Seroepidemiology of pertussis in the east of China: Estimates of incidence of infection in adolescents and adults pre- and post-COVID-19

Chen, Qiang; Wang, Wen; Shi, Xiuyun; Xu, Yongjian; Zhu, Yanhong; Wang, Yun; Wang, Zhiguo; Sun, Hui; Sun, Xiang

doi:10.3389/fpubh.2022.1054617

Cited by 10 publications

(8 citation statements)

References 32 publications

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“…Similar situations were observed in other regions, with estimated pertussis infection rates as follows: 7290/100,000 in Chongqing [ 19 ], 4573/100,000 in Ningbo [ 7 ], 9395/100,000 in Guangdong [ 25 ], 18080/100,000 in Jiangsu [ 17 ], and 6600/100,000 in the Netherlands [ 4 ]. Meanwhile, this study revealed a high susceptibility rate of 40.49% for individuals with Anti-PT-lgG <5 IU/mL, consistent with findings from multiple studies [ 17 , 18 , 28 ]. This indicates a coexistence of high infection rates and susceptibility in the population.…”

Section: Discussionsupporting

confidence: 72%

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Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Liu,

Zhang,

Wang

et al. 2024

PLoS ONE

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Purpose The resurgence of pertussis has occurred around the world. However, the epidemiological profiles of pertussis cannot be well understood by current diseases surveillance. This study was designed to understand the seroepidemiological characteristics of pertussis infection in the general population of Huzhou City, evaluate the prevalence infection of pertussis in the population, and offer insights to inform adjustments in pertussis prevention and control strategies. Methods From September to October 2023, a cross-sectional serosurvey was conducted in Huzhou City, involving 1015 permanent residents. Serum samples were collected from the study subjects, and pertussis toxin IgG antibodies (Anti-PT-IgG) were quantitatively measured using enzyme-linked immunosorbent assay (ELISA). The analysis included the geometric mean concentration (GMC) of Anti-PT-IgG, rates of GMC≥40IU/mL, ≥100IU/mL, and <5IU/mL. Stratified comparisons were made based on age, vaccination history, and human categories. Results Among the 1015 surveyed individuals, the geometric mean concentration (GMC) of Anti-PT-IgG was 10.52 (95% CI: 9.96–11.11) IU/mL, with a recent infection rate of 1.58%, a serum positivity rate of 11.43%, and a proportion with <5IU/mL of 40.49%. Among 357 children with clear vaccination history, susceptibility decreased with an increasing number of vaccine doses (Z = -6.793, P < 0.001). The concentration of Anti-PT-IgG exhibited a significant post-vaccination decline over time (Z = -5.143, P < 0.001). In women of childbearing age, the GMC of Anti-PT-IgG was 7.71 (95% CI: 6.90–8.62) IU/mL, with no significant difference in susceptibility among different age groups (χ2 = 0.545, P = 0.909). The annual pertussis infection rate in individuals aged ≥3 years was 9321 (95%CI: 3336–16039) per 100,000, with peak infection rates in the 20–29, 40–49, and 5–9 age groups at 34363 (95%CI: 6327–66918) per 100,000, 22307.72 (95%CI: 1380–47442) per 100,000, and 18020(95%CI: 1093–37266) per 100,000, respectively. Conclusions In 2023, the actual pertussis infection rate in the population of Huzhou City was relatively high. Vaccine-induced antibodies exhibit a rapid decay, and the estimated serum infection rate increases rapidly from post-school age, peaking in the 20–29 age group. It is recommended to enhance pertussis monitoring in adolescents and adults and refine vaccine immunization strategies.

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Section: Discussionsupporting

confidence: 72%

“…Current serological studies on pertussis often focus on hospital case populations [15] or specific groups [16]. with significant variations in seroprevalence across different regions [7,[17][18][19]. This study, conducted in Huzhou, China, represents a cross-sectional survey of pertussis toxin antibody levels in a healthy population.…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Liu,

Zhang,

Wang

et al. 2024

PLoS ONE

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“…The individual’s immunity to pertussis gradually weakens with age, a phenomenon that has been demonstrated in a number of studies. 17 , 25 , 26 In the present study, we evaluated the levels of serum anti-PT IgG antibodies among healthy health care workers aged between 20 to 59 years. In the four age groups, the GMCs of anti-PT IgG in the higher age groups were higher than those in the lower age groups.…”

Section: Discussionmentioning

confidence: 99%

“… Age (years) No. Region GMC ELISA kits Reference 20–29 266 Wuhu 4.56 (2.76–6.36) Euroimmun This study 356 Zhejiang 3.99 (3.59–4.44) Whuan Institute 27 252 Beijing 4.28 (3.82–4.81) Virion/Serion 30 * 327 3.78 (3.38–4.22) 347 3.31 (3.00–3.65) 457 Beijing 8.12 (7.45–8.84) Virion/Serion 25 223 Jiangsu 15.50 (12.48–18.52) Virion/Serion 26 30–39 407 Wuhu 4.83 (3.84–5.82) Euroimmun This study …”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of tetanus and pertussis antibodies among health care workers in Wuhu, China

Shi,

Wang,

Meng

et al. 2024

Human Vaccines & Immunotherapeutics

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This study aimed to elucidate the seroprevalence of antibodies to tetanus and pertussis among Chinese health care workers. Blood specimens from health care workers were collected during the 2021 annual medical examination at the First People’s Hospital of Wuhu. Commercial ELISA kits were employed to quantify serum IgG antibodies against tetanus toxin (anti-TT IgG) and both IgG and IgA antibodies against pertussis toxin (anti-PT IgG, anti-PT IgA). A concentration of anti-TT IgG exceeding 0.1 IU/ml was deemed seroprotective against tetanus, while concentrations of anti-PT IgG ≥ 50 IU/ml or anti-PT IgA ≥ 15 IU/ml were indicative of a prior pertussis infection. The overall seroprotective rate for anti-TT IgG stood at 10.43% (92/882), with the highest seroprotective rate (13.91%) in the 20–29 age group, followed by the 30–39 age group (10.57%), 40–49 age group (5.80%), and 50–59 age group (5.63%). Eighteen (2.04%) of the studied subjects were positive to anti-PT IgG, and the positive rate in 20–39 age group and 40–59 age group was 1.19% (8/673) and 4.78% (10/209), respectively. Thirty (3.40%) subjects displayed anti-PT IgG levels ≥100 IU/ml and/or anti-PT IgA ≥ 15 IU/ml, suggesting a recent pertussis infection within the preceding year. Over half (503/882, 57.03%) had undetectable anti-PT IgG antibodies. The majority of health care workers in China appear susceptible to tetanus and pertussis, and a significant subset has experienced pertussis infection. The implementation of booster vaccinations against these diseases for Chinese health care workers is recommended.

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“…19 International Journal of General Medicine 2023:16 Before and after the COVID-19 pandemic, there was a high rate of under-reporting of pertussis in Jiangsu province and a large number of reproductive-age adults who were susceptible to pertussis. 24 Six to nine months after discharge, 25% of recovered COVID-19 patients in Beijing showed pulmonary ventilation dysfunction, and 35.9% showed diffusion dysfunction; 56.5% of severe cases had reduced lung diffusion capacity. Chest CT results showed nodules in 55.36% of cases, strip-like changes in 44.64% of cases, ground-glass opacity in 37.5% of cases, and grid shadow in 5.36% of cases, with statistically significant differences between severe and non-severe groups.…”

Section: Covidmentioning

confidence: 95%

Recent Advancements on Long COVID in China: A Narrative Review

Tang¹,

Song²,

Kuang³

et al. 2023

IJGM

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The COVID-19 pandemic is a huge public health crisis in the 21st century. In addition to the acute symptoms, a considerable proportion of patients worldwide have suffered from post-COVID-19 syndrome, commonly known as Long COVID. The impact of Long COVID on individual and public health burden cannot be ignored. According to recent researches, Long COVID has been affecting multiple organ systems throughout the body, with respiratory, mental, nervous and digestive symptoms often seen in Chinese population. Clinical studies have proved that symptoms were alleviated by a variety of treatments, such as physical therapy, rehabilitation training, psychological support, behavioral cognitive therapy, stem cell therapy, etc. Based on the current clinical evidence, it is recommended to strengthen the scientific research on Long COVID and actively carry out early monitoring and intervention in the future, so as to effectively prevent the long-term disease burden and economic pressure.

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Seroepidemiology of pertussis in the east of China: Estimates of incidence of infection in adolescents and adults pre- and post-COVID-19

Cited by 10 publications

References 32 publications

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Seroepidemiology of pertussis in Huzhou: A population-based, cross-sectional study

Seroprevalence of tetanus and pertussis antibodies among health care workers in Wuhu, China

Recent Advancements on Long COVID in China: A Narrative Review

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