Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

Ristić, Mioljub; Vuković, Vladimir; Patić, Aleksandra; Marković, Miloš; Petrović, Vladimir

doi:10.3390/vaccines10122168

Cited by 5 publications

(2 citation statements)

References 31 publications

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“…A study from Belgium reported seroprevalence of 15.1% before vaccination (December 2020) and an increase to 84.2% after the first vaccination among primary healthcare providers, underlining the importance of vaccination for occupational health and protection of medical personnel (21). Recently, a study from Serbia, similar to ours, reported 93.0% overall prevalence of anti-SARS-CoV-2 antibodies among HCWs before the emergence of the Omicron variant (22). In general, the seropositivity levels have increased since the first and second waves of COVID-19 and after the mass vaccination.…”

Section: Discussionsupporting

confidence: 72%

Sars-Cov-2 Serosurvey Among Bulgarian Healthcare Workers Before and After Vaccination

Trifonova

Ngoc

Gladnishka

et al. 2023

Probl Infect Parasit Dis

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Background: In the response to the current COVID-19 pandemic caused by the novel SARS-CoV-2, one of the groups at higher risk were healthcare workers (HCWs), especially those who worked on the frontline. The presence of SARS-CoV-2 specific IgG antibodies (seropositivity) in certain populations provides better understanding of virus circulation and transmission. Our aim was to study the seroprevalence rates of anti-SARS-CoV-2 antibodies among a group of healthcare workers before and after vaccination/COVID-19 infection. Material and Methods: We determined the presence of SARS-CoV-2 specific IgG and IgA antibodies against S-antigen of by ELISA method. In this study, we enrolled 74 healthcare workers and three months later, 48 of the participants were followed up. At the baseline, none of the participants was vaccinated or had suffered COVID-19. Results: SARS-Cov-2 specific IgG antibodies were found in 32.4% of the participants. Higher prevalence of class IgA antibodies – 44.6% was detected. All samples that were IgG seropositive were also positive or borderline for IgA antibodies. Overall, virus-specific antibodies were not detected in 40.6% of HCWs in the group. During the follow-up (after vaccination and/or COVID-19 infection) high rates of both IgG and IgA seroprevalence were established. SARS-C0V-2 specific IgG antibodies were detected in 95.8% of the participants. Statistically significant difference was found in the levels of IgG and IgA antibodies both before and after vaccination, p<0.0001. Conclusions: Based on detection of anti-SARS-CoV-2 IgG antibodies, seroprevalence of 32.4% was established in an unvaccinated group of HCWs. Our survey demonstrated that asymptomatic COVID-19 infection may induce weaker humoral immune response, with production of IgA but not of IgG antibodies.

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Section: Discussionsupporting

confidence: 72%

Sars-Cov-2 Serosurvey Among Bulgarian Healthcare Workers Before and After Vaccination

Trifonova

Ngoc

Gladnishka

et al. 2023

Probl Infect Parasit Dis

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“…As the availability of Ag-RDT tests increased in Serbia, the testing algorithm was expanded so that other clinical forms became more present throughout the subsequent waves, depending on the dominant strain that was circulating. In a subsequent study that focused on health workers in state health centers (6936 participants out of 27,738 of all employees in Vojvodina), comparing the clinical manifestations they had the last time they were SARS-CoV-2 positive with their vaccination status, it was found that the highest seroprevalence of SARS-CoV-2 antibodies had asymptomatic (64.36%), mild (45.17%), severe (38.39%), and critical (45.45%) forms that received three doses of the vaccine [57].…”

Section: Discussionmentioning

confidence: 99%

Epidemiological Characteristics of COVID-19 during Seven Consecutive Epidemiological Waves (2020–2022) in the North Bačka District, Serbia

Banjac,

Vuković,

Pustahija

et al. 2023

Viruses

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The COVID-19 pandemic continues to pose a threat to global public health. The purpose of this research was to determine the epidemiological characteristics of COVID-19 in the North Bačka district while observing seven pandemic waves. The cross-sectional study was based on data from the COVID-19 surveillance database of the Institute for Public Health of Vojvodina during the period from March 2020 to December 2022. A total of 38,685 primary infections and 4067 reinfections caused by SARS-CoV-2 were notified. Pandemic waves caused by the Delta variant (cumulative incidence rate of 2482.37/100,000) and by the Omicron variant (cumulative incidence rate of 2994.45/100,000) emerged as significant focal points during the surveillance period. Over the course of three consecutive years (2020–2022), women were more affected (50.11%, 54.03%, and 55.68%, respectively). The highest incidence rates in age-specific categories were recorded in 2021 for the age group 40–49 (1345.32 per 10,000 inhabitants), while in 2022, they shifted towards the elderly population. Regarding vaccination status at the time of diagnosis, in 2021, around 15% of patients were vaccinated, while in 2022, the number increased to 37%. The most widely received vaccine was BBIBP-CorV (67.45%), followed by BNT162b2 (19.81%), Gam-COVID-Vac (9.31%), and ChAdOx1 nCoV-19 (3.42%) vaccine. The implementation of stringent public health measures and their mitigation, together with the emergence of new variants, influenced the dynamics of COVID-19 pandemic waves in the North Bačka district. Notably, throughout the study period, the working-age population was the most affected, along with females, with a mild clinical presentation dominating. Reinfections were most frequently recorded during the latter pandemic waves. Dealing with this pandemic has provided some valuable lessons for the development of future strategies in the case of a similar public health crisis.

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A study of anti-SARS-CoV-2 antibodies among healthcare personnel and the general population

Trifonova,

Ngoc,

Gladnishka

et al. 2023

Biotechnology & Biotechnological Equipment

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Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

Cited by 5 publications

References 31 publications

Sars-Cov-2 Serosurvey Among Bulgarian Healthcare Workers Before and After Vaccination

Sars-Cov-2 Serosurvey Among Bulgarian Healthcare Workers Before and After Vaccination

Epidemiological Characteristics of COVID-19 during Seven Consecutive Epidemiological Waves (2020–2022) in the North Bačka District, Serbia

A study of anti-SARS-CoV-2 antibodies among healthcare personnel and the general population

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