Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006

Sissoko, Daouda; Ezzedine, Khaled; Giry, Claude; Moendandzé, Amrat; Lernout, Tinne; D’Ortenzio, Éric; Pettinelli, François; Malvy, Denis

doi:10.1371/journal.pone.0014141

Cited by 14 publications

(11 citation statements)

References 28 publications

(27 reference statements)

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“…Sera were most frequently reactive with DENV1 and DENV3 and less frequently with DENV2 and DENV4. These results are in keeping with the history of dengue epidemics on the archipelago during the last seventy years: DENV1 epidemics was recorded in 1948 and 1993, DENV2 in 1984 [20] and DENV3 in 2010 [21] To our knowledge, serotype 4 has never been reported as causing an epidemic in the Indian Ocean region though some uncertainty remains with regard to serotypes that have been circulating during the 1948 and 1984 epidemics in Comoros [22]. Yet, neutralizing antibodies to DENV4 were detected in the present series in over half of titrated sera (44/78).…”

Section: Discussionsupporting

confidence: 84%

“…In that island, a cross-sectional serologic survey conducted in 2006 during an inter-epidemic period for dengue, showed a rate of DENV-specific IgG antibodies of 22.7% with an age-specific prevalence peaking at 38.8% in the 25–54 years age group while the 2–14 age group was almost completely preserved [20]. Interestingly, Comorian native inhabitants aged 15 years or over, who had immigrated to Mayotte, were around ten-times more affected than individuals of the same age born in Mayotte [20]. …”

Section: Discussionmentioning

confidence: 99%

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Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)

Dellagi

Salez

Maquart³

et al. 2016

PLoS Negl Trop Dis

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A cross sectional serological survey of arboviral infections in humans was conducted on the three islands of the Union of Comoros, Indian Ocean, in order to test a previously suggested contrasted exposure of the three neighboring islands to arthropod-borne epidemics. Four hundred human sera were collected on Ngazidja (Grande Comore), Mwali (Mohéli) and Ndzouani (Anjouan), and were tested by ELISA for IgM and/or IgG antibodies to Dengue (DENV), Chikungunya (CHIKV), Rift Valley fever (RVFV), West Nile (WNV), Tick borne encephalitis (TBEV) and Yellow fever (YFV) viruses and for neutralizing antibodies to DENV serotypes 1–4. Very few sera were positive for IgM antibodies to the tested viruses indicating that the sero-survey was performed during an inter epidemic phase for the investigated arbovirus infections, except for RVF which showed evidence of recent infections on all three islands. IgG reactivity with at least one arbovirus was observed in almost 85% of tested sera, with seropositivity rates increasing with age, indicative of an intense and long lasting exposure of the Comorian population to arboviral risk. Interestingly, the positivity rates for IgG antibodies to DENV and CHIKV were significantly higher on Ngazidja, confirming the previously suggested prominent exposure of this island to these arboviruses, while serological traces of WNV infection were detected most frequently on Mwali suggesting some transmission specificities associated with this island only. The study provides the first evidence for circulation of RVFV in human populations from the Union of Comoros and further suggests that the virus is currently circulating on the three islands in an inconspicuous manner. This study supports contrasted exposure of the islands of the Comoros archipelago to arboviral infections. The observation is discussed in terms of ecological factors that may affect the abundance and distribution of vector populations on the three islands as well as concurring anthropogenic factors that may impact arbovirus transmission in this diverse island ecosystem.

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Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)

Dellagi

Salez

Maquart³

et al. 2016

PLoS Negl Trop Dis

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“…16 In general, studies have shown an increase in seroprevalence with age as a result of a longer period of exposure to the DENV circulating in endemic regions. 17,18,[35][36][37][38] In the localities of Axochiapan and Tepalcingo, the magnitude of seroprevalence detected in this study as well as the presence of dengue cases over the last 5 years situate them in the category of endemic areas in Mexico. Although the incidence is higher in Axochiapan than Tepalcingo, the difference in global seroprevalence between the localities was not statistically significant, but in the adjusted analysis by age and other variables, we observed a small difference that was statistically significant (11%, 95% CI = 5-17) and may be explained by differences in population density (Axochiapan = 0.193 habitants/km 2 ; Tepalcingo = 0.072 habitants/km 2 ).…”

Section: Discussionmentioning

confidence: 98%

Seroprevalence of Neutralizing Antibodies Against Dengue Virus in Two Localities in the State of Morelos, Mexico

Amaya-Larios¹,

Martínez-Vega²,

Mayer³

et al. 2014

The American Society of Tropical Medicine and Hygiene

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Abstract. Humoral immune response against dengue virus (DENV) is an important component in dengue-endemic transmission. We conducted a cross-sectional nested cohort study to determine the seroprevalence and frequency of neutralizing antibodies against DENV serotypes in two endemic localities in the state of Morelos, Mexico. The cohort participants (N = 1,196) were screened to determine previous exposure to DENV. Overall seroprevalence was 76.6% (95% confidence interval [95% CI] = 73.6-79.2), and prevalence of neutralizing antibodies in the 5-to 9-year-old group was 82.5% (95% CI = 67.2-92.7), 45% (95% CI = 29.3-61.5), and 65% (95% CI = 48.3-79.4) for DENV-1, DENV-2, and DENV-3, respectively. For participants older than 10 years, the observed seroprevalence was above 60% for each serotype, except DENV-4 in the 10-to 25-year-old group (42.9%); 81% of humoral responses were multitypic. The outcomes of our study contribute to understanding the immune component of dengue transmission and provide focal information for the evaluation of vaccine candidates under development.

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“…Second, we aimed to detect symptomatic illness and did not look for asymptomatic infections. Therefore, we likely underestimated the number of people infected during the outbreak given evidence that 3–25% of Chikungunya virus infections are asymptomatic [ 29 , 30 ]. Third, residents may have been unable to reliably recall their symptoms or onset of illness, particularly for milder illnesses, which may have led to an underestimation of suspected cases.…”

Section: Discussionmentioning

confidence: 99%

An Outbreak of Chikungunya in Rural Bangladesh, 2011

et al. 2015

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BackgroundThe first identified Chikungunya outbreak occurred in Bangladesh in 2008. In late October 2011, a local health official from Dohar Sub-district, Dhaka District, reported an outbreak of undiagnosed fever and joint pain. We investigated the outbreak to confirm the etiology, describe the clinical presentation, and identify associated vectors.MethodologyDuring November 2–21, 2011, we conducted house-to-house surveys to identify suspected cases, defined as any inhabitant of Char Kushai village with fever followed by joint pain in the extremities with onset since August 15, 2011. We collected blood specimens and clinical histories from self-selected suspected cases using a structured questionnaire. Blood samples were tested for IgM antibodies against Chikungunya virus. The village was divided into nine segments and we collected mosquito larvae from water containers in seven randomly selected houses in each segment. We calculated the Breteau index for the village and identified the mosquito species.ResultsThe attack rate was 29% (1105/3840) and 29% of households surveyed had at least one suspected case: 15% had ≥3. The attack rate was 38% (606/1589) in adult women and 25% in adult men (320/1287). Among the 1105 suspected case-patients, 245 self-selected for testing and 80% of those (196/245) had IgM antibodies. In addition to fever and joint pain, 76% (148/196) of confirmed cases had rash and 38%(75/196) had long-lasting joint pain. The village Breteau index was 35 per 100 and 89%(449/504) of hatched mosquitoes were Aedes albopictus.ConclusionThe evidence suggests that this outbreak was due to Chikungunya. The high attack rate suggests that the infection was new to this area, and the increased risk among adult women suggests that risk of transmission may have been higher around households. Chikungunya is an emerging infection in Bangladesh and current surveillance and prevention strategies are insufficient to mount an effective public health response.

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Seroepidemiology of Dengue Virus in Mayotte, Indian Ocean, 2006

Cited by 14 publications

References 28 publications

Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)

Serological Evidence of Contrasted Exposure to Arboviral Infections between Islands of the Union of Comoros (Indian Ocean)

Seroprevalence of Neutralizing Antibodies Against Dengue Virus in Two Localities in the State of Morelos, Mexico

An Outbreak of Chikungunya in Rural Bangladesh, 2011

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