Serologic Evidence of Campylobacter jejuni/coli Enteritis in Patients with Guillain-Barre Syndrome

Gruenewald, Ruben; Ropper, Allan H.; Lior, H.; Chan, Joseph; Lee, Richard; Molinaro, Vernaleah S.

doi:10.1001/archneur.1991.00530220102027

Cited by 49 publications

(21 citation statements)

References 21 publications

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“…Our data showed that the great majority (80.6%) of the GBS patients had serological evidence of a previous C. jejuni infection, compared to 3.5% of the healthy controls. These findings exceeded by far the results obtained with a commercially available Campylobacter-specific CFA, which was used as the reference method, as well as previously reported data (2,6,8,10,14,18,19,21,23,25,29,31). Confirmatory data from fecal sample cultures for C. jejuni isolation were not available.…”

Section: Vol 13 2006 Role Of C Jejuni In Triggering Guillain-barrécontrasting

confidence: 67%

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Improved Serological Diagnosis Stresses the Major Role of Campylobacter jejuni in Triggering Guillain-Barré Syndrome

Schmidt-Ott

Schmidt

Feldmann

et al. 2006

Clin Vaccine Immunol

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Guillain-Barré syndrome (GBS) is a postinfectious autoimmune polyradiculoneuropathy. The most frequent antecedent pathogen is Campylobacter jejuni, followed by cytomegalovirus. However, more than 40% of GBS cases currently cannot be attributed to triggering events. This might be due to the shortcomings of the serological assays used for diagnosing infections, in particular for C. jejuni. In our study investigating 36 patients with acute GBS, standard serological methods identified the triggering viral or bacterial etiology in only 25% of cases. However, using a highly specific enzyme-linked immunosorbent assay based on two recombinant outer antigens encoded by C. jejuni genes Cj0017 (P39) and Cj0113 (P18), we found serological evidence of a preceding C. jejuni infection in 80.6% of the patients but in only 3.5% of the controls. We conclude that the role of C. jejuni in triggering GBS has been greatly underestimated.

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Section: Vol 13 2006 Role Of C Jejuni In Triggering Guillain-barrécontrasting

confidence: 67%

“…Most of the data supporting the association of antecedent infections with GBS result from serological studies (2,6,8,10,14,18,19,21,23,25,29,31). Routinely used serological assays for the diagnosis of CMV and EBV infections are of high quality, with sensitivities and specificities of Ͼ90%.…”

Section: Vol 13 2006 Role Of C Jejuni In Triggering Guillain-barrémentioning

confidence: 99%

Improved Serological Diagnosis Stresses the Major Role of Campylobacter jejuni in Triggering Guillain-Barré Syndrome

Schmidt-Ott

Schmidt

Feldmann

et al. 2006

Clin Vaccine Immunol

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“…11 In addition, neurologic symptoms have been reported to be more severe and more likely to be reversible when Guillain-Barre syndrome is preceded by C jejuni infection. 12 The combination of recent C jejuni infection and positive antigangliocyte GMI heralds a poor prognosis. 13 The risk of developing Guillain-Barre syndrome after infection with Campylobacter is actually quite low.…”

Section: Discussionmentioning

confidence: 99%

Severe Guillain-Barre Syndrome Associated With Campylobacter jejuni Infection With Failure to Respond to Plasmapheresis and Immunoglobulin

Allen

Antony

1999

The Journal of the American Board of Family Medicine

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“…They have been witnessed in up to 60% o f these patients in some studies, probably signifying the regional distribution o f this bacteria. [20,65,110,111], Attempts to identify a "pathogenic' serotype have largely been unrevealing. Vacci nations have sporadically been incriminated as possible triggers of GBS [112].…”

Section: Infectious Etiologiesmentioning

confidence: 99%

Guillain-Barré as an Autoimmune Disease

Shoenfeld

George²,

Peter³

1996

Int Arch Allergy Immunol

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Guillain-Barré syndrome (GBS) entails a demyelinating process of the peripheral nervous system. The etiopathogenesis of the syndrome is still a matter of debate although considerable progress has been accomplished in the recent years. Abundant evidence has been put forward so as to support the role of the immune system in initiating and perpetuating the ongoing damage culminating in the emergence of the clinically overt syndrome. As such, data on the involvement of the humoral immune pathways add to the information already presented with regard to cell-mediated mechanisms participating in disruption of peripheral nerve. The following review will focus on the current knowledge of these complex mechanisms and the relative significance of each in the pathogenesis of GBS.

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Serologic Evidence of Campylobacter jejuni/coli Enteritis in Patients with Guillain-Barre Syndrome

Cited by 49 publications

References 21 publications

Improved Serological Diagnosis Stresses the Major Role of Campylobacter jejuni in Triggering Guillain-Barré Syndrome

Improved Serological Diagnosis Stresses the Major Role of Campylobacter jejuni in Triggering Guillain-Barré Syndrome

Severe Guillain-Barre Syndrome Associated With Campylobacter jejuni Infection With Failure to Respond to Plasmapheresis and Immunoglobulin

Guillain-Barré as an Autoimmune Disease

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