Serodeconversion of HIV Antibody‐Positive AIDS Patients Following Treatment with V‐1 Immunitor

Abstract

It is extremely rare when HIV seropositive adult patients experience spontaneous loss of antibodies, that is, seroreversion. The disappearance of HIV antibodies was occasionally attributed to iatrogenic intervention—serodeconversion. Such interventions include: HAART; oral interferon; Chinese herbal remedies; and therapeutic AIDS vaccines derived from pooled blood. Oral therapeutic, alloimmune AIDS vaccine, V-1 Immunitor (V1), was administered to 60000 HIV-positive Thai patients. The administration of V1 resulted in serodeconversion among 23 individuals. The patient group consisted of 9 females (39%) and 14 males (61%) including two 2-year-old boys. The age range was 2–58 years with mean/median 29/29.3 years. Patients were tested seropositive for HIV at least once before being enrolled on V1. The duration of treatment until discovery of seronegative status ranged between 2 weeks and 15 months with average/median 7.2/8 months. Time to seronegativity was correlated with baseline disease stage (R = 0.62; P = .002). The seronegative status was positively associated with V1-induced undetectable or low viral load (R = 0.65; P = .0008). The odds ratio analysis comparing the outcome of our study with published surveys of diagnostic accuracy of laboratory tests suggested that the probability of HIV antibody testing error was remote (P < .000001). The possible causes responsible for this unusual phenomenon are discussed.

5-Month Herbal Therapy and Complete Sero-Reversion with Recovery in an Adult HIV/AIDS Patient

“…Complete sero-reversion had been documented in infants with early commencement of anti-retroviral therapy and in adults that took vaccines [5,24,25]. The sustained sero-reversion for 6 years after the discontinuation of therapy by the HIV patient pointed to the potentials of the herbal remedy.…”

Chronic and Early Antiretroviral Therapy Impact Human Immunodeficiency Virus (HIV) Serological Assay Sensitivity, Leading to More False-Negative Test Results in HIV Diagnosis

“…This might lead to a partial or complete loss of antibody detection which is well known for HIV infected newborns or young children taking ART [5][6][7][8]. However, only a few clinical cases of seroreversion or incomplete seroconversion have been reported in HIV-1 patients starting ART as adult [9][10][11][12]. Shortening the period to which the patient is exposed to replicating and disseminating viruses tends to diminish the immune response [4,13].…”

Seronegative conversion of an HIV positive subject treated with <i>Nigella sativa</i> and honey

“…Bone marrow transplantation is expensive and risky. The vaccines content and procedures were scantly documented or available to the public (Abalaka 2004;Metadilogkul et al, 2009)). Likewise not all HIV patients that were commenced on HAART early became sero-reverted (Kassutto et al, 2005).…”