Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Reinheimer, Claudia; Allwinn, Regina; Wittek, Miriam

doi:10.1007/s15010-010-0035-y

Cited by 17 publications

(16 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furthermore, our groups were matched by age and sex. This, in turn, excludes the bias, which is made by a higher seropositivity to anti-HEV-IgG in elder patients: as previously documented for several infectious diseases [38,39], rate of seropositivity to anti-HEV-IgG is also increasing by age [40,41] and Fig. 2.…”

Section: Discussionmentioning

confidence: 68%

Hepatitis E: are psychiatric patients on special risk?

Reinheimer

Allwinn

Berger

2011

Med Microbiol Immunol

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is largely confined to travelers returning from endemic areas, but the number of autochthonous cases of acute HEV infections in developed countries is increasing. Reservoirs for HEV are surface water, wild boar meat, and raw or undercooked pork meat. Usually, hepatitis E is a self-limiting disease presenting with acute hepatitis as a major clinical symptom. The seroprevalence of anti-HEV-IgG was investigated in 833 serum samples routinely collected from patients admitted to the university hospital in Frankfurt a. M., Germany (FFM) between 01.06.2008 and 31.12.2010. After determination of overall seroprevalence, we tested serum samples from patients diagnosed with acute elevation of liver enzymes (AELE), psychiatric (PSYCH), infectiological patients and serum samples from the red-cross blood donor service in FFM for anti-HEV-IgG using an ELISA. Between 01.06.2008 and 31.12.2010, 833 serum samples were analyzed for anti-HEV-IgG using an ELISA. We observed an overall seroprevalence of anti-HEV-IgG of 11.2% (95%CI: 9.6-13.2). Significantly higher rate of seropositivity was found in the group of PSYCH (26.0%; 95%CI: 14.63-40.34) and AELE (30.0%; 95%CI: 17.86-44.61). Overall seroprevalence of anti-HEV-IgG in FFM is higher than in Germany on average. The group of AELE and PSYCH shows significantly more often marker of HEV infections than other groups in our collective.

show abstract

Section: Discussionmentioning

confidence: 68%

Hepatitis E: are psychiatric patients on special risk?

Reinheimer

Allwinn

Berger

2011

Med Microbiol Immunol

View full text Add to dashboard Cite

show abstract

“…B19V seroprevalence among patients with sickle cell disease patients increased with age, beginning with low rates in children (20.7%) to almost complete seropositivity in patients aged >40 years (93.3%). Although this epidemiologic distribution reflects the immune response to B19V [Reinheimer et al, 2010], it nevertheless demonstrates increased viral circulation among elderly patients with sickle cell disease. In contrast, in blood donors, the highest seroprevalence was detected in individuals aged 18–29 years (65.6%), whereas in donors aged 30–39 and >40 years it was similar and reached a plateau.…”

Section: Discussionmentioning

confidence: 99%

Molecular and phylogenetic analyses of human Parvovirus B19 isolated from Brazilian patients with sickle cell disease and β‐thalassemia major and healthy blood donors

Slavov

Haddad

Silva-Pinto

et al. 2012

Journal of Medical Virology

View full text Add to dashboard Cite

Human Parvovirus B19 (B19V) is a recognized cause of life-threatening conditions among patients with hemoglobinopathies. This study investigates B19V infection in patients with sickle cell disease and β-thalassemia using different experimental approaches. A total of 183 individuals (144 with sickle cell disease and 39 with β-thalassemia major) and 100 healthy blood donors were examined for B19V using anti-B19V IgG enzyme immunoassay, quantitative PCR, DNA sequencing, and phylogenetic analysis. Viremia was documented in 18.6% of patients and 1% of donors, and was generally characterized by low viral load (VL); however, acute infections were also observed. Anti-B19V IgG was detected in 65.9% of patients with sickle cell disease and in 60% of donors, whereas the patients with thalassemia exhibited relatively low seroreactivity. The seroprevalence varied among the different age groups. In patients, it progressively increased with age, whereas in donors it reached a plateau. Based on partial NS1 fragments, all isolates detected were classified as subgenotype 1A with a tendency to elicit genetically complex infections. Interestingly, quasispecies occurred in the plasma of not only patients but also donors with even higher heterogeneity. The partial NS1 sequence examined did not exhibit positive selection. Quantitation of B19V with a conservative probe is a technically and practically useful approach. The extensive spread of B19V subgenotype 1A in patients and donors and its recent introduction into the countryside of the São Paulo State, Brazil were demonstrated; however, it is difficult to establish a relationship between viral sequences and the clinical outcomes of the infection.

show abstract

“…70 % der Frauen im gebärfähigen Alter weisen schützende AK auf als Folge einer früher durchgemachten manifesten oder subklinischen Infektion [9]. Die übrigen Frauen sind gefährdet.…”

Section: Ringelröteln Krankheitsbild Und Epidemiologieunclassified

“…Der quantitative IgG-Test dient auch zur Beurteilung der PV B19spezifischen AK im Immunglobulin für die passive Immunisierung. Die Bestimmung infektionsneutralisierender AK steht nicht zur Verfügung, weil das PV B19 in speziellen Zellkulturen nur schwer züchtbar ist [8,9,10].…”

Section: Serumantikörper-bestimmung Bei Ringelrötelnunclassified

Windpocken/Gürtelrose und Ringelröteln: Ist eine routinemäßige Antikörpertestung sinnvoll?

Doerr¹

2015

Hebamme

View full text Add to dashboard Cite

Neben den Hautzellen werden auchZellen des sensorischen Nervensystems infiziert [3]. In den Zellkernen in den paravertebralen Hinterwurzel-Ganglien am Rückenmark verbleibt die Virus-DNA lebenslang. Es handelt sich um eine latente (nicht Virus produzierende) Persistenz unter der Kontrolle von Zytokinen der erregerspezifischen T-Lymphozyten. Die Immunreaktion wird mit dem Exanthem in Gang gesetzt. Neben den T-Lymphozyten werden auch B-Lymphozyten gebildet, welche, zu Plasmazellen umgewandelt, die Antikörper (AK) gegen das VZV produzieren. Die Serum-AK bleiben lebenslang leicht nachweisbar, da ihre Produktion von undulierenden Infekt-Reaktivierungen stimuliert wird. Dr. H. W. Doerr, Frankfurt a.M. Doerr, Windpocken/Gürtelrose und Ringelröteln: Ist eine routinemäßige Antikörpertestung sinnvoll? | Die Hebamme 2015; 28: 98-101

show abstract

Seroepidemiology of parvovirus B19 in the Frankfurt am Main area, Germany: evaluation of risk factors

Cited by 17 publications

References 26 publications

Hepatitis E: are psychiatric patients on special risk?

Hepatitis E: are psychiatric patients on special risk?

Molecular and phylogenetic analyses of human Parvovirus B19 isolated from Brazilian patients with sickle cell disease and β‐thalassemia major and healthy blood donors

Windpocken/Gürtelrose und Ringelröteln: Ist eine routinemäßige Antikörpertestung sinnvoll?

Contact Info

Product

Resources

About