Serodiagnosis of Crimean-Congo haemorrhagic fever

Burt, Felicity J.; Leman, Patricia A.; Abbott, James; Swanepoel, Robert

doi:10.1017/s0950268800068576

Cited by 87 publications

(76 citation statements)

References 17 publications

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“…Early studies in South Africa found that most patients who went onto survive the disease had detectable anti-CCHFV IgM by day 7 and IgG by day 7-9 of illness, while no response was detected in fatally infected individuals (Burt et al, 1994;Shepherd et al, 1989c;van Eeden et al, 1985b). The correlation of antibody responses with survival has been demonstrated more recently in patients in Turkey and Kosovo (Ergonul et al, 2006a;Saksida et al, 2010).…”

Section: Predictors Of Survival or Deathmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Predictors Of Survival or Deathmentioning

confidence: 99%

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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“…Spesifik IgM 4 aylık postinfeksiyon'dan sonra belirlenememekte, ancak IgG'ler en az 5 yıl süresince belirlenebilir durumda kalmaktadır. ELISA metodları spesifik ve hassastır (17). Son zamanlarda, rekombinant-nükleoprotein bazlı IgG ELISA kiti, KKKAV enfeksiyonlarının teşhisinde kullanım amaçlı geliştirilmiştir (18,19 (21).…”

Section: Discussionunclassified

Kırım Kongo kanamalı ateşi virüsü nükleoproteininin rekombinant olarak elde edilmesi ve ELISA'da kullanımı

Dönmez¹,

Pınarbaşı²

2016

Ege Tıp Dergisi

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“…8,10 Serologic tests such as complement fixation, immunodiffusion, and hemagglutination inhibition, neutralizing antibody response, indirect IFA and ELISA are useful tests for CCHF diagnose. 44,45 Specific immunoglobulin (Ig)G and IgM antibodies against CCHFV may be detected in serum by ELISA method from six days after the onset of symptoms. Either the presence of IgM or a 4-fold rise in the titer of IgG antibody in serum samples between the acute and convalescence phases is diagnostic for CCHF.…”

Section: Cchf Diagnosismentioning

confidence: 99%

Crimean-Congo Hemorrhagic Fever

Elaldı¹,

Kaya²

2014

Journal of Microbiology and Infectious Diseases

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Crimean-Congo hemorrhagic fever (CCHF), a tick-borne viral hemorrhagic fever, is a zoonotic infection that caused by CCHF virus (CCHFV) of the family Bunyaviridae, genus Nairovirus. Transmission occurs mainly by Hyalomma m. marginatum tick exposure. Blood and bloody excretions of the patients are highly infectious and contact of skin and mucous membrane may lead to CCHF transmission. CCHF was described firstly in the Crimean peninsula in 1944, in former Soviet Union and in Kelkit Valley in 2002 in Turkey. By the year 2013, it has been notified in more than 30 countries of Asia, the Middle East, Southeastern part of Europe and Africa. The disease is characterized by fever and thrombocytopenia, in severe cases, hemorrhage and shock. Although, the case fatality rate for the infection is generally ranged from 10 to 50%, it was reported as 5% for Turkey. Main targets of CCHFV are immune cells and endothelium. Both innate and adaptive immunity are important for fighting against CCHFV in the host. Headache, fever, fatigue and muscle, joint pain, conjunctival injection, facial hyperemia, thrombocytopenia, elevated liver enzymes, hepatomegaly and splenomegaly are the main symptoms and findings for CCHF. Hemorrhagic manifestations including ecchymosis, melena, hematochezia, hematemesis, and epistaxis are commonly seen in severe cases. Supportive treatment is essential and nowadays neither a special drug, nor safe vaccine for humans is available for the treatment and prevention of CCHF. In case of penetrating injury with contaminated material, the oral ribavirin prophylaxis may be offered after the area being washed with soapy water and ethanol. J Microbiol Infect Dis 2014; Special Issue 1: S1-S9

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Serodiagnosis of Crimean-Congo haemorrhagic fever

Cited by 87 publications

References 17 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Kırım Kongo kanamalı ateşi virüsü nükleoproteininin rekombinant olarak elde edilmesi ve ELISA'da kullanımı

Crimean-Congo Hemorrhagic Fever

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