 2010 to 2015, and involving 11 596 participants were reported by Salehi et al . The H. pylori IgG antibody positivity was 72.8%; no change in the seroprevalence was observed during the study period.…”