2019
DOI: 10.1016/j.ttbdis.2019.07.002
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Serologic survey of the Crimean-Congo haemorrhagic fever virus infection among wild rodents in Hungary

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Cited by 12 publications
(18 citation statements)
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“…We identified four new bank vole virus genomes from three families, increasing the known diversity of viruses in bank voles to nearly 20 species [1,[6][7][8][9][10][11][12][13][14][15][16]. The new virus genomes were not endemic to Ukraine, but were present also in Swedish bank voles, raising the possibility that these viruses are present in bank voles throughout much of their geographic range.…”
Section: Discussionmentioning
confidence: 95%
See 1 more Smart Citation
“…We identified four new bank vole virus genomes from three families, increasing the known diversity of viruses in bank voles to nearly 20 species [1,[6][7][8][9][10][11][12][13][14][15][16]. The new virus genomes were not endemic to Ukraine, but were present also in Swedish bank voles, raising the possibility that these viruses are present in bank voles throughout much of their geographic range.…”
Section: Discussionmentioning
confidence: 95%
“…The bank vole (Myodes glareolus), a small rodent that is common in woodland habitats throughout much of Europe and northwest Asia, is an zoonotic hyper-reservoir [3]. Bank voles host disease-causing viruses such as Puumala hantavirus [4], flavivirus tick borne encephalitis virus [5], orthonairovirus Crimean-Congo hemorrhagic fever virus [6], cowpox virus [7], and picornavirus Ljungan virus [8]; moreover, bank voles harbor paramyxoviruses [9,10], alphacoronaviruses [11], polyomaviruses [12], herpesviruses [13,14], anelloviruses [15], and hepaciviruses [16]. As bank voles host a diverse and important viral community, this species is an ideal model in which to study the potential effects of environmental factors on virus community and population dynamics.…”
Section: Introductionmentioning
confidence: 99%
“…To our knowledge, this is the first study that used designed siRNAs against CCHFV replication in vitro and the first study to provide RNAi solution to all three genomic segments of a nairovirus in parallel. Currently, CCHFV constitutes a notable public health concern in our region, with significant geographic expansion in recent decades and growing epidemic potential [26][27][28]. One major limitation of our study is the lack of combinative experiments; however, it projects future research directions well.…”
Section: Discussionmentioning
confidence: 96%
“…Viral adsorption was allowed for 1 h at 37 • C. After washing cells with PBS three times, cells were incubated for 3 days at 37 • C in DMEM supplemented with 2% FBS. The fixation and the immunofluorescence assay were performed as previously described using with polyclonal mouse antibody, which was produced against the recombinant CCHFV capsid protein [27]. The percentage of infected cells was observed with immunofluorescence microscopy and recorded for each virus dilution, then results were used to mathematically calculate a TCID50 result with the Spearman-Karber method.…”
Section: Cell Line Virus Amplification and Titer Determinationmentioning
confidence: 99%
“…Small interfering RNAs (siRNA) are the active agents in RNA interference. The siRNAs are [21][22] nucleotides long, serve as a guide for cognate mRNA degradation [17]. Naturally, these siRNAs are a result of endonucleolytic processing of a larger precursor RNA.…”
Section: Introductionmentioning
confidence: 99%