Serologic Tests for Syphilis and the False-Positive Reactor

Wuepper, Kirk D.

doi:10.1001/archderm.1966.01600260044004

Cited by 12 publications

(6 citation statements)

References 20 publications

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“…In contrast, one-half of the group were reactive in all four reagin tests. (Wuepper, Bodily, and Tuffanelli, 1966). That this degree of sensitivity and specificity is the case among drug addicts has been shown in studies comparing both the FTA test (Harris and others, 1962) and the FTA-ABS test (Tuffanelli, 1968) with the TPI test.…”

Section: Methodsmentioning

confidence: 84%

“…In our initial survey of 1,646 addicts, the VDRL and FTA-ABS tests were employed since they are the most commonly used reagin and treponemal tests. In addition, the FTA-ABS test has been shown to be more sensitive and nearly as specific as what some consider the nonpareil of syphilis serology, the Treponema pallidum immobilization (TPI) test (Wuepper, Bodily, and Tuffanelli, 1966). That this degree of sensitivity and specificity is the case among drug addicts has been shown in studies comparing both the FTA test (Harris and others, 1962) and the FTA-ABS test (Tuffanelli, 1968) with the TPI test.…”

Section: Commentmentioning

confidence: 97%

See 1 more Smart Citation

Biological false positive serological tests for syphilis among drug addicts.

Kaufman¹,

Weiss²,

Moore³

et al. 1974

Sexually Transmitted Infections

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Section: Methodsmentioning

confidence: 84%

Section: Commentmentioning

confidence: 97%

Biological false positive serological tests for syphilis among drug addicts.

Kaufman¹,

Weiss²,

Moore³

et al. 1974

Sexually Transmitted Infections

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“…None of 500 cases of chronic BFP reaction in the literature had polymyositis (Berglund and Carlsson, 1966;Wuepper, Bodily, and Tuffanelli, 1966;Putkonen, Jokinen, Lassus, and Mustakallio, 1967;Catterall, 1972;Harvey and Shulman, 1974). However, it is conceivable that some of these reactors whose basic disease was SLE, Sjogren's syndrome, or 'possible connective-tissue dieasse', could have had myositis as part of their primary autoimmune disease.…”

Section: Discussionmentioning

confidence: 99%

Polymyositis with biological false-positive serological test for syphilis. A case report.

Frayha¹

1976

Sexually Transmitted Infections

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“…just reflect frequent screening of pregnant women) (6)(7)(8)(9)(10). Medical conditions such as autoimmune disorders, including systemic lupus erythematosus (SLE), cancers, malaria, other treponemal infections, human immunodeficiency virus (HIV) infection, and hepatitis C infections, have been associated with increases in BFPs (6,7,(9)(10)(11)(12)(13).…”

mentioning

confidence: 99%

Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017

et al. 2019

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Discordant syphilis test results, with a reactive nontreponemal test and nonreactive treponemal test are usually considered biological false-positive test results (BFPs), which can be attributed to other conditions. Syphilis surveillance laws mandate laboratory reporting of reactive syphilis tests, which include many BFPs. We describe the frequency of BFPs, titer distributions, and titer increases from reported test results in Florida and New York City (NYC). Reactive nontreponemal tests for individuals with at least one nonreactive treponemal test and no reactive treponemal test were extracted from sexually transmitted disease (STD) surveillance systems in Florida and NYC from 2013 to 2017. Characteristics of individuals with BFPs were analyzed after selecting the observation with the highest titer from each individual. We next considered all results from individuals to characterize persons who had a 4-fold titer increase between successive nontreponemal tests. Among 526,540 reactive nontreponemal tests, there were 57,580 BFPs (11%) from 39,920 individuals. Over 90% (n = 52,330) of BFPs were low titer (≤1:4), but 654 (1%) were high-titer BFPs (≥1:32). Very high-titer (≥1:128) BFPs were more common among individuals over 60 years of age (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.22 to 5.91). A 4-fold increase in titer was observed among 1,863 (14%) individuals with more than one reported BFP. Most BFPs detected by surveillance were low titer, but some were high titer and some had a 4-fold increase in titer. Review of patient histories might identify underlying conditions contributing to these high and rising titers.

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Serologic Tests for Syphilis and the False-Positive Reactor

Cited by 12 publications

References 20 publications

Biological false positive serological tests for syphilis among drug addicts.

Biological false positive serological tests for syphilis among drug addicts.

Polymyositis with biological false-positive serological test for syphilis. A case report.

Frequency and Characteristics of Biological False-Positive Test Results for Syphilis Reported in Florida and New York City, USA, 2013 to 2017

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