Seroepidemiology of Epstein−Barr virus and cytomegalovirus among Israeli male young adults

Levine, Hagai; Balicer, Ran D.; Rozhavski, Vladi; Halperin, Tami; Shreberk, Michal; Davidovitch, Nadav; Huerta-Hartal, Michael; Ankol, Omer E.

doi:10.1016/j.annepidem.2012.06.099

Cited by 34 publications

(35 citation statements)

References 31 publications

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“…EBV spread requires intimate contact, and epidemiologic studies have identified the socioeconomic status and hygienic behavior as main factors for EBV acquisition . A marginally but significantly higher risk of EBV detection was reported in tonsil brushings among current tobacco smokers, in agreement with some, but not all, large seroepidemiologic studies. The risk of EBV infection study was not associated with any other studied variables including neither sex, as in most previous studies, nor indication of tonsillectomy, even though it has been suggested that EBV may play a role in the pathogenesis of recurrent tonsillitis …”

Section: Discussionsupporting

confidence: 88%

Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

Kourieh

Gheit

Tommasino

et al. 2018

Journal of Medical Virology

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Objective To assess the prevalence of all known human herpesviruses (HHV) in tonsils of an age‐stratified large sample of immunocompetent children and adults. Methods Patients undergoing tonsillectomy for benign indications were recruited in 19 French hospitals. After resection, the entire outer surfaces of right and left half tonsils were extensively brushed. A highly sensitive species‐specific multiplex assay was used to detect herpes simplex virus 1 (HSV1), HSV2, Epstein‐Barr virus (EBV; types 1 and 2), and human cytomegalovirus (CMV) DNA in 688, as well as varicella zoster virus (VZV), HHV6A, HHV6B, HHV7, and Kaposi's sarcoma‐associated herpesvirus (KSHV) DNA in a subset of 440 tonsil brushings. Results Overall 85% of tonsil brushing samples were infected with at least one HHV species. HHV7 and EBV were the most prevalent (≈70%), followed by HHV6B (≈50%), HSV1, CMV, VZV (≈2%), and KSHV and HSV2 (<1%), while HHV6A was not detected. EBV prevalence was significantly higher in adults than in children, whereas it was opposite for HHV6B and VZV. No difference in HHV prevalence was observed by sex. In multivariate analysis, EBV detection was associated with age greater than or equal to 15 years (prevalence ratio [PR] = 1.8; 95% confidence interval [CI]: 1.5‐2.3) and marginally with tobacco smoking (PR = 1.2; 95% CI: 1.1‐1.3). Conclusion Differing patterns of HHV infection in tonsils in a large age‐stratified population were described. This study is by far the largest available and shows that EBV, HHV6B, and HHV7 are commonly detected in the tonsils in both men and women, in contrast to other HHVs.

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Section: Discussionsupporting

confidence: 88%

Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

Kourieh

Gheit

Tommasino

et al. 2018

Journal of Medical Virology

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“…Similarly, a pooled analysis from the InterLymph Consortium [10] have reported a higher risk for mixed cellularity and EBV-positive HL among current cigarette smokers in both younger and older individuals and among men. Moreover, a recent survey conducted among young male adults has observed that seroprevalence of EBV was higher among current smokers (93%) than among never smokers (85%) [35]. …”

Section: Discussionmentioning

confidence: 99%

The dose-response relationship between tobacco smoking and the risk of lymphomas: a case-control study

Taborelli¹,

Montella²,

Libra³

et al. 2017

BMC Cancer

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BackgroundPrevious studies have provided limited support to the association between tobacco smoking and lymphomas with weak evidence of a dose-response relationship.MethodsWe investigated the relationship between tobacco smoking and risk of non-Hodgkin lymphomas (NHL) and Hodgkin lymphomas (HL) through logistic regression spline models. Data were derived from an Italian hospital-based case-control study (1999–2014), which enrolled 571 NHLs, 188 HLs, and 1004 cancer-free controls. Smoking habits and other lifestyle factors were assessed through a validated questionnaire. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression, adjusting for potential confounders.ResultsCompared to never smokers, people smoking ≥15 cigarettes/day showed increased risks of both NHL (OR = 1.42, 95% CI: 1.02, 1.97) and HL (OR = 2.47, 95% CI: 1.25, 4.87); the risk was particularly elevated for follicular NHL (OR = 2.43; 95% CI:1.31–4.51) and mixed cellularity HL (OR = 5.60, 95% CI: 1.31, 23.97). No excess risk emerged for former smokers or people smoking <15 cigarettes/day. Spline analyses showed a positive dose-response relationship with significant increases in NHL and HL risks starting from 15 and 21 cigarettes/day, respectively, with the most evident effects for follicular NHL and mixed cellularity HL. Smoking duration was significantly associated with the HL risk only (OR = 2.15, 95% CI: 1.16, 3.99).ConclusionsThese findings support a role of tobacco smoking in the etiology of both NHL and HL, providing evidence of a direct association of risk with smoking intensity.

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“…Using herpesviruses as a model system, we have applied the same method for defining the O-glycoproteomes of other members of Herpesviridae family-HSV-2, VZV, HCMV and EBV Iversen et al 2016). The wide occurrence, associated complications and shortage of prophylactic measures make herpesviruses a relevant model system to analyze O-glycans and their importance in viral life cycle (Vazquez et al 2001;Cohen et al 2006;Adjei et al 2008;Kramer et al 2008;Oxman 2010;Shiley and Blumberg 2010;Lopo et al 2011;Sauerbrei et al 2011;Levine et al 2012;van Rijckevorsel et al 2012;Astuto et al 2013;Conde-Glez et al 2013;Fishman 2013;Gorfinkel et al 2013;Odland et al 2013;Pembrey et al 2013;Rowe et al 2013;Awasthi and Friedman 2014;Bradley et al 2014;Fu et al 2014;Sabugo et al 2014 Shaiegan et al 2015). In addition, the large proteomes of herpesviruses highlight the benefits of global viral O-glycoproteomics.…”

Section: Global O-glycoproteomicsmentioning

confidence: 99%

Global aspects of viral glycosylation

2018

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Enveloped viruses encompass some of the most common human pathogens causing infections of different severity, ranging from no or very few symptoms to lethal disease as seen with the viral hemorrhagic fevers. All enveloped viruses possess an envelope membrane derived from the host cell, modified with often heavily glycosylated virally encoded glycoproteins important for infectivity, viral particle formation and immune evasion. While N-linked glycosylation of viral envelope proteins is well characterized with respect to location, structure and site occupancy, information on mucin-type O-glycosylation of these proteins is less comprehensive. Studies on viral glycosylation are often limited to analysis of recombinant proteins that in most cases are produced in cell lines with a glycosylation capacity different from the capacity of the host cells. The glycosylation pattern of the produced recombinant glycoproteins might therefore be different from the pattern on native viral proteins. In this review, we provide a historical perspective on analysis of viral glycosylation, and summarize known roles of glycans in the biology of enveloped human viruses. In addition, we describe how to overcome the analytical limitations by using a global approach based on mass spectrometry to identify viral O-glycosylation in virus-infected cell lysates using the complex enveloped virus herpes simplex virus type 1 as a model. We underscore that glycans often pay important contributions to overall protein structure, function and immune recognition, and that glycans represent a crucial determinant for vaccine design. High throughput analysis of glycosylation on relevant glycoprotein formulations, as well as data compilation and sharing is therefore important to identify consensus glycosylation patterns for translational applications.

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Seroepidemiology of Epstein−Barr virus and cytomegalovirus among Israeli male young adults

Cited by 34 publications

References 31 publications

Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

Prevalence of human herpesviruses infections in nonmalignant tonsils: The SPLIT study

The dose-response relationship between tobacco smoking and the risk of lymphomas: a case-control study

Global aspects of viral glycosylation

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