Seroepidemiology of cytomegalovirus antibodies in Hiv-positive and Hiv-negative adults in Nigeria

Adeiza, Mukhtar Abdulmajid; Dalhat, MM; Musa, Bolanle O. P.; Muktar, HM; Garko, SB; Habib, AG

doi:10.4103/2384-5147.190852

Cited by 2 publications

(5 citation statements)

References 2 publications

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“…A study conducted by Adeiza et al reported highest CMV IgG seroprevalence (93.5%) in 16-25 years age group and highest CMV IgM seroprevalence (16.1%) in 26-35 years age group. 8 In our study, CMV IgG seroprevalence in older age 51-60 years seen was 100% which is comparable to study by Bakri et al (2016) who also reported seroprevalence of 100% in old age group 11 . Other studies by Kenneson and Cannon (2007); Staras et al (2006) reported that seroprevalence increases to >80% by the age of 60.…”

Section: Discussionsupporting

confidence: 88%

“…This finding is similar to that of Matos et al in Brazil and Adeiza et al in Nigeria. 8,14 In our study, CMV DNA was detected by Real-Time PCR from 31.58% samples. This is comparable to a study conducted by Halima et al who also detected CMV DNA in 31% of samples taken from immunocompromised patients.…”

Section: Discussionmentioning

confidence: 52%

“…12 Adeiza et al also observed higher CMV IgM seroprevalence among males. 8 However, Bakri et al reported a higher percentage of CMV IgG among females (78.35%) as compared to males (64.28%). 11 Shukla et al also reported higher female positivity (59.72%) of CMV DNA as compared to male positivity (45.21%).…”

Section: Discussionmentioning

confidence: 94%

“…Similarly, a study conducted by Adeiza et al in Nigeria detected CMV IgG in 86% and CMV IgM in 13.2% in HIV positive patients. 8 According to a study by Velvizhi et al in India, it was found that 7.6% blood donors were positive for CMV IgM and 82.6% donors were positive for CMV IgG. 9 Most studies worldwide have shown the seroprevalence of CMV IgG to be between 40% and 90%.…”

Section: Discussionmentioning

confidence: 99%

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Detection and Quantification of Cytomegalovirus in Immunocompromised Patients

Arora¹,

Devi²,

Singh³

et al. 2018

IJCMR

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Introduction: CMV disease ranges from asymptomatic infection in immunocompetent people to severe and lifethreatening infections in neonates and immunocompromised patients. The present study was undertaken to study the seroprevalence of CMV and use of Real-time PCR in detection and quantification of CMV in immunocompromised patients. Material and Methods: A total of 57 samples were tested for CMV IgM and CMV IgG by ELISA technique. The detection and quantification of CMV DNA was done by real time PCR. Results: Out of 57samples, 6 (10.53%) tested positive for CMV IgM, 50 (87.72%) were positive for CMV IgG and 18 (31.58%) were positive for CMV DNA by PCR. Among 18 PCR Positive cases, 6 (33.334%) cases showed viral load of 1x10 3 IU/ml. 4 (22.22%) cases each showed viral load of 1x10 4 IU/ml, 1x10 5 IU/ml, 1x10 6 IU/ml respectively. There is no statistical association of age, gender and geographical distribution with CMV IgM, CMV IgG and CMV DNA positivity. (P>0.05). Conclusion: This study demonstrated that Real-time PCR is more reliable test than serological ELISA test in the diagnosis of cytomegalovirus as Real-time PCR detects and quantifies viral DNA which is useful in predicting the patient's risk for disease and monitoring the effect of antiviral therapy. Good hygiene and infection control practices are advised to prevent CMV transmission.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 52%

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

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Detection and Quantification of Cytomegalovirus in Immunocompromised Patients

Arora¹,

Devi²,

Singh³

et al. 2018

IJCMR

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“…Meanwhile, a similar result has been observed by Seale et al ( 2006 ), Arora et al ( 2018 ), and Franjića et al ( 2020 ). In contrast, Adeiza et al ( 2016 ) mentioned higher rates of CMV-IgM seroprevalence in males, while Shukla et al ( 2015 ) and Bakri et al ( 2016 ) reported a higher incidence of CMV-IgG seroprevalence among females.…”

Section: Discussionmentioning

confidence: 93%

Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

Hassan

Zekry²,

Heikal³

et al. 2023

Parasitol Res

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Autism is a neurodevelopmental disorder with a significantly increased incidence rate across the world over the past few years. Toxoplasmosis and cytomegalovirus (CMV) infection are globally prevalent and have been associated with diverse neurological and psychiatric disorders. A few studies have demonstrated the role of toxoplasmosis and CMV as potential etiological factors for autism. Accordingly, this study was performed to estimate the relationship between toxoplasmosis and CMV infection in children with autism as well as to assess their impact on the Childhood Autism Rating Scale (CARS) score. A total of 45 autistic children (6 girls, 39 boys) and 45 (21 girls, 24 boys) healthy control children were enrolled in our study. Their blood samples were collected and tested for the presence of Toxoplasma and CMV (IgG and IgM) antibodies and DNA by ELISA and real-time PCR (RT-PCR), respectively. Toxoplasmosis was detected in 11 (24.4%) autistic children through the ELISA [10 (22.2%) IgG + /IgM − and 1 (2.2%) IgG + /IgM +]; however, RT-PCR assay recorded only 1 positive case (2.2%), while it was detected in 10 (22.2%) control children through ELISA [9 (20%) IgG + /IgM − and 1 (2.2%) IgG + /IgM +] and 1 (2.2%) by RT-PCR. On the other hand, CMV infection was detected in all autistic children with 44 (97.8%) testing positive by ELISA [24 (53.3%) IgG + /IgM − , 18 (40%) IgG + /IgM + and 2 (4.4%) IgG − /IgM +] and 25 (55.6%) testing positive by RT-PCR assay. In addition, ELISA assay recorded 43 (95.6%) [19 (42.2%) IgG + /IgM + and 22 (48.9%) IgG + /IgM − and 2 (4.4%) IgG-/IgM +] and RT-PCR recorded 21 (46.7%) positive samples in control children with CMV. No significant difference was noted between autistic and control children for the overall prevalence of Toxoplasma or/and CMV infection. Similarly, the CARS score indicated a non-significant difference with Toxoplasma or/and CMV infection. Our data does not show an association between autism and toxoplasmosis or/and CMV infection. Nevertheless, considering that autistic children are at a high risk of contracting these infections, further studies with a larger sample size are recommended.

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Seroepidemiology of cytomegalovirus antibodies in Hiv-positive and Hiv-negative adults in Nigeria

Cited by 2 publications

References 2 publications

Detection and Quantification of Cytomegalovirus in Immunocompromised Patients

Detection and Quantification of Cytomegalovirus in Immunocompromised Patients

Toxoplasmosis and cytomegalovirus infection and their role in Egyptian autistic children

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