Seroepidemiology of the Human T-Cell Leukaemia/Lymphoma Viruses in Europe

doi:10.1097/00042560-199609000-00010

Cited by 20 publications

(1 citation statement)

References 36 publications

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“…Furthermore, similar reports have been in Spain (three cases) and Venezuela (390 cases out of 100,000) (16). It has been reported that migration from endemic areas is the leading cause of virus transmission to non-endemic areas (17)(18)(19). In Spain, screening for the virus has been mandatory for organ donors from endemic or high-risk areas since 2005 (20).…”

Section: Introductionsupporting

confidence: 52%

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

Nasri

Fakhim

Jafari-Sales

et al. 2022

Arch Clin Infect Dis

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Objectives: This study aimed to assess the prevalence of human T-lymphotropic virus type 1 (HTLV-1) among brain-dead organ donors at Masih Daneshvari Hospital in Tehran, Iran. Methods: By enzyme-linked immunosorbent assay (ELISA), 54 organ donors were screened for HTLV-1 virus in this descriptive cross-sectional study. Following that, Western blot confirmation was performed to confirm the HTLV-I infection. Results: Anti-HTLV-1 antibodies were detected in 2 (3.4%) cases out of 54 patients tested by ELISA. A western blot was performed in cases of positive results, but none of the subjects tested positive for HTLV-1 infection. Conclusions: The results of the present study indicated rare cases of HTLV-I infection in brain-dead organ donors. However, it is recommended that organ donors be investigated for the prevalence of this virus.

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Section: Introductionsupporting

confidence: 52%

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

Nasri

Fakhim

Jafari-Sales

et al. 2022

Arch Clin Infect Dis

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Human T-cell lymphotropic virus infection in pregnant women in Spain

Tuset

Gutiérrez

Carbonell

et al. 1997

Eur. J. Clin. Microbiol. Infect. Dis.

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Unique morphological alterations of the HTLV-I transformed C8166 cells by infection with HIV-1

Ongrádi

Laird

Szilágyi

et al. 2000

Pathol. Oncol. Res.

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C8166 cells express T lymphocyte markers, a monocyte-specific esterase, taxpolypeptide of HTLV-I. In spite of this transactivator, their HIV-1 yield is low. Their culture conditions were modified, and infected cells were immobilized on a poly-L-lysine sheet under semisolid overlays to study their phenotypic alterations and HIV-1 production by microscopy and electron microscopy. Another lymphoid cultures (MT-4, CEM, CEM-ss, AdCEM) similarly treated were infected with either HIV-1/RF or IIIB. Specificity of HIV-1 was compared to the effects of vesicular stomatitis virus (VSV). Unlike other cultures, HIV-1/RF infected C8166 cells in Eagle s MEM exhibited surface projections resembling hairy leukemia cells, which was followed by balloon degeneration and apoptosis. Immobilized HIV-1 infected cultures formed flat syncytia with several interdigitating dendritic projections. Syncytia shrunk with condensed nuclear material and axon-like filaments characteristic for infected macrophages. VSV induced enlargement and necrotic lysis of all cell types. Early postinfection with HIV-1, electron microscopy revealed irreversible membrane fusion above cell nuclei, and transient fusion between filaments. Transient presence of coated vesicles containing intact HIV-1 particles, Birbeck granule-like structures of Langerhans cells, fibrillar-lamellar structures resembling hairy leukemia or Sézary cells were detected. Late postinfection, high proportion of HIV-1 bud from polarized cytoplasm was empty particle, while that bud and entrapped in cytoplasmic vacuoles contained two or multiple cores in a fused envelope. The effect of early gene products of HIV-1 on HTLV-I and C8166 cells might elicit their latent potentials for monocyte or interdigitating dendritic cells, while in the later phase HTLV-I products might alter HIV-1 virion assembly.

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Seroepidemiology of the Human T-Cell Leukaemia/Lymphoma Viruses in Europe

Cited by 20 publications

References 36 publications

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

Prevalence of Human T-Lymphotropic Virus Type 1 in Brain-Dead Organ Donors

Human T-cell lymphotropic virus infection in pregnant women in Spain

Unique morphological alterations of the HTLV-I transformed C8166 cells by infection with HIV-1

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