Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango, Mexico

Alvarado‐Esquivel, Cosme; Mercado-Suárez, Miguel Francisco; Rodríguez-Briones, Alfredo; Fallad-Torres, Laura; Ayala-Ayala, Julio Octavio; Nevarez-Piedra, Luis Jorge; Duran-Morales, Ehecatl; Estrada-Martínez, Sergio; Liesenfeld, Oliver; Márquez-Conde, José Ángel; Martínez‐García, Sergio

doi:10.1186/1471-2334-7-75

Cited by 74 publications

(78 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…High seroprevalence of T. gondii with age detected in this study is consistent with other studies conducted on this subject [11,[17][18]. The increase in risk of acquiring Toxoplasma for elder people may be due to a longer lifetime exposure of these people to Toxoplasma-contaminated environmental sources.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Seroprevalence and molecular diagnosis of Toxoplasma gondii infection among blood donors in southern Iran

Sarkari

Salehi

Zare

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Toxoplasma gondii is a protozoan parasite which can be transmitted to human through a variety of routes including blood transfusion. This cross sectional study aimed to evaluate the seroprevalence of Toxoplasma infection and related epidemiological features among healthy blood donors. Methodology: A total of 1,480 healthy blood donors from five blood service centers in Fars province were analyzed for anti-Toxoplasma antibodies. Blood samples were tested for anti-T. gondii IgG and IgM antibodies by enzyme immunoassay. IgM-positive samples were also tested for the presence of Toxoplasma DNA by Polymerase Chain Reaction (PCR). Demographic characteristics of participants were also recorded during samples collection. Results: Anti T. gondii antibodies were detected in sera of 286 out of 1,480 blood donors corresponding to an overall seroprevalence of 19.3% in this population. From these, 182 (12.3%) were seropositive only for IgG, 81 (5.47%) were seropositive only for IgM and 23 (1.6%) were positive for both IgG and IgM. PCR detected active parasitemia in two (1.9%) of the IgM-positive subjects. Age, place of residence and level of education were statistically significant (p < 0.05) with seropositivity to Toxoplasma. Conclusions: Our results highlighted that asymptomatic blood donors, especially those with active parasitemia, may constitute a significant risk of transmitting toxoplasmosis to susceptible recipients.

show abstract

Section: Discussionsupporting

confidence: 92%

“…In some areas, such as northeast Brazil, north India and Egypt, more than 50% of blood donors have been seropositive for Toxoplasma infection [11,14,16]. Lower rate of infection in blood donors have been reported from Taiwan (9.3%), Thailand (9.6%), Mexico (7.4%) or Turkey (19.5%) [10,15,[17][18].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and molecular diagnosis of Toxoplasma gondii infection among blood donors in southern Iran

Sarkari

Salehi

Zare

et al. 2014

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…These variations in the seroprevalence of anti-T. gondii antibodies among childbearing age women in different parts of Iran might be related to geographical and environmental factors, and transmission routes in the studied population, sampling method, types of laboratory tests and tools, cut off point for positive test (positive test definition), etc. (Alvarado-Esquivel et al 2007;Haghdoost et al 2007). The obtained results exhibited that both contact with cats and consumption of raw/half-cocked meat are significant risk factors for T. gondii seropositivity, which indicated that, among childbearing age women in this study, both infection routes, the ingestion of oocysts (animal to human transmission) and that of tissue cysts in meat (food-borne transmission), existed, similar to the infection routes reported in other studies (Khazaei et al 2012).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

et al. 2015

View full text Add to dashboard Cite

This cross-sectional study aims to determine the prevalence of IgM and IgG anti-T. gondii antibodies and the associated risk factors among childbearing age women referring to counseling centers before marriage in Kerman city, southeast of Iran. Totally, 300 serum samples were collected from women referred to Central Laboratory for Marriage Consultation in Kerman city were screened for IgG and IgM anti-T. gondii antibodies by enzyme linked immunosorbent assay (ELISA). Out of the 300 serum samples, 38 (12.6 %) tested seropositive for anti-T. gondii antibodies; 31 (10.3 %) samples tested seropositive for only IgG antibody, 1 (0.33 %) tested seropositive for both IgM and IgG and 6 (2.0 %) were positive for IgM antibody alone. Statistical analyses also indicated that seroprevalence of anti-T. gondii antibodies increased with age (p \ 0.05). Moreover, some risk factors such as, living in rural regions, contact with cats, raw/half-cooked meat consumption, and agricultural activities were significantly (p \ 0.05) related to T. gondii seropositivity. The findings revealed that more than three-quarters of the childbearing age women studied in the present investigation are susceptible to infection during pregnancy. Thus, by adopting correct and improved practices we can improve their living conditions, and prevent infection and awareness and control of pathogens associated with disease is recommended.

show abstract

“…In this investigation, it was found that contact with cats, consumption of raw vegetables, raw-milk/egg consumption, and drinking clean water (as potential risk factors for acquiring toxoplasmosis) were associated with the seropositivity of T. gondii (2,44). However, no difference was found between education, raw-milk/egg consumption, and blood transfusion on the one hand seroprevalence of anti-T. gondii antibodies on the other.…”

Section: Discussionmentioning

confidence: 67%

Possible Link Between Toxoplasma gondii Infection and Mood Disorders in Lorestan Province, Western Iran

Kheirandish

Nazari

Mahmoudvand

et al. 2016

Arch Clin Infect Dis

View full text Add to dashboard Cite

Background: A large number of epidemiological evidence in humans and experimental studies in rodents have hypothesized that Toxoplasma gondii is a potentially relevant etiological factor in some mood disorders. Objectives: The aim of this study was to investigate whether latent toxoplasmosis has any role in mood disorders such as schizophrenia and bipolar disease in Western Iran. Patients and Methods: A total of 170 patients including 85 schizophrenia and 85 bipolar patients referred to the only psychiatric hospital in Lorestan province in Khorramabd city, Western Iran, and 170 healthy volunteers were screened for IgG and IgM anti-T. gondii antibodies by the Enzyme Linked Immunosorbent Assay (ELISA). Structured questionnaires were used to obtain information on risk factors for T. gondii infection. Results: Out of the 170 psychiatric patients, 103 (63.5%) patients were seropositive for IgG antibody and 14 (8.2%) were seropositive for IgM antibody. Of the 85 bipolar patients, 54 (63.5%) and 6 (7%) were found positive for anti-T. gondii IgG and IgM antibodies, respectively; whereas among 85 schizophrenia patients, 49 (57.6%) and 8 (9.4%) samples were found positive for anti-T. gondii IgG and IgM antibodies, respectively. From 170 healthy volunteers, 73 (42.9%) tested seropositive for anti-T. gondii antibodies; 65 (38.2%) tested seropositive for IgG antibody and 8 (4.7%) tested seropositive for IgM antibody. There was a significant difference in T. gondii IgG positivity between the psychiatric patients and control groups (P = 0.009). Several risk factors, which were significantly related to T. gondii seropositivity in psychiatric patients are being in contact with cats (P = 0.004), eating unwashed raw vegetables (P < 0.001), raw-milk/egg consumption (P = 0.001), and drinking clean water (P = 0.035). Conclusions: We concluded that psychiatric patients in general and schizophrenia and bipolar cases in particular had a significantly higher relative frequency of T. gondii infection than healthy individuals of Lorestan Province, Western Iran.

show abstract

Seroepidemiology of infection with Toxoplasma gondii in healthy blood donors of Durango, Mexico

Cited by 74 publications

References 21 publications

Seroprevalence and molecular diagnosis of Toxoplasma gondii infection among blood donors in southern Iran

Seroprevalence and molecular diagnosis of Toxoplasma gondii infection among blood donors in southern Iran

Seroprevalence of Toxoplasma gondii infection among childbearing age women in Kerman city, southeastern Iran

Possible Link Between Toxoplasma gondii Infection and Mood Disorders in Lorestan Province, Western Iran

Contact Info

Product

Resources

About