Seroepidemiology of TORCH antibodies in the reproductive-aged women in China

Zhu, Shu; Li, Chao; Wu, Hong; Yue, Huakui; Zhang, Yuncong; Zhu, Baosheng; Ma, Jian; Feng, Zhenru; Kong, Hui; Cai, Xiaoyan; Ruan, Qiang

doi:10.1016/j.ejogrb.2020.09.010

Cited by 15 publications

(21 citation statements)

References 24 publications

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“…Chengdu city is the capital of Sichuan Province in southwest China and is the fourth most populous city in China, with GDP ranking seventh among Chinese cities in 2020. In a survey of eight hospitals in China, the seroprevalence of T. gondii IgG/IgM of pregnant women in Chengdu was approximately 4.4%/0.4%, which is higher than that reported from Kunming (west China) 2.7%/0.34%, Yantai and Shanghai (east China) 0.68%/0.20%, Xiameng and Shenzhen (south China) 0.90%/0.22%, and Shenyang and Beijing (north China) 0.83%/0.31% [ 24 ]. Hot pot and crayfish are popular foods in Chengdu, and eating undercooked crayfish or meat in hot pots may explain the increased risk of toxoplasmosis infection among Chengdu women.…”

Section: Discussionmentioning

confidence: 87%

One severe case of congenital toxoplasmosis in China with good response to azithromycin

et al. 2021

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Background Most infants infected with Toxoplasma gondii are completely asymptomatic at birth, yet they may develop ocular and neurological sequelae in the first few months of life. Cases of congenital toxoplasmosis with severe jaundice early after birth combined with pancytopenia and splenomegaly are extremely rare. Here, we report on a rare case of congenital toxoplasmosis presenting with severe jaundice and hemolysis early after birth combined with pancytopenia and splenomegaly. Case presentation A male preterm infant with severe jaundice and splenomegaly was admitted to our department. Laboratory examinations revealed severe hyperbilirubinemia, increased reticulocytes, and pancytopenia. After comprehensive analysis and examination, the final diagnosis was congenital toxoplasmosis, and the infant was treated with azithromycin and subsequently trimethoprim-sulfamethoxazole. Regular follow-up revealed congenital toxoplasmosis in both eyes, which was surgically treated, while neurofunctional assessment results were unremarkable. In this case of congenital toxoplasmosis combined with severe jaundice, we treated the infant with two courses of azithromycin, followed by trimethoprim-sulfamethoxazole after the jaundice resolved. Clinical follow-up indicated that this treatment was effective with few side effects; thus, this report may serve as a valuable clinical reference. Conclusions Timely diagnosis and adequate treatment are closely associated with congenital toxoplasmosis-related prognosis. Infants with congenital toxoplasmosis require long-term follow-up, focusing on nervous system development and ophthalmology.

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Section: Discussionmentioning

confidence: 87%

One severe case of congenital toxoplasmosis in China with good response to azithromycin

et al. 2021

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“…The weakness of our work may be the lack of full patient's follow-up, which will be pursued in the future and lack of definitive confirmation of positive cases by amniocentesis sampling. Due to various factors, the exact spread of TORCH infections is still unknown in most parts of the world [ 2 ]. In the present study, acute infections due to TOX, CMV, and RUV were 0.4%, 0.5%, and 0.6%, respectively.…”

Section: Discussionmentioning

confidence: 99%

“…They are considered to cause 2-3% of all birth defects in the fetus. Moreover, the letter “o” of TORCH as an abbreviation that refers to others can include some pathogen agents such as Arbovirus B19, Hepatitis B virus (HBV), Varicella-zoster virus, human immunodeficiency virus, and Zika virus [ 1 , 2 ]. The seroprevalence of these infections is different in various geographical areas [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

The Screening of Rubella Virus, Cytomegalovirus, Hepatitis B Virus, and Toxoplasma gondii Antibodies in Prepregnancy and Reproductive-Age Women in Tabriz, Iran

Nabizadeh

Ghotaslou

Salahi

et al. 2022

Infectious Diseases in Obstetrics and Gynecology

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Objectives. The organisms of Toxoplasma gondii, Rubella virus, Cytomegalovirus, and Herpes simplex virus as an acronym of TORCH are major pathogens in prepregnancy and reproductive-age women. These microorganisms are considered a serious problem and cause 2-3% of all birth defects in the fetus. Our study was aimed at screening the seroprevalence of TORCH antibodies among prepregnancy and reproductive-age women in Tabriz, Iran. Design and Setting. This study was carried out in 2726 prepregnancy and reproductive-age women, who were referred to the laboratory for prenatal TORCH screening. To detect the presence of IgG, IgM antibodies and Hepatitis B surface antigen against these microorganisms were carried out using a chemiluminescence immunoassay analyzer (CLIA). Results. In the current study, the rates of anti-Toxoplasma gondii IgG, anti-Rubella virus IgG, and anti-Cytomegalovirus IgG were found in 722 cases (26.5%), 2579 cases (94.6%0), and 2718 cases (99.7%), respectively. Moreover, the rates of anti-Toxoplasma gondii IgM, anti-Rubella virus IgM, and anti-Cytomegalovirus IgM were discovered in 10 cases (0.4%), 13 cases (0.5%), and 16 cases (0.6%), respectively. The Hepatitis B surface antigen was found in 32 cases (1.2%). The dissemination of positive TORCH in various ages was different ( P < 0.05 ). Conclusions. In our study, the seroprevalence of acute TORCH infections was relatively low. Due to the probability of vertical transmission to the fetus during pregnancy and the unpleasant complication of these pathogens, it is essential to be screened for detection of specific IgG and IgM antibodies in reproductive ages.

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“…TORCH syndrome symptoms range from asymptomatic ndings to chorioretinitis [17], hearing impairment, hydrocephalus, and fetal psychomotor disorders [18]. Toxoplasma infection is prevalent in China due to its special diet [19]. Because of the adverse effects of this infection on the fetus, it is critical to diagnose infected women before pregnancy to prevent fetal disorders.…”

Section: Introductionmentioning

confidence: 99%

“…But Southeast Asia and sub-Saharan Africa have the highest mortality rates from this infections [23]. A general national study that involves TORCH effects on pregnant women and whether they are associated with adverse pregnancy outcomes is not available [19]. Since our country is also in a high-risk region, research in this eld seems necessary.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Toxoplasma gondii, Rubella and Cytomegalovirus Among Women of Reproductive Age in Mashhad, Northeast of Iran

Nasimi

Fani

Salehi

et al. 2021

Preprint

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Purpose: TORCH syndrome is responsible for 2-3% of all congenital anomalies caused by Toxoplasma gondii (T. gondii), Rubella virus (RV), Cytomegalovirus (CMV), and Herpes simplex virus (HSV). The current study aimed to determine the prevalence of TORCH infection in women in Mashhad. Method: This cross-sectional study was conducted on 417 patients who were referred to three laboratories in Mashhad, Iran. Laboratory data were collected from April 2016 to March 2020 to detect the specific IgG and IgM against TORCH syndrome.Result: The specific IgG antibodies were found to be positive in for CMV in 402 cases (96.4%), for RV in 394 cases (94.5%), and for T. gondii in 80 cases (19.2%). Moreover, 7 (1.6%) of them were found to be positive for anti-CMV IgM, 6 (1.4%) for anti-IgM RV, and 8 (1.9%) for anti-IgM T. gondii. In addition, the relationship between age and anti- T. gondii IgG in the age group of 37-47 years was 6.44 times higher than the age group of 17-27 years. Also, The relationship between age and anti-CMV IgG in the age group of 27-37 years was 4.13 times higher than the age group of 37-47 years.Conclusion: All women of reproductive age should be screened for the TORCH complex regularly to prevent congenital TORCH syndrome.

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Seroepidemiology of TORCH antibodies in the reproductive-aged women in China

Cited by 15 publications

References 24 publications

One severe case of congenital toxoplasmosis in China with good response to azithromycin

One severe case of congenital toxoplasmosis in China with good response to azithromycin

The Screening of Rubella Virus, Cytomegalovirus, Hepatitis B Virus, and Toxoplasma gondii Antibodies in Prepregnancy and Reproductive-Age Women in Tabriz, Iran

Seroprevalence of Toxoplasma gondii, Rubella and Cytomegalovirus Among Women of Reproductive Age in Mashhad, Northeast of Iran

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