Seroepidemiology of Human Parvovirus B19 Infection among Pregnant Women in Abuja, Nigeria

Okojokwu, Ocheme Julius; Adebayo, Maryam Bisola; Abubakar, Bashiru Shafa; Yusuf, Ibrahim Abubakar; Anejo-Okopi, Joseph

doi:10.17582/journal.hv/2018/5.5.57.62

Cited by 2 publications

(5 citation statements)

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“…The findings of this present study revealed 44.3% B19V IgG prevalence and 41.8% B19V IgM prevalence among the study population. The prevalence as indicated by B19V IgG is similar to the 41.5% reported in Northern Nigeria (Jegede et al, 2014), 52.5% reported in North Central Nigeria (Okojokwu et al, 2018) and 55% reported in Tanzania (Mirambo et al, 2017) but higher than 20% (Abiodun et al, 2013) reported in Southwest Nigeria. The increased prevalence from Southwest Nigeria could be related to time lag since the research was conducted about 10 years ago.…”

Section: Discussionsupporting

confidence: 81%

“…Their odds ratio suggests that women who had suffered miscarriage and still birth had greater than two times likelihood of have been exposed to B19V infection. This finding deferred from the report of Okojokwu et al (2018), who reported no association between miscarriage, still birth and prevalence of B19V. This is probably due to sociocultural variations between the two study locations.…”

Section: Discussioncontrasting

confidence: 70%

“…Similar to the findings in North central Nigeria (Emiasegen et al, 2011;Okojokwu et al, 2018), the highest prevalence was recorded among the age group >36 years but contrary to their report, prevalence of IgM was also highest in the lower age group in this study. The reason for this may not be unconnected to cultural and behavioral diversity in different locations of the country.…”

Section: Discussionsupporting

confidence: 70%

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PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.

Akele¹,

Abelekum²,

Oluboyo³

et al. 2021

AJID

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Background: Human Parvovirus B19 (B19V) is a DNA virus, transmitted through respiratory secretions, hand-to-mouth-contact, blood transfusion and trans-placental transfer. It causes high mortality and morbidity in pregnant women, thus contributing to poor maternal and child health. B19V has been neglected due to dearth of epidemiological data. The aim of this study was to determine the sero-prevalence of Human Parvovirus B19 antibodies among pregnant women attending antenatal clinic at Federal Teaching Hospital Ido-Ekiti, Nigeria. Materials and Methods: This cross-sectional study enrolled pregnant women attending Federal Teaching Hospital Ido-Ekiti from January to May 2019 to obtain sero-epidemiological data. One hundred and twenty-two (122) consenting pregnant women were enrolled following institutional ethical approval. They were administered structured questionnaire and venous blood was collected in plain tubes for serum extraction. Sera samples were analyzed for IgG and IgM antibodies using the enzyme linked immunosorbent assay method. Percentages, median, chi-square and multivariate analysis were carried out using SPSS version 17. Results: The prevalence of IgG was 44.3% (54/122), IgM 41.8% (51/122), and IgG/IgM 28.7% (35/122) leaving 55.7% (68/122) of the population uninfected. The median age of participants was 22 (Interquartile range 18-25) years among which 36-45years had the highest prevalence which was not statistically significant (p=0.09 4.75). There was association between miscarriage, still birth, history of blood transfusion and prevalence of Human Parvovirus B19 (p<0.05). Conclusion: There is a high Prevalence of B19V among pregnant women attending antenatal clinic in this study. This underscores the need for testing and immunization of pregnant women against B19V.

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Section: Discussionsupporting

confidence: 81%

Section: Discussioncontrasting

confidence: 70%

Section: Discussionsupporting

confidence: 70%

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PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.

Akele¹,

Abelekum²,

Oluboyo³

et al. 2021

AJID

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“…The prevalence of IgG among pregnant women in Benin (67.4%) is similar to that found in other African countries such as Libya, Sudan and Tanzania [16, 23, 35], but is higher than those reported in some studies of a confining country such as Nigeria with values ranging from 20% to 50% depending on the area studied [25, 31–33, 38, 39, 41]. We saw no significant variations in IgG prevalence with age.…”

Section: Discussionsupporting

confidence: 85%

“…Although an increase in prevalence with age is described in the literature [7], it is also reported that in African pregnant women, there is no such difference as they have already encountered the infection before reaching the age of conception [23, 25, 34]. We also found no difference between trimesters of pregnancy (there are conflicting data in the literature [32, 34, 35]), nor in relation to cases of abortion [34, 41]. Instead, we found a significant difference in relation to occupation, with a higher prevalence among housewives than other occupations, as previously reported [31–33].…”

Section: Discussionsupporting

confidence: 81%

Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

Paschale

Ceriani

Cerulli³

et al. 2023

Tropical Med Int Health

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Objectives: Parvovirus B19 (B19V) infection in pregnancy is generally asymptomatic, but in about 3% it can cause complications, including miscarriage, severe foetal anaemia and foetal hydrops. The seroprevalence in pregnancy ranges from 20% to 82% in Africa, but there are no data for Benin. We therefore retrospectively assessed the seroprevalence of B19V in pregnant women attending the Saint Jean de Dieu Hospital in Tanguiéta, a rural district of Atacora, in northern Benin. Methods: We searched for anti-B19V immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies in 227 sequential sera from as many women (mean age 26.3 years, range: 16-41) of whom 30 were in the first trimester, 66 in the second and 131 in the third. Samples that tested positive for IgM were analysed with an immunoblot test and the viral genome (DNA-B19V) was searched for using a polymerase chain reaction. Results: Of the 227 women, 153 (67.4%) were positive for IgG anti-B19V, 7 (3.1%) for IgM and 73 (32.2%) were non-immune. Six IgM-positive women were also IgG positive. The difference in IgG seroprevalence between trimesters or ages was not statistically significant. Of the seven IgM-positive samples, three were confirmed positive by immunoblot (of which two were DNA-B19V positive), three were indeterminate (DNA-B19V negative) and one was negative (DNA-B19V negative). Of the three women with confirmed positive IgM, two were in the third trimester and one in the second trimester of pregnancy. Conclusions: The seroprevalence of anti-B19V IgG among pregnant women in Benin is high and in line with those reported in some African countries. IgM seroprevalence is also similar to that described in some African countries in non-epidemic periods. The low viral load observed depicts non-acute infections, but it is difficult to establish the precise time of the infection, especially for women tested in the second or third trimester of pregnancy, when the observed viremia could be a sign of an acute infection that occurred in the previous trimester. Consequently, clinical follow-up and further investigations to highlight possible foetal consequences are indicated.

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Seroepidemiology of Human Parvovirus B19 Infection among Pregnant Women in Abuja, Nigeria

Cited by 2 publications

References 0 publications

PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.

PREVALENCE OF HUMAN PARVOVIRUS B19 IgG AND IgM ANTIBODIES AMONG PREGNANT WOMEN ATTENDING ANTENATAL CLINIC AT FEDERAL TEACHING HOSPITAL IDO-EKITI, NIGERIA.

Prevalence of parvovirus B19 antibodies in pregnant women in northern Benin

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