Seroepidemiological survey of rotavirus in Thailand, 1978

Maneekarn, Niwat; Shinozaki, Tatsuhiko; Arai, Kozo; Yamada, Mitsuo; Yamazi, Yukio; Watari, Eiji; Suzuki, Hiroshi

doi:10.1272/jnms1923.47.570

Cited by 3 publications

(4 citation statements)

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“…It was found that about one-third (34.0%) of children hospitalized with diarrhea in Chiang Mai area were infected with group A rotavirus. The results are consistent with the findings that had been reported previously in Thailand [Maneekarn et al, 1980;Puthavathana et al, 1981;Jayavasu et al, 1982;Louisirirotchanakul et al, 1984;Wasi et al, 1984] and elsewhere [Estes, 2001].…”

Section: Discussionsupporting

confidence: 92%

Emergence of human G9 rotavirus with an exceptionally high frequency in children admitted to hospital with diarrhea in Chiang Mai, Thailand

et al. 2005

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Among 315 fecal specimens collected from children hospitalized with diarrhea in Chiang Mai, Thailand, in 2000-2001, group A rotavirus was detected in 107 (34.0%). Of these, 98 (91.6%) were G9, 6 (5.6%) were G3 and 3 (2.8%) were G2, respectively. Identification of their P-types demonstrated that 103 (96.3%) were P[8], 3 (2.8%) were P[4], and 1 (0.9%) was P[3] genotypes. Determination of G- and P-type combination revealed that all of G9 isolates were associated with P[8]. G9P[8] was the most predominant genotype and accounted for the majority (91.6%) of rotaviruses detected in this study. Molecular characterization of these G9 isolates demonstrated that all had long electropherotype, 96 of 98 (98.0%) belonged to subgroup II, one belonged to subgroup I and the other one was subgroup unidentifiable. All of G9 isolates possessed NSP4 genetic group B except for one isolate that showed dual genetic group specificities, B and C. The full-length VP7 gene nucleotide sequences among 15 representatives of these G9 strains were found to be highly homologous with percent identities of 99.3%-100%. Comparison with other G9 strains recently isolated showed that their nucleotide sequences were closely related to those of the US strain, US1205 (98.7%-99.0%) and Thai strain, 97CM108 (98.1%-99.0%). Interestingly, they were most closely related to the Japanese strain, 00-SG2509VP7, isolated in the same epidemic season, with percent nucleotide sequence identity of 99.4%-99.8%. The data imply that G9 strains isolated in this study and a G9 strain isolated in Japan in the year 2000 might have descended from the same ancestor.

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Section: Discussionsupporting

confidence: 92%

Emergence of human G9 rotavirus with an exceptionally high frequency in children admitted to hospital with diarrhea in Chiang Mai, Thailand

et al. 2005

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“…In Thailand, rotavirus is the leading pathogen that causes diarrhea in children, 14,15 and it is responsible for about 30–36% of diarrheal disease in hospitalized cases. 14–17 Studies of rotavirus in Thailand were initially performed approximately two decades ago, 14,16,18,19 and now many studies have accumulated. Rotavirus studies have been undertaken on several aspects, including the clinical features, the diagnosis, the methods used for the detection and typing, the prevalence and the serotypes of rotavirus in Thailand.…”

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confidence: 99%

Epidemiology of rotavirus infection in Thailand

Maneekarn

Ushijima

2000

Pediatrics International

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Rotavirus is a major cause of acute severe diarrhea in children worldwide and an important cause of death among young children in developing countries. Group A rotaviruses are antigenically complex and multiple serotypes infect humans. Reassortant rotavirus vaccines are now available which offer protection against severe illness caused by rotavirus serotypes G1-4. Before vaccines are introduced into target populations, it is necessary to establish the baseline data of the epidemiology of rotavirus infection in those countries. The purpose of the present study is to provide information related to the epidemiology of rotavirus infection in Thailand. All rotavirus studies performed in Thailand were found through Medline and Thai Index Medicus searches. A total of 26 of the most relevant studies published in international and national journals are reviewed. Most studies reported that the prevalence of rotavirus infection in Thailand was 27-34%, although a few studies have reported a prevalence above this range. The peak seasonal distribution of rotavirus infection among children hospitalized with diarrhea in Thailand was seen in the dry cool seasons: October to February. The prevalence of rotavirus infection was most frequently found in children aged 6-11 months up to 2 years. G1 was the most prevalent serotype in Thailand, followed by G2, G4 and G3, respectively. At least three G serotypes, mostly G1, G2 and G4, are seen to coexist in Thailand each epidemic year and in some studies all four G-serotypes were reported in the same epidemics. In a 1996-1997 study, G9 was the third prevailing serotype after G1 and G2, respectively. These results indicate that rotavirus epidemics occur in Thailand every year and children are the most affected population. In Thailand, although G1-G4 have been reported, G1 is the most prevalent serotype in each epidemic and G9 is becoming increasingly common.

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“…Only 10 out of 21 HRV-positive fecal specimens were obtained at the same or successive weeks of diarrhoeal episodes ( HRV was detected in 19 (68%) among the 28 index children from their stool specimens collected weekly during the two years, and twice in two (7.1%) children in separate weeks, which indicates that 68% of the newborn babies of this study group were infected, 7.1% experienced reinfection but 32% were not infected by rotavirus during the first two years after birth. Seroepidemiological data in 1978 showed that 80% of children under two years of age had anti-rotavirus antibody (Maneekarn et al, 1980) . Seasonal incidence of HRV-positive fecal specimens from newborn babies delivered in October and November indicated that 29% of the index children experienced primary infection of rotavirus in the first dry-cool season, 9.5% in the first rainy season, 57% in the second dry-cool season and 4.8% in the second rainy season of their life.…”

Section: Resultsmentioning

confidence: 99%

“…We made a seroepidemiological survey of rotavirus in Thailand in 1978 (Maneekarn et al, 1980) In 1984 and 1985, we detected rotavirus antigens in 46% out of 188 diarrhoeal patients by ELISA in Chiang Mai, Bangkok and Khon-Kaen , and made some preliminary work on the fecal IgA antibody responses to rotavirus infection of the patients in Chaiang Mai . In this report, 28 newborns delivered at a hospital in Chiang Mai in October and November, 1988 went followed up from birth for two years for the rotavirus infection.…”

Section: Introductionmentioning

confidence: 99%