Serologic evidence of the circulation of the hepatitis E virus and the prevalence of antibodies against hepatitis A in an indigenous population in northern Argentina

Remondegui, Carlos; Ceballos, Susana; Arce, Lorena Paola; Pintado, Eduardo; Vidaurre, Rene; Nitschko, Hans; Osterman, Andreas; Pinto, María Guadalupe Vizoso

doi:10.1016/j.ram.2020.10.006

Cited by 8 publications

(8 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The observed seroprevalences ranged from 0% to 10% (median 1%). Values above 5% were reported for pediatric patients in Mexico [ 36 ] (6.1%, n = 99), ethnic groups in Argentina [ 37 ] (8.7%, n = 126), and female blood donors in Brazil [ 38 ] (10%, n = 20). A pooled seroprevalence was 0.9% (95% CI: 0.6%–1.5%, I 2 = 83%, tau 2 = 0.97).…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

Background Hepatitis E virus (HEV) infection is responsible for inflammatory liver disease and can cause severe health problems. Because the seroprevalence of HEV varies within different population groups and between regions of the continent, we conducted a systematic review on the topic in order to provide evidence for targeted prevention strategies. Methods We performed a systematic review in PubMed, SCIELO, LILACS, EBSCO, and Cochrane Library and included reports up to 25 May 2021 (PROSPERO registration number: CRD42020173934). We assessed the risk of bias, publication bias, and heterogeneity between studies and conducted a random-effect meta-analysis for proportions using a (binomial-normal) generalized linear mixed model (GLMM) fitted by Maximum Likelihood (ML). We also reported other characteristics like genotype and risk factors. Results Of 1212 identified records, 142 fulfilled the inclusion criteria and were included in the qualitative analysis and 132 in the quantitative analysis. Our random-effects GLMM pooled overall estimate for past infection (IgG) was 7.7% (95% CI 6.4%–9.2%) with high heterogeneity (I2 = 97%). We found higher seroprevalence in certain population groups, for example in people with pig related exposure for IgG (ranges from 6.2%–28% and pooled estimate of 13.8%, 95% CI: 7.6%–23.6%), or with diagnosed or suspected acute viral hepatitis for IgM (ranges from 0.3%–23.9% and pooled estimate of 5.5%, 95% CI: 2.0%–14.1%). Increasing age, contact with pigs and meat products, and low socioeconomic conditions are the main risk factors for HEV infection. Genotype 1 and 3 were documented across the region. Conclusion HEV seroprevalence estimates demonstrated high variability within the Americas. There are population groups with higher seroprevalence and reported risk factors for HEV infection that need to be prioritized for further research. Due to human transmission and zoonotic infections in the region, preventive strategies should include water sanitation, occupational health, and food safety.

show abstract

Section: Resultsmentioning

confidence: 99%

Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis

et al. 2022

View full text Add to dashboard Cite

show abstract

“… Distribution of hepatitis E virus in Latin America. The most prevalent host studies in the region are human and swine, but dolphins and deer have also been reported, together with sewage [ 90 , 91 , 92 ]. …”

Section: Figurementioning

confidence: 99%

Tracing the History of Hepatitis E Virus Infection in Mexico: From the Enigmatic Genotype 2 to the Current Disease Situation

Viera-Segura,

Calderón-Flores,

Batún-Alfaro

et al. 2023

Viruses

View full text Add to dashboard Cite

Hepatitis E virus (HEV) is the major cause of acute viral hepatitis worldwide. This virus is responsible for waterborne outbreaks in low-income countries and zoonosis transmission in industrialized regions. Initially, considered self-limiting, HEV may also lead to chronic disease, and evidence supports that infection can be considered a systemic disease. In the late 1980s, Mexico became a hot spot in the study of HEV due to one of the first virus outbreaks in Latin America related to enterically transmitted viral non-A, non-B hepatitis. Viral stool particles recovered from Mexican viral hepatitis outbreaks represented the first identification of HEV genotype (Gt) 2 (Gt2) in the world. No new findings of HEV-Gt2 have been reported in the country, whereas this genotype has been found in countries on the African continent. Recent investigations in Mexico have identified other strains (HEV-Gt1 and -Gt3) and a high frequency of anti-HEV antibodies in animal and human populations. Herein, the potential reasons for the disappearance of HEV-Gt2 in Mexico and the advances in the study of HEV in the country are discussed along with challenges in studying this neglected pathogen. These pieces of information are expected to contribute to disease control in the entire Latin American region.

show abstract

“…Recently, Villar et al (2020) reported a remarkably low anti-HEV prevalence (0.2%) in the Apinajé indigenous population of the western Brazilian Amazon [ 31 ]. Other studies have reported anti-HEV seroprevalence rates of 5.6% in indigenous communities in Argentina [ 32 ] and 1.9% in Suriname [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of the Hepatitis E Virus in Indigenous and Non-Indigenous Communities from the Brazilian Amazon Basin

Vasconcelos,

de Oliveira,

Sánchez-Arcila

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Hepatitis E virus (HEV) infection is a common cause of acute viral hepatitis in tropical regions. In Brazil, HEV G3 is the only genotype detected to date. Reports on HEV prevalence are heterogeneous. We aimed to compare the prevalence of anti-HEV among three populations living in the Brazilian Amazon basin. Two cross-sectional studies were conducted in urban, rural, and Yanomami indigenous areas. Plasma samples from 428 indigenous and 383 non-indigenous subjects were tested for anti-HEV IgG using enzyme-linked immunosorbent assays. The overall prevalence of anti-HEV was 6.8% (95%CI: 5.25–8.72), with 2.8% (12/428) found in the Yanomami areas, 3% (3/101) in an urban area, and 14.2% (40/282) in a rural area. Multivariate logistic analysis indicated that patients aged 31–45 years or ≥46 years are more likely to present anti-HEV positivity, with a respective aOR of 2.76 (95%CI: 1.09–7.5) and 4.27 (95%CI: 1.58–12.35). Furthermore, residence in a rural area (aOR: 7.67; 95%CI: 2.50–33.67) represents a relevant risk factor for HEV infection. Additional studies detecting HEV RNA in fecal samples from both humans and potential animal reservoirs are necessary to comprehensively identify risk factors associated with HEV exposure.

show abstract

Serologic evidence of the circulation of the hepatitis E virus and the prevalence of antibodies against hepatitis A in an indigenous population in northern Argentina

Cited by 8 publications

References 48 publications

Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis

Seroprevalence of hepatitis E virus infection in the Americas: Estimates from a systematic review and meta-analysis

Tracing the History of Hepatitis E Virus Infection in Mexico: From the Enigmatic Genotype 2 to the Current Disease Situation

Seroprevalence of the Hepatitis E Virus in Indigenous and Non-Indigenous Communities from the Brazilian Amazon Basin

Contact Info

Product

Resources

About