Seroepidemiology of Varicella-Zoster Virus in Korea

Lee, Hyunju; Cho, Hye‐Kyung; Kim, Kyung Hyo

doi:10.3346/jkms.2013.28.2.195

Cited by 29 publications

(24 citation statements)

References 14 publications

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“…A cross-sectional study in four Korean hospitals tested the seroprevalence of 887 patients in which overall 87.6% had anti-VZV IgG antibody [25]. [26]. The decreasing trend of antibody level may explain the continuing increase of varicella in all given cohorts despite the introduction of the vaccine into the national immunisation programme.…”

Section: Epidemiology and Infectionmentioning

confidence: 99%

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

et al. 2019

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In the Republic of Korea, despite the introduction of one-dose universal varicella vaccination in 2005 and achieving a high coverage rate of 98.9% in 2012, the incidence rate has been increased sevenfold. This study aimed to investigate time trends of varicella incidence rate, assessing the age, period and birth cohort effects. We used national data on the annual number of reported cases from 2006 to 2017. A log-linear Poisson regression model was used to estimate age–period–cohort effects on varicella incidence rate. From 2006 to 2017, the incidence of varicella increased from 22.5 cases to more than 154.8 cases per 100 000. Peak incidence has shifted from 4 to 6 years old. The estimated period and cohort effects showed significant upward patterns, with a linear increasing trend by net drift. There has been an increase in the incidence among the Korean population regarding period and cohort despite the universal vaccination of varicella vaccine. Our data suggest the need for additional studies to address the current gap in herd immunity.

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Section: Epidemiology and Infectionmentioning

confidence: 99%

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

et al. 2019

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“…The seroprevalences determined by ELISA showed a similar trend by age group. A previous study, using the same commercial ELISA kit used in the present study, was performed in 2009 in Korea; that study reported a VZV seroprevalence of ~94% in teenage subjects and 98% in subjects aged ⩾20 years [ 22 ]. In the present study, the seroprevalences determined by ELISA were lower than they were in a previous report, 83·3% in teenage subjects and 93·0% in subjects in their twenties and thirties.…”

Section: Discussionmentioning

confidence: 99%

“…For early detection of such epidemiological and seroepidemiological changes, and in order to establish appropriate strategies for controlling breakthrough VZV infections, repeated surveillance of immune status against VZV in the community is necessary. However, only studies including limited numbers of subjects have been performed in Korea [ 20 – 22 ]. In addition, only one seroepidemiological study for VZV using the fluorescent antibody to membrane antigen (FAMA) test has been performed; this study was limited to adults aged >40 years [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test

et al. 2014

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SUMMARYWe conducted a cross-sectional seroepidemiological study in 2012–2013 to determine the seroprevalence of varicella-zoster virus (VZV) in adolescents and adults living in Korea, where varicella vaccination has been recommended universally at age 12–15 months since 2005. Residual serum samples were collected from 1196 healthy adults and adolescents aged ⩾10 years between November 2012 and March 2013. The fluorescent antibody to membrane antigen (FAMA) test and enzyme-linked immunosorbent assay (ELISA) were performed to determine the seroprevalence of VZV. The seroprevalences of VZV were compared between six age groups: 10–19, 20–29, 30–39, 40–49, 50–59, and ⩾60 years. The seroprevalence of VZV in the entire study cohort was 99·1% according to the FAMA test and 93·1% as determined by ELISA. The seroprevalences of the six age groups were as follows: 96·0%, 99·5%, 99·5%, 99·5%, 100%, and 100%, respectively, by the FAMA test, and 83·3%, 93·0%, 93·0%, 97·5%, 94·5%, and 97·5%, respectively, by ELISA. Seroprevalence increased significantly with age (P < 0·001); moreover, the seroprevalence in subjects aged 10–19 years was significantly lower than in other age groups (P < 0·001), as measured by both the FAMA test and ELISA. Thus, strategies to increase protective immunity against VZV in teenagers are necessary.

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“…In Croatia, the prevalence of VZV-antibody among women of child-bearing age reported equal 84.3% (18). In Italy (19), Tunisia (20) and Korea (21), it has been reported 80.9%, 80.9% and 89.6%, respectively. In 2007, 96.1% of Spanish women during their fertility period were immune to VZV (22).…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Antibodies against Varicella Zoster Virus among Women before Marriage in Yazd, Iran

et al. 2016

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Background and Aims: Varicella-zoster virus (VZV) infection among pregnant women can cause a serious threat to the health of mother and fetus. Varicella is clearly less dangerous for immunized mothers. The aim of this study was to determine the prevalence of VZV antibody among women before marriage. Materials and Methods: This cross-sectional study was conducted on 300 women of childbearing age who referred to Yazd clinic for premarital screening. The enzyme-linked immunosorbent assay (ELISA) technique was performed to detect antibodies against VZV. Demographic characteristics of each participant, including age, educational level, place of residence, family and self-reported history of chickenpox were collected by a questionnaire. Results: Mean age of women under study was 23±5.4 years that 223 participants (73.7%) were seropositive, and 77 cases (25.7%) were seronegative for anti-VZV antibody, while 2 (0.6%) subjects had an equivocal result. A higher immunity ratio (86.4%) was found among older women (33-44 years). Data showed no significant correlation between immunity to VZV and age, educational level, place of residence. A statistically significant association was found between the family history, self-reported history of chickenpox and immunity to VZV. The positive and negative predictive values for self-reported history of chicken pox were 97.1% and 81.1%, respectively. Conclusions: A significant number of women before marriage had no immunity to VZV. They are in risk of getting varicella, which can cause serious complications in mother and fetus. It, therefore, seems necessary to screen women of child-bearing age for anti-VZV antibody. In addition, vaccination against VZV in Iranian women before marriage can be a good recommendation.

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Seroepidemiology of Varicella-Zoster Virus in Korea

Cited by 29 publications

References 14 publications

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

Increasing varicella incidence rates among children in the Republic of Korea: an age–period–cohort analysis

Seroepidemiology of varicella-zoster virus in Korean adolescents and adults using fluorescent antibody to membrane antigen test

Seroprevalence of Antibodies against Varicella Zoster Virus among Women before Marriage in Yazd, Iran

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