Serogroup B, Electrophoretic Type 15<i>Neisseria meningitidis</i>in Canada

Kertesz, Daniel A.; Coulthart, Michael B.; Ryan, J. A.; Johnson, Wendy M.; Ashton, F. E.

doi:10.1086/517439

Cited by 59 publications

(33 citation statements)

References 10 publications

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“…The global spread of this ET-15 clone leading to outbreaks in multiple countries has been described (33). Although sporadic cases of ET-15 MenB have been observed in Canada (probably through capsule switching), such strains failed to establish sufficiently to cause any sustained disease in Canada (34). MenY ST-11 has not been observed in Canada (authors' unpublished observation).…”

Section: Discussionmentioning

confidence: 99%

Invasive serogroup W Neisseria meningitidis (MenW) in Ontario, Canada shows potential clonal replacement during the period January 1, 2009 – June 30, 2016

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Invasive serogroup W Neisseria meningitidis (MenW) in Ontario, Canada shows potential clonal replacement during the period January 1, 2009 – June 30, 2016

et al. 2016

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“…Evidence of horizontal transfer of siaD genes encoding polysialyltransferases has been shown to result in capsular sero- group switching in vitro and in vivo (2,9,13,34). Capsular switching may occur naturally, and immunization with vaccines that target serogroup capsules could potentially favor the emergence of serogroup B ST-11 complex strains as reported in Canada and Spain, where serogroup B ST-11 complex strains have emerged since the introduction of serogroup C conjugate vaccines (1,24,33).…”

Section: Discussionmentioning

confidence: 99%

Clonal Distribution of Invasive Neisseria meningitidis Serogroup C Strains Circulating from 1976 to 2005 in Greater São Paulo, Brazil

et al. 2007

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Meningococcal disease is characterized by cyclic fluctuations in incidence, serogroup distribution, and antigenic profiles. In greater São Paulo, Brazil, there has been a constant increase in the incidence of serogroup C meningococcal disease since the late 1980s. To gain an understanding of changes in serogroup C meningococcal disease over three decades in greater São Paulo, Brazil, 1,059 invasive Neisseria meningitidis serogroup C isolates from 1976 and 2005 were analyzed. Three major clone complexes, sequence type (ST)-11, ST-8, and ST-103, were identified by multilocus sequence typing, and the isolates were characterized by serotyping and 16S rRNA typing. During the 30-year period, there were two major antigenic replacements: from 2a:P1.(5,2) to 2b:P1.3 and subsequently to 23:P1.14-6. All strains of clone ST-103 were characterized as serotype 23 and serosubtype P1.14-6. The origin of 23:P1.14-6 ST-103 complex strains is unknown, but efforts are needed to monitor its spread and define its virulence. The antigenic replacements we observed likely represent a mechanism to sustain meningococcal disease in the population as immunity to circulating strains accumulated.

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“…Capsule switching has already been reported in Canada and in Spain after mass vaccination campaigns (2,8,14) and in the Czech Republic during an epidemic situation (9). Since in Italy the incidence of invasive meningococcal disease is low and no mass vaccination has been introduced, the presence of capsuleswitched strains may be more easily attributable to a selection for competition between meningococcal genotypes in the nasopharynx than to vaccine-induced protective immunity.…”

mentioning

confidence: 99%

“…In Neisseria meningitidis, the horizontal transfer of siaD genes encoding polysialyltransferases has been shown to result in capsular serogroup switching in vitro and in vivo (2,4,8,15). Capsule switching may be an important virulence mechanism of meningococci and other encapsulated bacterial pathogens (7,15), with significant implications for the use of specific polysaccharide vaccines.…”

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confidence: 99%

First Report of Capsule Replacement among Electrophoretic Type 37 Neisseria meningitidis Strains in Italy

et al. 2003

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This report describes the C-to-B capsular switching in four Neisseria meningitidis strains belonging to the electrophoretic type 37 (ET-37) complex. In particular, one strain belonged to the new sequence type 1860, which was first detected in the year 2000 in Italy and is now frequently isolated. The presence of switched serogroup B strains deserves special attention if they prove as able to spread as their serogroup C progenitors belonging to the hypervirulent ET-37 complex.

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Serogroup B, Electrophoretic Type 15Neisseria meningitidisin Canada

Cited by 59 publications

References 10 publications

Invasive serogroup W Neisseria meningitidis (MenW) in Ontario, Canada shows potential clonal replacement during the period January 1, 2009 – June 30, 2016

Invasive serogroup W Neisseria meningitidis (MenW) in Ontario, Canada shows potential clonal replacement during the period January 1, 2009 – June 30, 2016

Clonal Distribution of Invasive Neisseria meningitidis Serogroup C Strains Circulating from 1976 to 2005 in Greater São Paulo, Brazil

First Report of Capsule Replacement among Electrophoretic Type 37 Neisseria meningitidis Strains in Italy

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